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Applications · Health

Max Lamparth, Declan Grabb, Amy Franks, Scott Gershan, Kaitlyn Kunstman, Aaron Lulla, Monika Roots, Manu Sharma, Aryan Shrivastava, Nina Vasan 等

Current medical language model (LM) benchmarks often over-simplify the complexities of day-to-day clinical practice tasks and instead rely on evaluating LMs on multiple-choice board exam questions. In psychiatry especially, these challenges are worsened by fairness and bias issues, since models can be swayed by patient demographics even when those factors should not influence clinical decisions. Thus, we present an expert-created and annotated dataset spanning five critical domains of decision-making in mental healthcare: treatment, diagnosis, documentation, monitoring, and triage. This U.S. centric dataset — created without any LM assistance — is designed to capture the nuanced clinical reasoning and daily ambiguities mental health practitioners encounter, reflecting the inherent complexities of care delivery that are missing from existing datasets. Almost all base questions with five answer options each have had the decision-irrelevant demographic patient information removed and replaced with variables, e.g., for age or ethnicity, and are available for male, female, or non-binary-coded patients. This design enables systematic evaluations of model performance and bias by studying how demographic factors affect decision-making. For question categories dealing with ambiguity and multiple valid answer options, we create a preference dataset with uncertainties from the expert annotations. We outline a series of intended use cases and demonstrate the usability of our dataset by evaluating sixteen off-the-shelf and six (mental) health fine-tuned LMs on category-specific task accuracy, on the fairness impact of patient demographic information on decision-making, and how consistently free-form responses deviate from human-annotated samples.

Applications · Health

Michael Yao, Osbert Bastani, Alma Andersson, Tommaso Biancalani, Aicha BenTaieb, Claudia Iriondo

The goal of personalized medicine is to discover a treatment regimen that optimizes a patient's clinical outcome based on their personal genetic and environmental factors. However, candidate treatments cannot be arbitrarily administered to the patient to assess their efficacy; we often instead have access to an *in silico* surrogate model that approximates the true fitness of a proposed treatment. Unfortunately, such surrogate models have been shown to fail to generalize to previously unseen patient-treatment combinations. We hypothesize that domain-specific prior knowledge—such as medical textbooks and biomedical knowledge graphs—can provide a meaningful alternative signal of the fitness of proposed treatments. To this end, we introduce **L**LM-based **E**ntropy-guided **O**ptimization with k**N**owledgeable priors (**LEON**), a mathematically principled approach to leverage large language models (LLMs) as black-box optimizers without any task-specific fine-tuning, taking advantage of their ability to contextualize unstructured domain knowledge to propose personalized treatment plans in natural language. In practice, we implement LEON via 'optimization by prompting,' which uses LLMs as stochastic engines for proposing treatment designs. Experiments on real-world optimization tasks show LEON outperforms both traditional and LLM-based methods in proposing individualized treatments for patients.

Applications · Genetics, Cell Biology, Health, etc

Vidit Agrawal, John Peters, Tyler Thompson, Mohammad Sanian, Chau Pham, Nikita Moshkov, Arshad Kazi, Aditya Pillai, Jack Freeman, Byunguk Kang 等

Quantifying cell morphology using images and machine learning has proven to be a powerful tool to study the response of cells to treatments. However, models used to quantify cellular morphology are typically trained with a single microscopy imaging type. This results in specialized models that cannot be reused across biological studies because the technical specifications do not match (e.g., different number of channels). Here, we present CHAMMI-75, an open access dataset of heterogeneous, multi-channel microscopy images from 75 diverse biological studies. We curated this resource from publicly available sources to investigate cellular morphology models that are channel-adaptive and can process any microscopy image type. Our experiments show that training with CHAMMI-75 can improve performance in multi-channel bioimaging tasks primarily because of its high diversity in microscopy modalities. This work paves the way to create the next generation of cellular morphology models for biological studies.

