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Budhitama Subagdja, Shanthoshigaa D, Ah-Hwee Tan, Iris Rawtaer

This paper introduces a novel system for in-home cognitive health assessment using ambient sensors and a machine learning technology that can robustly detect mild cognitive impairment (MCI) despite limited available data. The learned model can explain the aspects of individuals' daily lives led to the prediction, while reliably predicting MCI, providing more insights to healthcare workers for further clinical interventions. We developed the robust transparent machine learning model, based on fusion adaptive resonance theory (Fusion ART) neural network to learn individuals' daily patterns of activity from continuous sensor data in terms of a suite of digital biomarkers reflecting four key domains: physical, daily activity, cognitive engagement, and sleep patterns. Based on a longitudinal study of over one hundred participants, deployed with non-intrusive sensors in their homes to undergo parallel clinical evaluation across a period of five years, our model successfully identified individuals with MCI, achieving high predictive accuracy regardless the noisy and sparse availability of data. As a transparent neural network, the learned model can also be interpreted as classification rules to distinguish MCI from normal cognition (NC) cases based on the digital biomarkers. These results demonstrate that passively collected, sensor-derived digital biomarkers can be leveraged to indicate cognitive status and potentially providing clinically meaningful insights on the impairment conditions. We also discuss the practical challenges and lessons learned from this real-world deployment to inform future large-scale implementations of such AI-driven health monitoring systems.

Chathurangi Shyalika, Aryaman Sharma, Fadi El Kalach, Utkarshani Jaimini, Cory Henson, Ramy Harik, Amit Sheth

Modern manufacturing environments demand not only accurate predictions but also interpretable insights to process anomalies, root causes, and potential interventions. Existing AI systems often function as isolated black boxes, lacking the seamless integration of prediction, explanation, and causal reasoning required for a unified decision-support solution. This fragmentation limits their trustworthiness and practical utility in high-stakes industrial environments. In this work, we present CausalTrace, a neurosymbolic causal analysis module integrated into the SmartPilot industrial CoPilot. CausalTrace performs data-driven causal analysis enriched by industrial ontologies and knowledge graphs, including advanced functions such as causal discovery, counterfactual reasoning, and root cause analysis (RCA). It supports real-time operator interaction and is designed to complement existing agents by offering transparent, explainable decision support. We conducted a comprehensive evaluation of CausalTrace using multiple causal assessment methods and the C3AN framework (i.e. Custom, Compact, Composite AI with Neurosymbolic Integration), which spans principles of robustness, intelligence, and trustworthiness. In an academic rocket assembly testbed, CausalTrace achieved substantial agreement with domain experts (ROUGE-1: 0.91 in ontology QA) and strong RCA performance (MAP@3: 94%, PR@2: 97%, MRR: 0.92, Jaccard: 0.92). It also attained 4.59/5 in the C3AN evaluation, demonstrating precision and reliability for live deployment.

Segev Shlomov, Alon Oved, Sami Marreed, Ido Levy, Offer Akrabi, Avi Yaeli, Łukasz Strąk, Elizabeth Koumpan, Yinon Goldshtein, Eilam Shapira 等

Agents are rapidly advancing in automating digital work, but enterprises face a harder challenge: moving beyond prototypes to deployed systems that deliver measurable business value. This path is complicated by fragmented frameworks, slow development, and the absence of standardized evaluation practices. Generalist agents have emerged as a promising direction, excelling on academic benchmarks and offering flexibility across tasks, applications, and modalities. Yet, evidence of their use in enterprise settings remains limited. This paper reports IBM’s experience developing and piloting the Computer Using Generalist Agent (CUGA). CUGA adopts a hierarchical planner--executor architecture with strong analytical foundations, achieving state-of-the-art performance on AppWorld and WebArena. Beyond benchmarks, it was evaluated in a Business-Process-Outsourcing talent acquisition pilot, addressing enterprise requirements for scalability, auditability, safety, and governance. In preliminary evaluations, CUGA approached the accuracy of specialized agents while suggesting reductions in development time and cost. We provide early evidence that generalist agents can operate at enterprise scale, distill key technical and organizational lessons, and outline requirements for transitioning research-grade architectures like CUGA into enterprise-ready systems.

