KAST-BAR: Knowledge-Anchored Semantically-Dynamic Topology Brain Autoregressive Modeling for Universal Neural Interpretation

摘要

While EEG foundation models have shown significant potential in universal neural decoding across tasks, their advancement remains constrained by the inadequacy modeling of *complex spatiotemporal topology*, as well as the inherent *modality gap* between low-level physiological signals and high-level textual semantics. To address these challenges, we propose a **K**nowledge-**A**nchored **S**emantically-Dynamic **T**opology **B**rain **A**uto**r**egressive Model (KAST-BAR), which dynamically aligns physiological representations derived from multi-level brain topology with an expert-level semantic space. Specifically, we design a Dual-Stream Hierarchical Attention (DSHA) encoder that accurately captures the brain's intrinsic non-Euclidean topology by modeling local temporal dynamics with global spatial contexts. On this basis, a Knowledge-Anchored Semantic Profiler (KASP) is proposed to synthesize physically-grounded and instance-level textual profiles, which subsequently drive a Semantic Text-Aware Refiner (STAR) to dynamically reconstruct EEG representations using Latent Expert Queries. By conducting large-scale pre-training on 21 diverse datasets to build a foundation model, KAST-BAR effectively integrates expert-level medical knowledge into EEG signal representations, consistently achieving state-of-the-art performance across six downstream tasks. Our code is available at https://anonymous.4open.science/r/KAST-BAR