Wei Zhou 0021, Hadi Amirpour, Li Yu 0004, Jungong Han, Richang Hong, Paul L. Rosin

Recent years have witnessed an unprecedented growth of multimodal data in healthcare, ranging from distributed sensors and medical imaging devices (MRI, CT, X-rays) to digital health platforms that integrate audio, video, 3D geometry, and clinical text. The increasing availability of such data presents significant opportunities for computer-aided diagnosis and intelligent healthcare solutions, yet also poses substantial challenges in multimodal integration, large-scale analysis, and real-world deployment. The 2nd International Workshop on Multimedia Computing for Health and Medicine (MCHM'25), held in conjunction with ACM Multimedia 2025, focuses on advanced multimedia computing techniques, including mobile and hardware solutions, for tackling real-world problems in healthcare. The workshop brings together researchers and practitioners in multimedia computing, artificial intelligence, and medicine to explore emerging methods, applications, and systems that have a direct impact on human health.

Zixiang Wang, Yinghao Zhu, Huiya Zhao, Xiaochen Zheng, Dehao Sui, Tianlong Wang, Wen Tang 0001, Yasha Wang, Ewen M. Harrison, Chengwei Pan 等

We introduce ColaCare, a framework that enhances Electronic Health Record (EHR) modeling through multi-agent collaboration driven by Large Language Models (LLMs). Our approach seamlessly integrates domain-specific expert models with LLMs to bridge the gap between structured EHR data and text-based reasoning. Inspired by the Multidisciplinary Team (MDT) approach used in clinical settings, ColaCare employs two types of agents: DoctorAgents and a MetaAgent, which collaboratively analyze patient data. Expert models process and generate predictions from numerical EHR data, while LLM agents produce reasoning references and decision-making reports within the MDT-driven collaborative consultation framework. The MetaAgent orchestrates the discussion, facilitating consultations and evidence-based debates among DoctorAgents, simulating diverse expertise in clinical decision-making. We additionally incorporate the Merck Manual of Diagnosis and Therapy (MSD) medical guideline within a retrieval-augmented generation (RAG) module for medical evidence support, addressing the challenge of knowledge currency. Extensive experiments conducted on three EHR datasets demonstrate ColaCare's superior performance in clinical mortality outcome and readmission prediction tasks, underscoring its potential to revolutionize clinical decision support systems and advance personalized precision medicine. All code, case studies and a questionnaire are available at the project website: https://colacare.netlify.app.

Yanzeng Li, Cheng Zeng, Jinchao Zhang, Jie Zhou, Lei Zou

Medical education relies heavily on Simulated Patients (SPs) to provide a safe environment for students to practice clinical skills, including medical image analysis. However, the high cost of recruiting qualified SPs and the lack of diverse medical imaging datasets have presented significant challenges. To address these issues, this paper introduces MedDiT, a novel knowledge-controlled conversational framework that can dynamically generate plausible medical images aligned with simulated patient symptoms, enabling diverse diagnostic skill training. Specifically, MedDiT integrates various patient Knowledge Graphs (KGs), which describe the attributes and symptoms of patients, to dynamically prompt Large Language Models' (LLMs) behavior and control the patient characteristics, mitigating hallucination during medical conversation. Additionally, a well-tuned Diffusion Transformer (DiT) model is incorporated to generate medical images according to the specified patient attributes in the KG. In this paper, we present the capabilities of MedDiT through a practical demonstration, showcasing its ability to act in diverse simulated patient cases and generate the corresponding medical images. This can provide an abundant and interactive learning experience for students, advancing medical education by offering an immersive simulation platform for future healthcare professionals. The work sheds light on the feasibility of incorporating advanced technologies like LLM, KG, and DiT in education applications, highlighting their potential to address the challenges faced in simulated patient-based medical education.