Benedikt Schlereth-Groh, Sakir Furkan Yöndem, Ramin Tavakoli Kolagari

Reinforcement Learning (RL) has shown significant promise in developing autonomous navigation algorithms for complex environments. However, the direct application of RL policies trained in simulation to real-world scenarios often faces challenges due to the reality gap. This paper proposes a two-stage system incorporating a segmentation strategy and a bird’s-eye-view (BEV) representation to mitigate the domain gap between simulation and reality. In the first stage, the segmentation transforms sensor data into a simplified and interpretable representation of the surrounding area, facilitating transferability across different deployments. In the second stage, the agent navigates through the BEV map, which can be trained using a vectorized simulation environment---a setup that runs multiple parallel instances of the environment to provide a wide range of training scenarios. This vectorization enables rapid exposure to varied environmental conditions, thereby accelerating and diversifying the training of a deep RL agent to achieve optimal navigation behaviors while maintaining high-speed, in-bound trajectories. The segmentation is crucial because it supports generalization of the learned policy across different robotic platforms. The contribution of this paper lies in combining real-time semantic segmentation with a bird’s-eye-view navigation policy, resulting in a transferable and scalable framework for real-world deployment of RL-based navigation agents. Experimental results demonstrate that agents trained with this methodology exhibit robust navigation performance and adaptability in both simulated and real-world environments, validating the efficacy of combining vectorized simulation with real-world segmentation for practical robotic navigation.

Uttam Rao, Madhav Marathe

Bibliometric and science-of-science studies have yielded valuable insights into co-authorship and citation networks, yet most analyses rely on static datasets and limited relation types. We introduce a multi-agent AI architecture that orchestrates specialized large language model (LLM) agents (ingestion, extraction, disambiguation, integration, and analysis) to build and query a comprehensive knowledge graph. Ingestion agents unify data from diverse sources such as OpenAlex, ORCID, ROR, USPTO, and custom web scrapers. Extraction agents harness LLMs to parse unstructured text. Disambiguation agents combine rule-based heuristics with LLM reasoning to resolve ambiguous authors and institutions. Integration agents assemble and cache a provenance-rich graph. An analysis agent translates natural language questions into graph queries and interprets results. This end-to-end pipeline produces a rich graph schema spanning authors, institutions, publications, patents, grants, topics, and temporal relations. Researcher mobility and knowledge diffusion are then modeled as timed automata, where each researcher node’s institutional transitions and accumulated attributes (such as publications, collaborators, and topic expertise) enable dynamic temporal reasoning. Results show that our multi-agent, graph-based system consistently outperforms standalone LLMs and research agents on complex temporal queries, entity disambiguation accuracy, and cross-entity reasoning while maintaining competitive efficiency. These capabilities position the system as a foundation for real-time, LLM-assisted knowledge analysis platforms that can support science policy, research evaluation, and meta-scientific inquiry.

Md Masudur Rahman, Mohamed El Masry, Gayle Gordillo, Juan Wachs

In emerging clinical applications such as ultrasound-based burn assessment, the lack of domain-specific data presents a significant challenge for developing robust AI systems. Vision-language models (VLMs) have shown strong performance in general computer vision tasks, yet their application to medical imaging remains limited, particularly due to insufficient reasoning capabilities and the scarcity of high-quality training data. We introduce AURA (Automated Unified Reasoning for Burn Assessment), a multi-modal approach that integrates pre-trained VLMs with symbolic first-order logic (FOL) reasoning to improve diagnostic accuracy and interpretability in this data-limited setting. For this study, we collected real-patient data over a one-year period at a U.S. burn center, performing all experiments in a real clinical setting to ensure practical relevance. The dataset includes both conventional B-Mode ultrasound and Tissue Doppler Imaging (TDI), with TDI introduced here for the first time in burn assessment, underscoring the emerging nature of this work. Beyond burn severity classification, we assess the system’s ability to produce expert-level surgical insight directly from imaging data. On the retrospective dataset, it achieves up to 93% accuracy in surgical classification and 87% in fine-grained burn depth prediction, comparable to expert-informed predictions and substantially exceeding the 70% accuracy of traditional visual inspection by human experts. These results, obtained from a novel multi-modal dataset collected in a real clinical burn center setting, highlight the potential of this approach to improve decision-making in burn care. To further support future deployment, we demonstrate a prototype integration with an Electronic Medical Record (EMR) system that aligns with clinical workflows and supports scalable, real-world implementation.

