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Zi-Hao Bo, Yaqian Li, Anzhou Hou, Rinyoichi Takezoe, Ertao Zhao, Tianxiang Pan, Jiale Yan, Mo Guang, Kaiwen Long

Mixture-of-Experts (MoE) has become a prevalent backbone for large vision-language models (VLMs), yet how modality-specific signals should guide expert routing remains under-explored. Existing routing strategies are either hand-crafted or modality-agnostic, relying on idealized priors that ignore the layer-dependent modality fusion patterns in MoE-VLMs and provide little guidance for expert specialization. We propose Soft Modality-guided Expert Specialization (SMoES), which consists of dynamic soft modality scores that capture layer-dependent fusion patterns, an expert binning mechanism aligned with expert-parallel deployment, and an inter-bin mutual information regularization that encourages coherent modality specialization. Our method leverages attention-based or Gaussian-statistics modality scores to optimize mutual information regularization. Experiments across four MoE-based VLMs and 16 benchmarks demonstrate improvement on both effectiveness and efficiency: 0.9% and 4.2% average gain on multimodal and language-only tasks, 56.1% reduction in EP communication overhead, and 12.3% throughput improvement under realistic deployment. These results validate that aligning routing with modality-aware expert specialization unlocks MoE-VLM capacity and efficiency.

Jiazhong Cen, Jiemin Fang, Sikuang Li, Guanjun Wu, Chen Yang, Taoran Yi, Zanwei Zhou, Zhikuan Bao, Lingxi Xie, Wei Shen 等

High-quality 3D assets are critical for VR/AR, industrial design, and entertainment, driving growing interest in generative models that can create 3D content from user-provided prompts. Most existing 3D generators, however, rely on a single conditioning modality: image-conditioned models deliver high visual fidelity by exploiting pixel-aligned cues but suffer from viewpoint bias when the input view is limited or ambiguous, whereas text-conditioned models benefit from broad semantic guidance yet lack low-level visual detail. This restricts how users can express their intent and raises a natural question: can the two modalities be combined to yield more flexible and faithful 3D generation? Our diagnostic study shows that even a simple late fusion of text- and image-conditioned predictions improves over single-modality models, evidencing strong cross-modal complementarity. Building on this finding, we formalize the task of Text-Image Conditioned 3D Generation, which requires joint reasoning over a visual exemplar and a textual specification during generation. To address this task, we introduce TIGON, a minimalist dual-branch baseline that maintains separate image- and text-conditioned backbones with lightweight cross-modal fusion. Extensive experiments demonstrate that text-image conditioning yields consistent gains over single-modality methods, suggesting complementary vision-language guidance as a promising direction for future 3D generation research.

Zhengyang Sun, Yu Chen, Xin Zhou, Xiaofan Li, Xiwu Chen, Dingkang Liang, Xiang Bai

Text-to-video diffusion models have enabled open-ended video synthesis, but often struggle with generating the correct number of objects specified in a prompt. We introduce NUMINA, a training-free identify-then-guide framework for improved numerical alignment. NUMINA identifies prompt-layout inconsistencies by selecting discriminative self- and cross-attention heads to derive a countable latent layout. It then refines this layout conservatively and modulates cross-attention to guide regeneration. On the introduced CountBench, NUMINA improves counting accuracy by up to 7.4% on Wan2.1-1.3B, and by 4.9% and 5.5% on 5B and 14B models, respectively. Furthermore, CLIP alignment is improved while maintaining temporal consistency. These results demonstrate that structural guidance complements seed search and prompt enhancement, offering a practical path toward count-accurate text-to-video diffusion. The code is available at https://github.com/H-EmbodVis/NUMINA.