Yasmeena Akhter

With approximately 2 billion chest X-ray examinations conducted globally each year, the demand for radiological interpretation far surpasses the available expertise, particularly in resource-constrained regions. Recent advancements in artificial intelligence and computer vision present promising solutions for automated chest X-ray analysis. Nevertheless, integrating AI-driven diagnostics into clinical practice encounters several challenges, including data-centric issues, implementation barriers, deployment complexities, and the need for trustworthy AI. This dissertation focuses on the data-centric aspect, making significant contributions through enhanced data collection, the creation of novel datasets, algorithm development, privacy-preserving collaborative learning, and modelling for low-resolution data. It offers practical methodologies for embedding AI into chest radiology workflows, with a particular emphasis on addressing underserved conditions and healthcare settings with limited data availability. Furthermore, this work illustrates how tailored AI solutions can democratize access to high-quality radiological care while balancing privacy considerations and operational constraints across diverse environments.

Hongwei Sheng, Heming Du, Xin Shen, Sen Wang, Xin Yu

Retina images provide a noninvasive view of the central nervous system and microvasculature, making it essential for clinical applications. Changes in the retina often indicate both ophthalmic and systemic diseases, aiding in diagnosis and early intervention. While deep learning algorithms have advanced retina image analysis, a comprehensive review of related datasets, tasks, and benchmarking is still lacking. In this survey, we systematically categorize existing retina image datasets based on their available data modalities, and review the tasks these datasets support in multimodal retina image analysis. We also explain key evaluation metrics used in various retina image analysis benchmarks. By thoroughly examining current datasets and methods, we highlight the challenges and limitations in existing benchmarks and discuss potential research topics in the field. We hope this work will guide future retina analysis methods and promote the shared use of existing data across different tasks.

Anisio Lacerda, Gisele Pappa, Adriano César Machado Pereira, Wagner Meira Jr, Alexandre Guimarães de Almeida Barros

The integration of Large Language Models (LLMs) into medicine presents both great opportunities and significant challenges, particularly in ensuring these models are accurate, reliable, and safe. While LLMs have shown impressive capabilities in understanding and generating human language, their application in the medical domain requires careful evaluation due to the critical nature of medical applications which are inherently linked to patient life and health. Current evaluations of LLMs in medicine are often fragmented and insufficient, with a lack of standardized performance metrics, limited use of real patient data, and insufficient attention to important applications, such as documentation, education, and research. Furthermore, traditional NLP-based evaluations are often inadequate for assessing the text generated by LLMs. Therefore, a robust evaluation is essential to ensure the responsible and effective use of LLMs in medical settings, and to address the inherent challenges associated with their implementation. This paper explores the various dimensions of LLM evaluation in the medical domain, proposes a new taxonomy for categorizing medical applications, and discusses directions for future research in this critical area.

Tianren Zhou, Zhenge Jia, Dongxiao Yu, Zhaoyan Shen

Arrhythmia diagnosis using electrocardiogram (ECG) is critical for preventing cardiovascular risks. However, existing deep learning-based methods struggle with label scarcity and contrastive learning-based methods suffer from false-negative samples, which lead to poor model generalization. Besides, due to inter-subject variability, pre-trained models cannot achieve evenly performance across individuals. Conducting model fine-tuning for each individual is computationally expensive and does not guarantee improvement. We propose DiffECG, a diffusion-based self-supervised learning framework for label-efficient and personalized arrhythmia detection. Our method utilizes a diffusion model to extract robust ECG representations, coupled with a novel feature extractor and a multi-modal feature fusion strategy to obtain a well-generalized model. Moreover, we propose an efficient model personalization mechanism based on zeroth-order optimization. It personalizes the model by tuning the noise-adding step t in the diffusion process, significantly reducing computational costs compared to model fine-tuning. Experimental results show that our proposed method outperforms the SOTA method by 37.9% and 23.9% in generalization and personalization performance, respectively. The source code is available at: https://github.com/Auguuust/DiffEC

Linyun Zhou, Jiacong Hu, Shengxuming Zhang, Xiangtong Du, Mingli Song, Xiuming Zhang, Zunlei Feng