Abinash Pegu

Professional photography face retouching requires achieving a balance between texture preservation and quality increase, a problem that conventional automated methods find difficult to effectively handle. We provide a new lightweight neural architecture that converts conventional dodge-and-burn photography methods into predictions for learnable additive blend maps. Instead of rebuilding whole images, our method uses a small U-Net that predicts pixel-level changes, allowing for exact brightness adjustments while maintaining the original skin texture. With a 6MB model that operates effectively on common hardware, the technique produces high-quality results while preserving texture fidelity, which is crucial for professional applications. Experimental validation offers significant computing advantages while demonstrating competitive performance with current methods.

Sibendu Paul, Haotian Jiang, Caren Chen

Automatically extracting engaging and high-quality humorous scenes from cinematic titles is pivotal for creating captivating video previews and snackable content, boosting user engagement on streaming platforms. Long-form cinematic titles, with their extended duration and complex narratives, challenge scene localization, while humor’s reliance on diverse modalities and its nuanced style add further complexity. This paper introduces an end-to-end system for automatically identifying and ranking humorous scenes from long-form cinematic titles, featuring shot detection, multimodal scene localization, and humor tagging optimized for cinematic content. Key innovations include a novel scene segmentation approach combining visual and textual cues, improved shot representations via guided triplet mining, and a multimodal humor tagging framework leveraging both audio and text modalities. Our system achieves an 18.3% AP improvement over state-of-the-art scene detection on the OVSD dataset and an F1 score of 0.834 for detecting humor in long text. Extensive evaluations across five cinematic titles demonstrate 87% of clips extracted by our pipeline are intended to be funny, while 98% of scenes are accurately localized. With successful generalization to trailers, these results showcase the pipeline’s potential to enhance content creation workflows, improve user engagement, and streamline snackable content generation for diverse cinematic media formats.

Unmesh Padalkar

In daily fantasy sports (DFS), match participation is highly time-sensitive. Users must act within a narrow window before a game begins, making match recommendation a time-critical task to prevent missed engagement and revenue loss. Existing recommender systems, typically designed for static item catalogs, are ill-equipped to handle the hard temporal deadlines inherent in these live events. To address this, we designed and deployed a recommendation engine using the Deep Interest Network (DIN) architecture. We adapt the DIN architecture by injecting temporality at two levels: first, through real-time urgency features for each candidate match (e.g., time-to-round-lock), and second, via temporal positional encodings that represent the time-gap between each historical interaction and the current recommendation request, allowing the model to dynamically weigh the recency of past actions. This approach, combined with a listwise neuralNDCG loss function, produces highly relevant and urgency-aware rankings. To support this at industrial scale, we developed a multi-node, multi-GPU training architecture on Ray and PyTorch. Our system, validated on a massive industrial dataset with over 650k users and over 100B interactions, achieves a +9% lift in nDCG@1 over a heavily optimized LightGBM baseline with handcrafted features. The strong offline performance of this model establishes its viability as a core component for our planned on-device (edge) recommendation system, where online A/B testing will be conducted.

Yabo Ni, Cao Yuanpeng, Wenhang Zhou, Bangyang Hong, Zhongyi Zhang, Enlei Cai, Kangle Wu, Anxiang Zeng, Han Yu, Xiaoxiao Li

Large language models (LLMs) have shown great potential in enhancing search and recommender systems by providing rich semantic representations from unstructured texts. However, directly integrating LLM embeddings into industrial recommendation pipelines often results in subpar performance due to the semantic and distributional mismatch between pre-trained LLM features and domain-specific, feedback-driven representations. Existing approaches struggle to effectively align LLM embeddings with recommendation objectives, often facing challenges such as label misalignment or the potential loss of semantic diversity during fine-tuning. In this work, we present TreeBridge, a novel framework that introduces a structure-aware generative encoding tree to bridge the semantic gap between LLM embeddings and recommendation tasks. It preserves the external semantic richness of LLM embeddings, while learning label-informed structures that capture user preferences and interaction patterns. This enables the generation of task-adaptive representations without compromising embedding diversity. We further adopt an online-offline hybrid service paradigm to ensure low-latency real-world deployment. TreeBridge has been deployed on the Shopee e-commerce platform, one of the largest online shopping platforms in Southeast Asia serving hundreds of millions of users. Since its deployment in May 2025, it has helped the company achieve a commercially significant 1.55% relative improvement in gross merchandise volume (GMV). The deployment experience demonstrates the effectiveness, scalability, and significant commercial value of TreeBridge.