Shihao Shan, Hongying Liu, Fanhua Shang, Liang Wan, Jingjing Deng

All-in-one Medical Image Restoration (MedIR) models offer a promising path towards generalized medical imaging intelligence but face two critical spatiotemporal challenges: 1) Spatial modality interference, where conflicting gradients from diverse modalities (e.g., MRI, CT, PET) degrade performance; and 2) a temporal static-world assumption that ignores the continual data streams in real-world clinical settings, leading to catastrophic forgetting. To address this dual challenge, we propose a novel lifelong learning framework (called Resilient On-the-fly Medical Enhancement, ROME) governed by a "disentangle-optimize-consolidate" paradigm. ROME first resolves the foundational modality conflict via the Modality-Invariant Disentanglement via Adversarial Balancing (MIDAB) module. It establishes a strategic "adversarial balance" between a "content preservation force" and a "modality erasure force" to optimize a disentangled, unified feature manifold. Building on this stable foundation, the Adaptive Feature Consolidation (AFC) module combats forgetting. AFC dynamically locates an optimal feature consolidation point via a prediction network, enforced by a novel diversity loss to ensure robust continuous learning. Experiments demonstrate that ROME not only achieves SOTA performance in static settings but also exhibits superior resilience in rigorous domain-incremental benchmarks, reducing the average catastrophic performance degradation by over 10%.

Pushpak Pati, Bo Li, Abbas Rayabat Khan, Tomé Albuquerque, Steffen Jaensch, Amina Mollaysa, Walid M. Abdelmoula, Samantha J. Allen, Joke Reumers, Helai P. Mohammad 等

Compound activity modeling is critical for drug discovery, where accurate *in silico* predictions can significantly reduce reliance on expensive, time-consuming target-specific experimental assays. Traditional machine learning approaches for compound activity modeling typically rely on either chemoproteomics-centric molecular data or phenotype-centric imaging screens, limiting their ability to capture complementary biological signals. While multimodal approaches show promise, they often fail to capture the interplay between molecular mechanisms and cellular responses. In this paper, we present **BiGMINT**, a **Bi**ologically **G**uided **M**ultimodal framework that hierarchically **INT**egrates chemoproteomic and high-content imaging (HCI) data, introducing chemoproteomics-guided phenotypic aggregation, task-aware cross-modal fusion, and protein-protein interaction priors for modeling activities. On two large-scale in-house datasets, with 99K and 40K compound-HCI pairs from U2OS and iNeuron, **BiGMINT** improves mean AUCROC by up to 10.0% and 4.2%, and high-performing task coverage by up to 103% and 56% over best unimodal and multimodal methods. Thorough analysis revealed mechanistic insights, showing these gains stem from modality complementarity, and protein-protein priors enhance modeling of challenging activities.

Dmytro Kotovenko, Olga Grebenkova, Björn Ommer

3D Gaussian Splatting reconstructs scenes by starting from a sparse Structure-from-Motion initialization and refiningunder-reconstructed regions. This process is slow, as it requires multiple densification steps where Gaussians arerepeatedly split and adjusted, following a lengthy optimization path. Moreover, this incremental approach often yieldssuboptimal renderings in high-frequency regions. We propose a fundamentally different approach: eliminate densification with a one-step approximation of scenegeometry using triangulated pixels from dense image correspondences. This dense initialization allows us to estimatethe rough geometry of the scene while preserving rich details from input RGB images, providing each Gaussian withwell-informed color, scale, and position. As a result, we dramatically shorten the optimization path and remove theneed for densification. Unlike methods that rely on sparse keypoints, our dense initialization ensures uniform detailacross the scene, even in high-frequency regions where other methods struggle. Moreover, since all splats are initializedin parallel at the start of optimization, we remove the need to wait for densification to adjust new Gaussians.EDGS reaches LPIPS and SSIM performance of standard 3DGS significantly faster than existing efficiency-focused approaches. When trained further, it exceeds the reconstruction quality of state-of-the-art models aimed at maximizing fidelity. Our method is fully compatible with other acceleration techniques, making it a versatile and efficient solution that can be integrated with existing approaches.

Rui Peng, Ziru Liu, Lingyuan Ye, Yuxing Lu, Boxin Shi, Jinzhuo Wang

Accurately modeling the relationship between perturbations, transcriptional responses, and phenotypic changes is essential for building an AI Virtual Cell (AIVC). However, existing methods typically constrained to modeling direct associations, such as *Perturbation -> RNA* or *Perturbation -> Morphology*, overlook the crucial causal link from RNA to morphology. To bridge this gap, we propose TRIDENT, a cascade generative framework that synthesizes realistic cellular morphology by conditioning on both the perturbation and the corresponding gene expression profile. To train and evaluate this task, we construct MorphoGene, a new dataset pairing L1000 gene expression with Cell Painting images for 98 compounds. TRIDENT significantly outperforms state-of-the-art approaches, achieving up to 7-fold improvement with strong generalization to unseen compounds. In a case study on docetaxel, we validate that RNA-guided synthesis accurately produces the corresponding phenotype. An ablation study further confirms that this RNA conditioning is essential for the model's high fidelity. By explicitly modeling transcriptome-phenome mapping, TRIDENT provides a powerful in silico tool and moves us closer to a predictive virtual cell.

