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Wenzhe He, Xiaojun Chen, Wentang Chen, Hongyu Wang, Ying Liu 0027, Ruihui Li

Semantic Scene Completion (SSC) aims to generate a complete semantic scene from an incomplete input. Existing approaches often employ dense network architectures with a high parameter count, leading to increased model complexity and resource demands. To address these limitations, we propose RWKV-PCSSC, a lightweight point cloud semantic scene completion network inspired by the Receptance Weighted Key Value (RWKV) mechanism. Specifically, we introduce a RWKV Seed Generator (RWKV-SG) module that can aggregate features from a partial point cloud to produce a coarse point cloud with coarse features. Subsequently, the point-wise feature of the point cloud is progressively restored through multiple stages of the RWKV Point Deconvolution (RWKV-PD) modules. By leveraging a compact and efficient design, our method achieves a lightweight model representation. Experimental results demonstrate that RWKV-PCSSC reduces the parameter count by 4.18× and improves memory efficiency by 1.37× compared to state-of-the-art methods PointSSC[51]. Furthermore, our network achieves state-of-the-art performance on established indoor (SSC-PC, NYUCAD-PC) and outdoor (PointSSC) scene dataset, as well as on our proposed datasets (NYUCAD-PC-V2, 3D-FRONT-PC).

Tianyi Ma, Maoying Qiao

In test-time adaptation, handling constant domain change using a single sample at a time presents two key challenges: efficiently stabilizing adaptation and effectively preventing catastrophic forgetting. This paper introduces a single-sample continual test-time adaptation (S-CoTTA) task to address these challenges. Existing works mainly either 1) apply continual test-time adaptation methods with an inefficient moving window that increases memory overhead or 2) filter out high-uncertainty samples to maintain stability. The former handled forgetting but failed to stabilize adaptation efficiently, while the latter neglected the catastrophic forgetting issues. We argue that both efficient tuning stabilization and forgetting prevention should be addressed simultaneously. To this end, we proposed a novel Efficient Buffer and Resetting (EBaR) method for S-CoTTA. EBaR employs a novel memory-efficient buffer to store samples based on their uncertainty levels and utilizes them to update the model with different losses to enhance stability. EBaR also incorporates a novel elastic resetting unit to dynamically reset the parameters based on their sensitivity to domain shift. The elastic resetting strategy effectively mitigates catastrophic forgetting while retaining useful target domain knowledge. Comprehensive experimental evaluations demonstrate the effectiveness and efficiency of both components. Combining their benefits, EBaR surpasses state-of-the-art methods across multiple datasets, including CIFAR10-C, CIFAR100-C, ImageNet-C, and CCC, for the S-CoTTA task.

Shaohua Liu 0003, Ning Gao 0004, Zuoya Gu, Hongkun Dou, Yue Deng 0001, Hongjue Li

Reconstructing realistic underwater scenes from underwater video remains a meaningful yet challenging task in the multimedia domain. The inherent spatiotemporal degradations in underwater imaging, including caustics, flickering, attenuation, and backscattering, frequently result in inaccurate geometry and appearance in existing 3D reconstruction methods. While a few recent works have explored underwater degradation-aware reconstruction, they often address either spatial or temporal degradation alone, falling short in more real-world underwater scenarios where both types of degradation occur. We propose MartineSTD-GS, a novel 3D Gaussian Splatting-based framework that explicitly models both temporal and spatial degradations for realistic underwater scene reconstruction. Specifically, we introduce two paired Gaussian primitives: Intrinsic Gaussians represent the true scene, while Degraded Gaussians render the degraded observations. The color of each Degraded Gaussian is physically derived from its paired Intrinsic Gaussian via a Spatiotemporal Degradation Modeling (SDM) module, enabling self-supervised disentanglement of realistic appearance from degraded images. To ensure stable training and accurate geometry, we further propose a Depth-Guided Geometry Loss and a Multi-Stage Optimization strategy. We also construct a simulated benchmark with diverse spatial and temporal degradations and ground-truth appearances for comprehensive evaluation. Experiments on both simulated and real-world datasets show that MarineSTD-GS robustly handles spatiotemporal degradations and outperforms existing methods in novel view synthesis with realistic, water-free scene appearances.