Dense object segmentation is essential for various applications, particularly in pathology image and remote sensing image analysis. However, distinguishing numerous similar and densely packed objects in this task presents significant challenges. Several methods, including CNN- and ViT-based approaches, have been proposed to tackle these issues. Yet, models trained on limited datasets exhibit limited generalization ability. The Segment Anything Model (SAM) has recently achieved significant progress in zero-shot segmentation but relies heavily on precise positional guidance. However, providing numerous accurate location prompts in dense scenarios is time-consuming. To overcome this limitation, we conducted an in-depth exploration of the SAM mechanism and found that its strong generalization ability stems from the encoder’s edge detection capability, which is semantically independent, making location prompts essential for segmentation. This insight inspired the development of DenseSAM, which replaces location prompts with semantic guidance for automatic segmentation in dense scenarios. Specifically, it uses local details to weaken the edges of background objects, leverages global context to enhance intra-class feature similarity, while further increasing contrast with the background, and integrates a dual-head decoding process to enable lightweight automatic semantic segmentation. Extensive experiments on pathology images demonstrate that DenseSAM delivers remarkable performance with minimal training parameters, providing a cost-effective and efficient solution. Moreover, experiments on remote sensing images further validate its excellent scalability, making DenseSAM suitable for various dense object segmentation domains. The code is available at https://github.com/imAzhou/DenseSAM.

Enshang Zhang, Zhicheng Zhang, Takashi Hanakawa

Reconstructing visual stimuli from EEG signals is a crucial step in realizing brain-computer interfaces. In this paper, we propose a transformer-based EEG signal encoder integrating the Discrete Wavelet Transform (DWT) and the gating mechanism. Guided by the feature alignment and category-aware fusion losses, this encoder is used to extract features related to visual stimuli from EEG signals. Subsequently, with the aid of a pre-trained diffusion model, these features are reconstructed into visual stimuli. To verify the effectiveness of the model, we conducted EEG-to-image generation and classification tasks using the THINGS-EEG dataset. To address the limitations of quantitative analysis at the semantic level, we combined WordNet-based classification and semantic similarity metrics to propose a novel semantic-based score, emphasizing the ability of our model to transfer neural activities into visual representations. Experimental results show that our model significantly improves semantic alignment and classification accuracy, which achieves a maximum single-subject accuracy of 43%, outperforming other state-of-the-art methods. The source code is available at https://github.com/zes0v0inn/DWT_EEG_Reconstruction/.

Jiexia Ye, Weiqi Zhang, Ziyue Li, Jia Li, Meng Zhao, Fugee Tsung

The recent rapid advancements in language models (LMs) have garnered attention in medical time series-text multimodal learning. However, existing contrastive learning-based and prompt-based LM approaches tend to be biased, often assigning a primary role to time series modality while treating text modality as secondary. We classify these approaches under a temporal-primary paradigm, which may overlook the unique and critical task-relevant information embedded in text modality like clinical reports, thus failing to fully leverage mutual benefits and complementarity of different modalities. To fill this gap, we propose a novel textual-temporal multimodal learning paradigm that enables either modality to serve as the primary while being enhanced by the other, thereby effectively capturing modality-specific information and fostering cross-modal interaction. In specific, we design MedualTime, a language model composed of dual adapters to implement temporal-primary and textual-primary modeling simultaneously. Within each adapter, lightweight adaptation tokens are injected into the top layers of LM to encourage high-level modality fusion. The shared LM pipeline by dual adapters not only achieves adapter alignment but also enables efficient fine-tuning, reducing computational resources. Empirically, MedualTime demonstrates superior performance on medical data, achieving notable improvements of 8% accuracy and 12% F1 in supervised settings. Furthermore, MedualTime's transferability is validated by few-shot transfer experiments from coarse-grained to fine-grained medical data.