Jiin Im, Sisung Liu, Je Hyeong Hong

Semantic correspondence is essential for handling diverse in-the-wild images lacking explicit correspondence annotations. While recent 2D foundation models offer powerful features, adapting them for unsupervised learning via nearest-neighbor pseudo-labels has key limitations: it operates locally, ignoring structural relationships, and consequently its reliance on 2D appearance fails to resolve geometric ambiguities arising from symmetries or repetitive features. In this work, we address this by reformulating pseudo-label generation as a Fused Gromov-Wasserstein (FGW) problem, which jointly optimizes inter-feature similarity and intra-structural consistency. Our framework, Shape-of-You (SoY), leverages a 3D foundation model to define this intra-structure in the geometric space, resolving abovementioned ambiguity. However, since FGW is a computationally prohibitive quadratic problem, we approximate it through anchor-based linearization. The resulting probabilistic transport plan provides a structurally consistent but noisy supervisory signal. Thus, we introduce a soft-target loss dynamically blending guidance from this plan with network predictions to build a learning framework robust to this noise. SoY achieves state-of-the-art performance on SPair-71k and AP-10k datasets, establishing a new benchmark in semantic correspondence without explicit geometric annotations. Code is available at Shape-of-You.

Caiyang Yu, Chen Huang, Yun Liu, Chenwei Tang, Wei Ju, Jiancheng Lv

As a representative technique in neural architecture search, neural architecture generation aims to construct high-performance architectures for a given task directly. It is poised to replace the inefficient random exploration components of some search strategies, such as the acquisition strategies in Bayesian optimization. Despite significant research, current architecture generation techniques face problems such as low generation efficiency and insufficient constraints, leading to invalidly generated architectures. To this end, we propose Progressive Neural Architecture Generation (PNAG), which constructs architectures incrementally through coarse-to-fine evolution, enhancing generation efficiency, and incorporates step-wise refinements to ensure the validity of the generated architecture. To achieve this, PNGA involves two modules, multi-scale sub-architecture quantization (MSQ) and step-wise consistency constraint (SCC). Specifically, MSQ constructs sub-architectures using quantization decoding and progressively expands them, transitioning from simple to complex forms. This operation bypasses network inference to enhance efficiency.Complementing MSQ, SCC, implemented through a tailored regularization mechanism, introduces penalties for deviations during sub-architecture generation, guiding the process towards valid target architectures. As such, PNAG establishes a clear generation path, laying the groundwork for generating suitable architectures in downstream tasks. Extensive experiments demonstrate that PNAG not only generates superior architectures for various downstream tasks (+8.43%/+5.07%, on average) but also significantly improves generation efficiency, reducing the architecture generation time by 1300x. Furthermore, PNAG demonstrates strong extensibility by successfully generating Transformer-based architectures.

Jiaqi Han, Juntong Shi, Puheng Li, Haotian Ye, Qiushan Guo, Stefano Ermon

Diffusion models have become the dominant tool for high-fidelity image and video generation, yet are critically bottlenecked by their inference speed due to the numerous iterative passes of Diffusion Transformers. To reduce the exhaustive compute, recent works resort to the feature caching and reusing scheme that skips network evaluations at selected diffusion steps by using cached features in previous steps. However, their preliminary design solely relies on local approximation, causing errors to grow rapidly with large skips and leading to degraded sample quality at high speedups. In this work, we propose spectral diffusion feature forecaster (Spectrum), a training-free approach that enables global, long-range feature reuse with tightly controlled error. In particular, we view the latent features of the denoiser as functions over time and approximate them with Chebyshev polynomials. Specifically, we fit the coefficient for each basis via ridge regression, which is then leveraged to forecast features at multiple future diffusion steps. We theoretically reveal that our approach admits more favorable long-horizon behavior and yields an error bound that does not compound with the step size. Extensive experiments on various state-of-the-art image and video diffusion models consistently verify the superiority of our approach. Notably, we achieve up to 4.79x speedup on FLUX.1 and 4.67x speedup on Wan2.1-14B, while maintaining much higher sample quality compared with the baselines.