Xiaoran Xu, Jiangang Yang, Wenyue Chong, Wenhui Shi, Shichu Sun, Jing Xing, Jian Liu

Single-Domain Generalized Object Detection(S-DGOD) aims to train an object detector on a single source domain while generalizing well to diverse unseen target domains, making it suitable for multimedia applications that involve various domain shifts, such as intelligent video surveillance and VR/AR technologies. With the success of large-scale Vision-Language Models, recent S-DGOD approaches exploit pre-trained vision-language knowledge to guide invariant feature learning across visual domains. However, the utilized knowledge remains at a coarse-grained level(e.g., the textual description of adverse weather paired with the image) and serves as an implicit regularization for guidance, struggling to learn accurate region- and object-level features in varying domains. In this work, we propose a new cross-modal feature learning method, which can capture generalized and discriminative regional features for S-DGOD tasks. The core of our method is the mechanism of Cross-modal and Region-aware Feature Interaction, which simultaneously learns both inter-modal and intra-modal regional invariance through dynamic interactions between fine-grained textual and visual features. Moreover, we design a simple but effective strategy called Cross-domain Proposal Refining and Mixing, which aligns the position of region proposals across multiple domains and diversifies them, enhancing the localization ability of detectors in unseen scenarios. Our method achieves new state-of-the-art results on S-DGOD benchmark datasets, with improvements of +8.8%mPC on Cityscapes-C and +7.9%mPC on DWD over baselines, demonstrating its efficacy. The code is available at https://github.com/startracker0/Boost.

Xinkui Lin, Yongxiu Xu, Minghao Tang, Shilong Zhang, Hongbo Xu, Hao Xu, Yubin Wang

Multimodal relation extraction (MRE) is a crucial task in the fields of Knowledge Graph and Multimedia, playing a pivotal role in multimodal knowledge graph construction. However, existing methods are typically limited to extracting a single type of relational triplet, which restricts their ability to extract triplets beyond the specified types. Directly combining these methods fails to capture dynamic cross-modal interactions and introduces significant computational redundancy. Therefore, we propose a novel unified multimodal Relation Extraction framework with Multilevel Optimal Transport and mixture-of-Experts, termed REMOTE, which can simultaneously extract intra-modal and inter-modal relations between textual entities and visual objects. To dynamically select optimal interaction features for different types of relational triplets, we introduce mixture-of-experts mechanism, ensuring the most relevant modality information is utilized. Additionally, considering that the inherent property of multilayer sequential encoding in existing encoders often leads to the loss of low-level information, we adopt a multilevel optimal transport fusion module to preserve low-level features while maintaining multilayer encoding, yielding more expressive representations. Correspondingly, we also create a Unified Multimodal Relation Extraction (UMRE) dataset to evaluate the effectiveness of our framework, encompassing diverse cases where the head and tail entities can originate from either text or image. Extensive experiments show that REMOTE effectively extracts various types of relational triplets and achieves state-of-the-art performanc on almost all metrics across two other public MRE datasets. We release our resources at https://github.com/Nikol-coder/REMOTE.

Xiaojian Lin, Wenxin Zhang 0005, Yuchu Jiang, Wangyu Wu, Yiran Guo, Kangxu Wang, Zongzheng Zhang, Guijin Wang, Lei Jin 0003, Hao Zhao 0002

Hierarchical feature representations play a pivotal role in computer vision, particularly in object detection for autonomous driving. Multi-level semantic understanding is crucial for accurately identifying pedestrians, vehicles, and traffic signs in dynamic environments. However, existing architectures, such as YOLO and DETR, struggle to maintain feature consistency across different scales while balancing detection precision and computational efficiency. To address these challenges, we propose Butter, a novel object detection framework designed to enhance hierarchical feature representations for improving detection robustness. Specifically, Butter introduces two key innovations: Frequency-Adaptive Feature Consistency Enhancement (FAFCE) Component, which refines multi-scale feature consistency by leveraging adaptive frequency filtering to enhance structural and boundary precision, and Progressive Hierarchical Feature Fusion Network (PHFFNet) Module, which progressively integrates multi-level features to mitigate semantic gaps and strengthen hierarchical feature learning. Through extensive experiments on BDD100K, KITTI, and Cityscapes, Butter demonstrates superior feature representation capabilities, leading to notable improvements in detection accuracy while reducing model complexity. By focusing on hierarchical feature refinement and integration, Butter provides an advanced approach to object detection that achieves a balance between accuracy, deployability, and computational efficiency in real-time autonomous driving scenarios. Our model and implementation are publicly available at https://github.com/Aveiro-Lin/Butter, facilitating further research and validation within the autonomous driving community.