Bo Xu, Quanhao Zhu, Qingchen Zhang, Mengmeng Wang, Liang Zhao, Hongfei Lin, Jing Ren, Feng Xia

With the development of wearable cardiac ultrasound devices, it is no longer sufficient to solely rely on doctors for diagnosing long-term echocardiogram videos. Automated diagnosis of echocardiogram videos has now become a research hotspot. Existing studies only analyze echocardiogram video through discriminative models, which have limited question-answering capabilities. Therefore, this study innovatively proposes a large language model with cardiac ultrasound diagnostic capabilities—EchoGPT. EchoGPT integrates the robust communication and comprehension capabilities of large language models (LLMs) with the diagnostic prowess of traditional medical models, empowering patients to obtain accurate medical indicator data and comprehend their health conditions through interactive questioning with the model. The model is capable of local deployment on personal computers, effectively safe guarding user privacy. EchoGPT operates through three main components: left ventricle segmentation, left ventricular ejection fraction LVEF prediction, and finetuning of video-text LLMs. Experimental results demonstrate EchoGPT’s superior accuracy in predicting LVEF compared to other models, and positive feedback from professional physicians through questionnaire surveys, validating its potential in practical applications. The demo is available at https://github.com/zhuqh19/EchoGPT.

Feiyue Wu, Tianxing Wu, Shenqi Jing

Medication recommendation is a crucial task in healthcare, especially for patients with complex medical conditions. However, existing methods often struggle to effectively balance the reuse of historical medications with the introduction of new drugs in response to the changing patient conditions. In order to address this challenge, we propose an Adaptively Responsive network for Medication Recommendation (ARMR), a new method which incorporates 1) a piecewise temporal learning component that distinguishes between recent and distant patient history, enabling more nuanced temporal understanding, and 2) an adaptively responsive mechanism that dynamically adjusts attention to new and existing drugs based on the patient's current health state and medication history. Experiments on the MIMIC-III and MIMIC-IV datasets indicate that ARMR has better performance compared with the state-of-the-art baselines in different evaluation metrics, which contributes to more personalized and accurate medication recommendations. The source code is publicly avaiable at: https://github.com/seucoin/armr2.

Dung Nguyen, Minh Khoi Ho, Huy Ta, Thanh Tam Nguyen, Qi Chen, Kumar Rav, Quy Duong Dang, Satwik Ramchandre, Son Lam Phung, Zhibin Liao 等

Medical Large Multi-modal Models (LMMs) have demonstrated remarkable capabilities in medical data interpretation. However, these models frequently generate hallucinations contradicting source evidence, particularly due to inadequate localization reasoning. This work reveals a critical limitation in current medical LMMs: instead of analyzing relevant pathological regions, they often rely on linguistic patterns or attend to irrelevant image areas when responding to disease-related queries. To address this, we introduce HEAL-MedVQA (Hallucination Evaluation via Localization MedVQA), a comprehensive benchmark designed to evaluate LMMs' localization abilities and hallucination robustness. HEAL-MedVQA features (i) two innovative evaluation protocols to assess visual and textual shortcut learning, and (ii) a dataset of 67K VQA pairs, with doctor-annotated anatomical segmentation masks for pathological regions. To improve visual reasoning, we propose the Localize-before-Answer (LobA) framework, which trains LMMs to localize target regions of interest and self-prompt to emphasize segmented pathological areas, generating grounded and reliable answers. Experimental results demonstrate that our approach significantly outperforms state-of-the-art biomedical LMMs on the challenging HEAL-MedVQA benchmark, advancing robustness in medical VQA.

Anchen Lin, Weikun Wang, Haijun Han, Fanwei Zhu, Qi Ma, Zengwei Zheng, Binbin Zhou

Major Depressive Disorder (MDD) is a prevalent and severe mental disease. Functional Magnetic Resonance Imaging (fMRI)-based diagnostic methods, which analyze Functional Connectivity (FC) to identify abnormal functional connections, have shown promise as biomarker-based approaches for diagnosing depression. However, the high costs of fMRI data result in small sample sizes, hindering the effective identification of abnormal FC patterns. Moreover, existing methods often overlook the potential benefits of incorporating domain knowledge into their models. In this paper, we propose KnowMDD, a novel knowledge-guided cross contrastive learning framework for MDD diagnosis. By incorporating domain knowledge and employing data augmentation, KnowMDD addresses data sparsity while improving robustness and interpretability. Specifically, multiple atlases are used to construct complementary brain graph representations. The default mode network, closely associated with depression, is introduced into the contrastive learning paradigm for diverse subgraph augmentations, while an attention mechanism captures global semantic relationships between brain regions. Based on them, a cross contrastive learning is designed to learn robust representations for accurate diagnosis. Extensive experiments demonstrate the effectiveness, robustness, and interpretability of KnowMDD, which outperforms state-of-the-art methods. We also develop a demonstration system to show its practical application.