Yanning Hou, Peiyuan Li, Zirui Liu, Yitong Wang, Yanran Ruan, Jianfeng Qiu, Ke Xu

Zero-shot anomaly detection (ZSAD) requires detecting and localizing anomalies without access to target-class anomaly samples. Mainstream methods rely on vision-language models (VLMs) such as CLIP: they build hand-crafted or learned prompt sets for normal and abnormal semantics, then compute image-text similarities for open-set discrimination. While effective, this paradigm depends on a text encoder and cross-modal alignment, which can lead to training instability and parameter redundancy. This work revisits the necessity of the text branch in ZSAD and presents VisualAD, a purely visual framework built on Vision Transformers. We introduce two learnable tokens within a frozen backbone to directly encode normality and abnormality. Through multi-layer self-attention, these tokens interact with patch tokens, gradually acquiring high-level notions of normality and anomaly while guiding patches to highlight anomaly-related cues. Additionally, we incorporate a Spatial-Aware Cross-Attention (SCA) module and a lightweight Self-Alignment Function (SAF): SCA injects fine-grained spatial information into the tokens, and SAF recalibrates patch features before anomaly scoring. VisualAD achieves state-of-the-art performance on 13 zero-shot anomaly detection benchmarks spanning industrial and medical domains, and adapts seamlessly to pretrained vision backbones such as the CLIP image encoder and DINOv2. Our code is publicly available at https://github.com/7HHHHH/VisualAD.

Jing Hao, Yuci Liang, Lizhuo Lin, Yuxuan Fan, Wenkai Zhou, Kaixin Guo, Zanting Ye, Yanpeng Sun, Xinyu Zhang, Yanqi Yang 等

Multimodal Large Language Models (MLLMs) have exhibited immense potential across numerous medical specialties, yet dentistry remains underexplored, in part due to limited domain-specific data, scarce dental expert annotations, insufficient modality-specific modeling, and challenges in reliability. In this paper, we present OralGPT-Omni, the first dental-specialized MLLM designed for comprehensive and trustworthy analysis across diverse dental imaging modalities and clinical tasks. To explicitly capture dentists' diagnostic reasoning, we construct TRACE-CoT, a clinically grounded chain-of-thought dataset that mirrors dental radiologists' decision-making processes. This reasoning supervision, combined with our proposed four-stage training paradigm, substantially strengthens the model's capacity for dental image understanding and analysis. In parallel, we introduce MMOral-Uni, the first unified multimodal benchmark for dental image analysis. It comprises 2,809 open-ended question-answer pairs spanning five modalities and five tasks, offering a comprehensive evaluation suite to date for MLLMs in digital dentistry. OralGPT-Omni achieves an overall score of 51.84 on the MMOral-Uni benchmark and 45.31 on the MMOral-OPG benchmark, dramatically outperforming the scores of GPT-5. Our work promotes intelligent dentistry and paves the way for future advances in dental image analysis. All code, benchmark, and models will be made publicly available.

Junkai Lin, Hang Long, Huipeng Guo, Jielei Zhang, Jiayi Yang, Tianle Guo, Yang Yang, Jianwen Li, Wenxiao ZHANG, Matthias Nießner 等

Meshes serve as a primary representation for 3D assets. Autoregressive mesh generators serialize faces into sequences and train on truncated segments with sliding-window inference to cope with memory limits. However, this mismatch breaks long-range geometric dependencies, producing holes and fragmented components. To address this critical limitation, we introduce MeshRipple, which expands a mesh outward from an active generation frontier, akin to a ripple on a surface. MeshRipple rests on three key innovations: a frontier-aware BFS tokenization that aligns the generation order with surface topology; an expansive prediction strategy that maintains coherent, connected surface growth; and a sparse-attention global memory that provides an effectively unbounded receptive field to resolve long-range topological dependencies. This integrated design enables MeshRipple to generate meshes with high surface fidelity and topological completeness, outperforming strong recent baselines.