Zhangchi Hu, Peixi Wu, Jie Chen 0001, Huyue Zhu, Yijun Wang, Yansong Peng, Hebei Li, Xiaoyan Sun 0001

Tiny object detection plays a vital role in drone surveillance, remote sensing, and autonomous systems, enabling the identification of small targets across vast landscapes. However, existing methods suffer from inefficient feature leverage and high computational costs due to redundant feature processing and rigid query allocation. To address these challenges, we propose Dome-DETR, a novel framework with Density-Oriented Feature-Query Manipulation for Efficient Tiny Object Detection. To reduce feature redundancies, we introduce a lightweight Density-Focal Extractor (DeFE) to produce clustered compact foreground masks. Leveraging these masks, we incorporate Masked Window Attention Sparsification (MWAS) to focus computational resources on the most informative regions via sparse attention. Besides, we propose Progressive Adaptive Query Initialization (PAQI), which adaptively modulates query density across spatial areas for better query allocation. Extensive experiments demonstrate that Dome-DETR achieves state-of-the-art performance (+3.3 AP on AI-TOD-V2 and +2.5 AP on VisDrone) while maintaining low computational complexity and a compact model size. Code is available at https://github.com/RicePasteM/Dome-DETR.

Rouqi Zhang, Chengdi Lu, Hancheng Lu, Yang Cao 0010, Tiesong Zhao

Embodied AI calls for a reliable, cross-modal object recognition that deeply mines High-Quality (HQ) object appearance (i.e., visual information) and touch details (i.e., haptic information). While in real-world scenarios, cross-modal data is usually degraded due to data acquisition and delivery in complex environments. In this paper, we propose a Robust Visual-Haptic recognition (RobustVisH) model that identifies Low-Quality (LQ) visual-haptic data with transmission distortion for the first time. First, we introduce the WIreless Transmission Interference-based Multi-modal benchmark (WITIM) as a visual-haptic dataset under transmission interference. In particular, the dataset consists of WITIM/AU and WITIM/PHAC-2, in which the original signals are obtained from AU and PHAC-2, respectively. Second, we design a trainable weighted fusion and a Transformer encoder based on the bi-directional self-attention mechanism, enabling RobustVisH to form and learn fused visual-haptic features after modality-specific one-dimensional feature encoding. Third, we employ a covariate shift paradigm, transferring knowledge of RobustVisH from HQ data to LQ data, thereby increasing its robustness against transmission-interference inputs. Experimental results demonstrate that the proposed RobustVisH improves the accuracy of the state-of-the-art method by 2.06% and 9.28% on WITIM/AU and WITIM/PHAC-2, respectively. Source code is available at: https://github.com/lylibylily/RobustVisH.

Songze Li, Yunfei Guo, Shen Chen 0004, Bin Li 0011, Kaiqing Lin, Changsheng Chen 0001, Haodong Li 0001, Taiping Yao, Shouhong Ding

Document Image Tampering Localization (DITL) advances considerably, yet achieving robust cross-dataset generalization remains a formidable challenge for practical applications. Expanding existing document datasets for training is labor-intensive, making it appealing to incorporate data from non-document domains such as natural scene images. However, domain-specific variations, including differences in color distribution and texture, compromise the performance of joint training. To address this issue, we propose DITL2, a Dual-stage Invariance Transfer Learning framework for Document Image Tampering Localization that consists of Cross-Domain Invariance Pre-training (CDIP) and Frequency Decoupling Parameter Adaptation (FDPA). In the pre-training stage, CDIP employs style transfer and texture consistency learning to suppress domain-specific influences from tampered natural scene images, and tampering trace commonality learning to acquire domain-invariant features. In the fine-tuning stage, FDPA adapts the parameters of the pre-trained model, leveraging the general knowledge from the pre-trained model to address DITL tasks while reducing the risk of overfitting. Experiments show that this approach effectively leverages external data resources to boost model performance, achieving state-of-the-art results across a variety of cross-dataset settings.