Xinjie Li, Abhinav Verma

Single-step retrosynthesis is a crucial task in organic synthesis, where the objective is to identify the reactants needed to produce a given product. In recent years, a variety of machine learning methods have been developed to tackle retrosynthesis prediction. In our study, we introduce RetroMoE, a novel generative model designed for the single-step retrosynthesis task. We start with a non-symmetric variational autoencoder (VAE) that incorporates a graph encoder to map molecular graphs into a latent space, followed by a transformer decoder for precise prediction of molecular SMILES strings. Additionally, we implement a simple yet effective mixture-of-experts (MoE) network to translate the product latent embedding into the reactant latent embedding. To our knowledge, this is the first approach that frames single-step retrosynthesis as a latent translation problem. Extensive experiments on the USPTO-50K and USPTO-MIT datasets demonstrate the superiority of our method, which not only surpasses most semi-template-based and template-free methods but also delivers competitive results against template-based methods. Notably, under the class-known setting on the USPTO-50K, our method achieves top-1 exact match accuracy comparable to the state-of-the-art template method, RetroKNN.

Xiaodi Hou, Xiaobo Li, Mingyu Lu, Simiao Wang, Yijia Zhang

Recent advancements in radiology report generation have utilized deep neural networks such as CNNs and Transformers, achieving notable improvements in generating accurate and detailed reports. However, their practical adoption is hindered by the challenge of balancing global dependency modeling with computational efficiency. The state space model, particularly its enhanced variant Mamba, offers promising linear-complexity solutions for long-range dependency modeling. Despite its strengths, Mamba’s fixed positional encoding limits its ability to effectively capture complex spatial dependencies. To address this gap, we propose RRG-Mamba, an advanced framework for efficient radiology report generation. Within the RRGMamba, we enhance the vanilla Mamba by integrating rotary position encoding (RoPE), enabling dynamic modeling of relative positional information in visual feature sequences. Furthermore, we design a global dependency learning module to optimize long-range visual feature sequence modeling. Extensive experiments on publicly available datasets, including IU X-Ray and MIMIC-CXR, demonstrate that RRG-Mamba achieves a 3.7% improvement in BLEU-4 score over existing models, along with significant gains in computational and memory efficiency. Our code is available at https://github.com/Eleanorhxd/RRG-Mamba.

Shaolong Wei, Shu Jiang, Mingliang Wang, Liang Sun, Haonan Rao, Weiping Ding, Jiashuang Huang

Structural-functional coupling (SC-FC coupling) offers an effective approach for analyzing structural-functional relationships, capable of revealing the dependency of functional activity on the underlying white matter architecture. However, extant SC-FC coupling analysis methods primarily center on disclosing the statistical association between the topological patterns of structural connectivity (SC) and functional connectivity (FC), while often neglecting the neurobiological mechanisms by which the brain typically transmits and processes information in the form of spikes. To address this, we propose a biologically inspired deep-learning model called spike-based coupling neural networks (SCNNs). It can simulate spiking neural activity to more realistically reproduce the interaction between brain regions and the dynamic behavior of neuronal networks. Specifically, we first use spike neurons to capture the FC temporal characteristics of the original functional magnetic resonance imaging (fMRI) time series and the SC spatial characteristics of the structural brain network. Then, we use synaptic and neuronal filter effects to simulate the coupling mechanism of SC and FC in the brain at different temporal and spatial scales, thereby quantifying SC-FC coupling and providing support for the identification of brain diseases. The results on real datasets show that the proposed method can identify brain diseases and provide a new perspective for understanding SC-FC relationships.