Tianci Luo, Haohao Pan, Jinpeng Wang, Niu Lian, Xinrui Chen, Bin Chen, Shu-Tao Xia, Chun Yuan

Visual in-context learning (VICL) enables visual foundation models to handle multiple tasks by steering them with demonstrative prompts. The choice of such prompts largely influences VICL performance, standing out as a key challenge. Prior work has made substantial progress on prompt retrieval and reranking strategies, but mainly focuses on prompt images while overlooking labels. We reveal these approaches sometimes get visually similar but label-inconsistent prompts, which potentially degrade VICL performance. On the other hand, higher label consistency between query and prompts preferably indicates stronger VICL results. Motivated by these findings, we develop a framework named LaPR (Label-aware Prompt Retrieval), which highlights the role of labels in prompt selection. Our framework first designs an image-label joint representation for prompts to incorporate label cues explicitly. Besides, to handle unavailable query labels at test time, we introduce a mixture-of-expert mechanism to the dual encoders with query-adaptive routing. Each expert is expected to capture a specific label mode, while the router infers query-adaptive mixture weights and helps to learn label-aware representation. We carefully design alternative optimization for experts and router, with a VICL performance-guided contrastive loss and a label-guided contrastive loss, respectively. Extensive experiments show promising and consistent improvement of LaPR on in-context segmentation, detection, and colorization tasks. Moreover, LaPR generalizes well across feature extractors and cross-fold scenarios, suggesting the importance of label utilization in prompt retrieval for VICL. Code is available at https://github.com/luotc-why/CVPR26-LaPR.

Haoqing Wu, Alexa Nawotki, Jochen Garcke

Point clouds are a fundamental 3D representation in computer vision, enabling a wide range of perception tasks. However, real-world point clouds often suffer from degradations such as incompleteness, noise, outliers, and irregular density, caused by sensor limitations or occlusions. Recovering clean and detailed shapes from such degraded data is crucial for downstream applications. While existing learning-based methods achieve progress on individual tasks like completion or denoising, they typically rely on global bottleneck features, which lose fine-grained geometry and remain sensitive to varying input quality. We propose a unified 3D restoration network that directly takes point clouds as input and adaptively reconstructs high-quality geometry under diverse degradation scenarios. At the core of our approach is a Pseudo-Query module, implemented within a Transformer backbone, which reformulates geometric translation into two cooperative stages to enhance structural clarity, robustness, and local detail preservation. Extensive experiments on curated benchmarks demonstrate that our approach surpasses state-of-the-art performance in general 3D restoration. It effectively handles complex combinations of completion, deformation, and denoising degradations. With this work, we provide a novel unified, point-only backbone for robust 3D restoration, enabling more versatile 3D perception.

Kun Yuan, Min Sun, Zhen Chen, Alejandro Lozano, Xiangteng He, Shi Li, Nassir Navab, Xiaoxiao Sun, Nicolas Padoy, Serena Yeung-Levy

There is growing interest in biomedical vision--language models trained on scientific literature. However, most pipelines compress rich multi-panel figures and long captions into coarse figure-level pairs, discarding the fine-grained correspondences clinicians rely on when zooming into local structures. We introduce Panel2Patch, a data pipeline that mines hierarchical structure from multi-panel, marker-heavy biomedical figures and their surrounding text, and converts them into multi-granular supervision. Given figures and captions, Panel2Patch parses layouts, panels, and visual markers, then constructs aligned image--text pairs at the figure, panel, and region levels, preserving local semantics instead of treating each figure as a single sample. Built on this corpus, we develop a granularity-aware pretraining strategy that unifies heterogeneous objectives from coarse didactic descriptions to fine region-focused phrases in a shared embedding space. Applying Panel2Patch to a small subset of literature figures yields substantially better performance than prior pipelines, demonstrating that exploiting hierarchical figure structure can provide more effective supervision with less pretraining data.

Shaolin Wang, Yuying Li, Lei Zhong, Shigang Li, Jianfeng Li

Omnidirectional image super-resolution (ODISR) remains challenging due to extreme magnification factors (e.g., 8x, 16x) and projection-specific distortions, which degrade edge integrity and limit model performance. This paper proposes an edge-focused framework combined with spherical geometric augmentation to address these issues. Our approach includes an Edge Focused Block (EFB) that integrates spatial-channel attention via Edge Enhanced and Refined Blocks, strengthening edge feature capture and optimization. We also design an Edge-Aware Multi-Scale (EAM) pipeline, leveraging shallow convolutions for initial feature extraction, local modules for deep mining, and a Global Integration Block for multi-scale aggregation, ensuring coherent edge reconstruction in distorted regions. To mitigate data scarcity, we introduce a rotation-translation augmentation strategy based on spherical projections, expanding datasets while preserving scene continuity. Extensive experiments show our method outperforms state-of-the-art approaches on public datasets.