Junyu Zhou 0001, Yuyang Huang, Wenrui Dai, Junni Zou, Ziyang Zheng, Nuowen Kan, Chenglin Li, Hongkai Xiong

Recent prominence in 3D Gaussian Splatting (3DGS) has enabled real-time rendering while maintaining high-fidelity novel view synthesis. However, 3DGS resorts to the Gaussian function that is low-pass by nature and is restricted in representing high-frequency details in 3D scenes. Moreover, it causes redundant primitives with degraded training and rendering efficiency and excessive memory overhead. To overcome these limitations, we propose 3D Gabor Splatting (3DGabSplat) that leverages a novel 3D Gabor-based primitive with multiple directional 3D frequency responses for radiance field representation supervised by multi-view images. The proposed 3D Gabor-based primitive forms a filter bank incorporating multiple 3D Gabor kernels at different frequencies to enhance flexibility and efficiency in capturing fine 3D details. Furthermore, to achieve novel view rendering, an efficient CUDA-based rasterizer is developed to project the multiple directional 3D frequency components characterized by 3D Gabor-based primitives onto the 2D image plane, and a frequency-adaptive mechanism is presented for adaptive joint optimization of primitives. 3DGabSplat is scalable to be a plug-and-play kernel for seamless integration into existing 3DGS paradigms to enhance both efficiency and quality of novel view synthesis. Extensive experiments demonstrate that 3DGabSplat outperforms 3DGS and its variants using alternative primitives, and achieves state-of-the-art rendering quality across both real-world and synthetic scenes. Remarkably, we achieve up to 1.35 dB PSNR gain over 3DGS with simultaneously reduced number of primitives and memory consumption.

Guoyi Li, Die Hu 0004, Haozhe Li, Qirui Tang, Xiaomeng Fu, Yulei Wu, Xiaodan Zhang 0004, Honglei Lyu

In multimodal fact-checking, advanced large multimodal models (LMMs) struggle to capture and integrate the complex relationships between text and images. A potential solution is to generate reasoning support text to optimize reasoning and integrate evidence. However, existing generation approaches rely heavily on high-quality data annotations for training, which are costly and limited in scalability, hindering responsiveness to evolving misinformation. To address these issues, we propose CoReS, a novel zero-shot multimodal fact-checking model based on Conceptual Reasoning Support-leveraging key concepts from evidence to guide the reasoning process and improve decision-making. This model includes a reasoning support text generation module that extracts key concepts (critical elements that significantly impact the judgment outcome) from raw textual evidence via retrieval and filtering. By using a Conceptual Reasoning LM, CoReS generates reasoning support texts framed around core key concepts that are semantically consistent with multimodal evidence, linking key clues, thus replacing redundant and complex evidence for fact-checking. The reasoning support texts generated by CoReS effectively distill complex evidence relationships and integrate important reasoning information, allowing the judgment model to provide clear and accurate judgments. Evaluations on benchmark datasets and the new multi-domain MultiVerify dataset demonstrate that CoReS excels in accuracy, generalization, and scalability.

Hyungjun Doh, Dong In Lee, Seunggeun Chi, Pin-Hao Huang, Kwonjoon Lee, Sangpil Kim, Karthik Ramani

We introduce a novel framework for reconstructing dynamic human-object interactions from monocular video that overcomes challenges associated with occlusions and temporal inconsistencies. Traditional 3D reconstruction methods typically assume static objects or full visibility of dynamic subjects, leading to degraded performance when these assumptions are violated-particularly in scenarios where mutual occlusions occur. To address this, our framework leverages amodal completion to infer the complete structure of partially obscured regions. Unlike conventional approaches that operate on individual frames, our method integrates temporal context, enforcing coherence across video sequences to incrementally refine and stabilize reconstructions. This template-free strategy adapts to varying conditions without relying on predefined models, significantly enhancing the recovery of intricate details in dynamic scenes. We validate our approach using 3D Gaussian Splatting on challenging monocular videos, demonstrating superior precision in handling occlusions and maintaining temporal stability compared to existing techniques.

Han Hu 0009, Wenli Du, Bing Wang

In video anomaly detection task, to mitigate the interference of background noise on learning the appearance and motion features of foreground objects, existing object-centric methods often directly disregard scene information, making it challenging for them to detect scene-dependent anomalies. Moreover, we observe that most methods focus on reconstructing or predicting complete frame-level or object-level RGB information, which limits their inference speed. In this work, we propose a novel inter-frame RGB difference reconstruction network for efficient video anomaly detection. Specifically, we construct separate scene-dependent memory banks (SDMBs) for different scenes to store exclusive normal patterns, thus enabling sensitive detection of scene-dependent anomalies. Meanwhile, we design sparse aggregation and similarity-driven updating mechanisms for the memory items in the SDMBs, which effectively increase the reconstruction error of anomalies by adequately learning the diverse normal patterns in both the training and testing data, thus making the distinction between normal and abnormal frames easier. Extensive experiments on three public datasets demonstrate that our method outperforms state-of-the-art approaches in terms of detection accuracy, false negative rate, and inference speed, particularly in situations with more complex scene and event types.

Ye-Chan Kim, SeungJu Cha 0001, Si-Woo Kim, Taewhan Kim 0002, Dong-Jin Kim 0003

Zero-shot domain adaptation is a method for adapting a model to a target domain without utilizing target domain image data. To enable adaptation without target images, existing studies utilize CLIP's embedding space and text description to simulate target-like style features. Despite the previous achievements in zero-shot domain adaptation, we observe that these text-driven methods struggle to capture complex real-world variations and significantly increase adaptation time due to their alignment process. Instead of relying on text descriptions, we explore solutions leveraging image data, which provides diverse and more fine-grained style cues. In this work, we propose SIDA, a novel and efficient zero-shot domain adaptation method leveraging synthetic images. To generate synthetic images, we first create detailed, source-like images and apply image translation to reflect the style of the target domain. We then utilize the style features of these synthetic images as a proxy for the target domain. Based on these features, we introduce Domain Mix and Patch Style Transfer modules, which enable effective modeling of real-world variations. In particular, Domain Mix blends multiple styles to expand the intra-domain representations, and Patch Style Transfer assigns different styles to individual patches. We demonstrate the effectiveness of our method by showing state-of-the-art performance in diverse zero-shot adaptation scenarios, particularly in challenging domains. Moreover, our approach achieves high efficiency by significantly reducing the overall adaptation time.

Yuxiang Zhao 0002, Wei Huang 0050, Haipeng Zeng, Huan Zhao, Yujie Song

Human behavior has the nature of mutual dependencies, which requires human-robot interactive systems to predict surrounding agents' trajectories by modeling complex social interactions, avoiding collisions and executing safe path planning. While there exist many trajectory prediction methods, most of them do not incorporate the own motion of the ego agent and only model interactions based on static information. We are inspired by the humans' theory of mind during trajectory selection and propose a Cross time domain intention-interactive method for conditional Trajectory prediction(CiT). Our proposed CiT conducts joint analysis of behavior intentions over time, and achieves information complementarity and integration across different time domains. The intention in its own time domain can be corrected by the social interaction information from the other time domain to obtain a more precise intention representation. In addition, CiT is designed to closely integrate with robotic motion planning and control modules, capable of generating a set of optional trajectory prediction results for all surrounding agents based on potential motions of the ego agent. Extensive experiments demonstrate that the proposed CiT significantly outperforms the existing methods, achieving state-of-the-art performance in the benchmarks.

Mo Yang, Luo Chen, Jiali Zhou

Monitoring Earth's surface evolution is critical for understanding environmental processes and anthropogenic impacts, necessitating precise analysis of multi-temporal remote sensing data via integrated change detection and semantic interpretation. While existing methods achieve either pixel-level localization or semantic-level description, their conventional isolated frameworks exhibit two critical limitations: 1) inability to establish multimodal semantic consistency, and 2) feature confusion under complex environmental noise. To address these challenges, we propose Change-UP, a unified learning framework that synergizes Multilevel Change Interpretation (MCI) with Large Language Models (LLMs), enabling comprehensive analysis through dual visualization-inference perspectives. The architecture comprises three key components: 1) Adaptive Adjustment Change-Aware (A2CA) captures multi-scale inter-temporal differences through pyramidal feature fusion, significantly enhancing signal-to-noise ratio of differential features. 2) Query Semantic Consistency (QSC) establishes cross-modal alignment through learnable semantic queries, improving feature discrimination on challenging samples. 3) Style Transform Diversity (STD) integrates text-driven style transform with style synergy optimization to enhance inter-modal diversity while preventing feature space collapse. Extensive experiments demonstrate state-of-the-art performance, achieving 87.02% MIoU and CIDEr-D 143.40, surpassing previous methods by 0.59% and 3.11%, respectively. The framework's novel integration of visual-linguistic modalities opens new possibilities for intelligent Earth observation systems.