Yiyi Cai, Yuhan Wu, Kunhang Li, You Zhou, Bo Zheng, Haiyang Liu

We present FloodDiffusion, a new framework for text-driven, streaming human motion generation. Given time-varying text prompts, FloodDiffusion generates text-aligned, seamless motion sequences with real-time latency.Unlike existing methods that rely on chunk-by-chunk or auto-regressive model with diffusion head, we adopt a diffusion forcing framework to model this time-series generation task under time-varying control events.We find that a straightforward implementation of vanilla diffusion forcing (as proposed for video models) fails to model real motion distributions. We demonstrate that to guarantee modeling the output distribution, the vanilla diffusion forcing must be tailored to: (i) train with a bi-directional attention instead of casual attention; (ii) implement a lower triangular time scheduler instead of a random one; (iii) utilize a continues time-varying way to introduce text conditioning.With these improvements, we demonstrate in the first time that the diffusion forcing-based framework achieves state-of-the-art performance on the streaming motion generation task, reaching an FID of 0.057 on the HumanML3D benchmark. Models, code, and weights are available.

Wenhui Tan, Xiaoyi Yu, Jiaze Li, Yijing Chen, Jianzhong Ju, Zhenbo Luo, Ruihua Song, Jian Luan

Efficiently understanding long-form videos remains a fundamental challenge for Multimodal Large Language Models (MLLMs). In this paper, we present MLLM-Sampler Joint Evolution (MSJoE), a novel framework that jointly evolves the MLLM and a lightweight key-frame sampler for efficient long-form video understanding. MSJoE builds upon a key assumption that only a small subset of key-frames is truly informative for answering each question to a video. Specifically, MSJoE first reasons out several queries, which describe diverse visual perspectives relevant to the question. Then, these queries interact with a frozen CLIP model to produce a query-frame similarity matrix. Finally, A lightweight sampler predicts key-frame sampling weights from this matrix, selecting informative frames, which are then fed into the MLLM for answer generation. Both the MLLM and sampler are jointly optimized through reinforcement learning, enabling co-adaptation of query-reasoning, frame-sampling, and key-frame understanding. A new long-video QA dataset containing 2.8k videos with 7k question-answer pairs is collected to support the training process. Extensive experiments on VideoMME, LongVideoBench, LVBench, and MLVU show that MSJoE achieves 8.0% accuracy gain upon the base MLLM, and 1.1% higher accuracy than strongest baseline method.

Shuhao Kang, Youqi Liao, Peijie Wang, Wenlong Liao, Qilin Zhang, Benjamin Busam, Xieyuanli Chen, Yun Liu

Text-to-point-cloud (T2P) localization aims to infer precise spatial positions within 3D point cloud maps from natural language descriptions, reflecting how humans perceive and communicate spatial layouts through language. However, existing methods largely rely on shallow text-point cloud correspondence without effective spatial reasoning, limiting their accuracy in complex environments. To address this limitation, we propose VLM-Loc, a framework that leverages the spatial reasoning capability of large vision-language models (VLMs) for T2P localization. Specifically, we transform point clouds into bird's-eye-view (BEV) images and scene graphs that jointly encode geometric and semantic context, providing structured inputs for the VLM to learn cross-modal representations bridging linguistic and spatial semantics. On top of these representations, we introduce a partial node assignment mechanism that explicitly associates textual cues with scene graph nodes, enabling interpretable spatial reasoning for accurate localization. To facilitate systematic evaluation across diverse scenes, we present CityLoc, a benchmark built from multi-source point clouds for fine-grained T2P localization. Experiments on CityLoc demonstrate VLM-Loc achieves superior accuracy and robustness compared to state-of-the-art methods. Our code, model, and dataset are available at \href https://github.com/MCG-NKU/nku-3d-vision repository .