Haolun Li 0001, Weihuang Liu, Jiateng Liu, Zhenhua Tang, Chi-Man Pun, Qiguang Miao, Feng Xu 0005, Hao Gao 0005

Capturing human motion with existing monocular estimators often results in large errors when dealing with rare poses, occlusions, truncations, and frame blurring, leading to jitter and long-term drift. Although previous methods have introduced post-processing networks for pose refinement, they struggle to balance global smoothing and fine-grained correction. In this work, we propose MotionRefineNet, which leverages the synergy and complementarity between long- and short-term features in the temporal domain and high- and low-frequency features in the frequency domain to address these challenges. The temporal branch is designed as a hierarchical motion structure to learn multi-time scale features, where long-term features learn motion smoothness, and short-term features capture local rapid changes. The frequency branch employs different frequency band learning strategies based on the degrees of freedom (DoF) of body parts. For body parts with low DoF, the focus is on low-frequency features that represent overall motion trends and regular actions. For body parts with high DoF, we design a filter to adaptively extract useful information from all frequency bands, including subtle motion changes in the high-frequency bands. Extensive experiments on multiple datasets and estimators demonstrate that MotionRefineNet outperforms existing methods in refining 2D, 3D, and SMPL poses, achieving superior pose smoothing and deviation correction. Our code is available at: https://github.com/Wheels319/MotionRefineNet.

Steve Hodges 0001

In a world of generative models and large-scale data, it's insightful to revisit the intimate nature and unique value of personal multimedia through the lens of SenseCam - a wearable camera that automatically captures still images to create a visual diary for the wearer. Despite a variety of wearable camera products that have come to market in the decades since SenseCam was conceived, the unique properties of the original prototypes and the benefits these unlocked remain elusive today. Having explored why it has proven so challenging to move from a hardware prototype like SenseCam to a fully-fledged product with the same properties, I present a new phase of the prototyping-to-production journey I call isotyping. Isotyping shines a light on the critical, but often overlooked, steps necessary to scale from a promising prototype towards viable low-volume production. I call on the research community to help refine the concept and process of isotyping as we collectively continue to explore the potential of new forms of hardware in our research.

Tat-Seng Chua

AI as a concept has been around since the 1950s. With the recent advancements in machine learning technology, and the availability of big data and large computing resources, the scene is set for the explosive growth of AI. In particular, the emergence of Multimodal Foundation Models that offer significant capabilities in content comprehension, generation and reasoning has opened up opportunities for multimodal research and applications. The talk first reviews the trends and developments in Multimodal Foundation Models. It then outlines the advances in multilingual and multimodal alignments and discusses the emergence of language- and media-agnostic signals that appear to represent abstract concepts commonly used in human languages. These signals have been shown to have a positive impact on both the performance and safety of the resulting models, especially in enhancing those with low-training samples. To further improve the performance of the models, most current approaches employ reinforcement learning with various reward functions to achieve better controllable content generation and trust. To facilitate effective reinforcement learning, quality assessment is of pivotal importance, while it has largely been overlooked. This talk further presents recent approaches to quality assessment and its role in the generation of textual descriptions, videos, and 3D media. As research on Multimodal Foundation Models is still in an early stage, this talk concludes with directions for future research.

Shalini De Mello

Humans are innately social creatures with a need to interact with others. The advent of AI has profoundly advanced technologies for human interaction. It has not only opened the doors to seamless human-to-machine interaction but has also helped to significantly enhance human-to-human digital interaction, bringing people together in more engaging and immersive ways. This talk will trace a decade-long progression of the development of cutting-edge AI-mediated technologies for human-to-machine and human-to-human interaction. There are two fundamental aspects to solving this problem -- human understanding and human synthesis. This talk will seek to answer the question of how far along we've come in solving both, along with what the underlying AI building blocks are that have helped us get here. It will further highlight the successful application areas of AI-mediated human interaction technologies that are positively impacting people's lives. Lastly, it will conclude with thoughts on what is left on the table in terms of research and innovation, and speculate on what the next frontier will be for profound real-world impact in this space.