Mark Moussa, Amber V. Young, Brianna Isola, Vasuda Trehan, Michael D. Himes, Nicholas Wogan, Giada Arney

Future direct-imaging flagship missions, such as NASA's Habitable Worlds Observatory (HWO), face critical decisions in prioritizing observations due to extremely stringent time and resource constraints. In this paper, we introduce two advanced machine-learning architectures tailored for predicting biosignature species fluxes from exoplanetary reflected-light spectra: a Bayesian Convolutional Neural Network (BCNN) and our novel model architecture, the Spectral Query Adaptive Transformer (SQuAT). The BCNN robustly quantifies both epistemic and aleatoric uncertainties, offering reliable predictions under diverse observational conditions, whereas SQuAT employs query-driven attention mechanisms to enhance interpretability by explicitly associating spectral features with specific biosignature species. We demonstrate that both models achieve comparably high predictive accuracy on an augmented dataset spanning a wide range of exoplanetary conditions, while highlighting their distinct advantages in uncertainty quantification and spectral interpretability. These capabilities position our methods as promising tools for accelerating target triage, optimizing observation schedules, and maximizing scientific return for upcoming flagship missions such as HWO.

Gao Mo, Naveen Janaki Raman, Megan Chai, Cindy Peng, Shannon Pagdon, Nev Jones, Hong Shen, Margaret Swarbrick, Fei Fang

Behavioral health conditions, which include mental health and substance use disorders, are the leading disease burden in the United States. Peer-run behavioral health organizations (PROs) critically assist individuals facing these conditions by combining mental health services with assistance for needs such as income, employment, and housing. However, limited funds and staffing make it difficult for PROs to address all service user needs. To assist peer providers at PROs with their day-to-day tasks, we introduce PeerCoPilot, a large language model (LLM)-powered assistant that helps peer providers create wellness plans, construct step-by-step goals, and locate organizational resources to support these goals. PeerCoPilot ensures information reliability through a retrieval-augmented generation pipeline backed by a large database of over 1,300 vetted resources. We conducted human evaluations with 15 peer providers and 6 service users and found that over 90% of users supported using PeerCoPilot. Moreover, we demonstrate that PeerCoPilot provides more reliable and specific information than a baseline LLM. PeerCoPilot is now used by a group of 5-10 peer providers at CSPNJ, a large behavioral health organization serving over 10,000 service users, and we are actively expanding PeerCoPilot's use.

Pratik Mishra, Caner Gözübüyük, Seema Nagar, Prateeti Mohapatra, Raya Wittich, Arthur De Magalhaes

Manual creation of IT monitoring dashboard widgets is slow, error-prone, and a barrier for both novice and expert users. We present NOVAID, an interactive chatbot that leverages Large Language Models (LLMs) to generate IT monitoring widgets directly from natural language queries. Unlike general natural language–to-visualization tools, NOVAID addresses IT operations–specific challenges: specialized widget types like SLO charts, dynamic API-driven data retrieval, and complex contextual filters. The system combines a domain-aware semantic parser, fuzzy entity matching, and schema completion to produce standardized widget JSON specifications. An interactive clarification loop ensures accuracy in underspecified queries. On a curated dataset of 271 realistic queries, NOVAID achieves promising accuracy (up to 94.10% in metric extraction) across multiple LLMs. A user study with IT engineers yielded a System Usability Scale score of 74.2 for NOVAID, indicating good usability. By bridging natural language intent with operational dashboards, NOVAID demonstrates clear potential and a path for deployment in enterprise ITOps monitoring platforms.

Thomas Manzini, Priyankari Perali, Robin R. Murphy

This paper presents the first AI/ML system for automating building damage assessment in uncrewed aerial systems (sUAS) imagery to be deployed operationally during federally declared disasters (Hurricanes Debby and Helene). In response to major disasters, sUAS teams are dispatched to collect imagery of the affected areas to assess damage; however, at recent disasters, teams collectively delivered between 47GB and 369GB of imagery per day, representing more imagery than can reasonably be transmitted or interpreted by subject matter experts in the disaster scene, thus delaying response efforts. To alleviate this data avalanche encountered in practice, computer vision and machine learning techniques are necessary. While prior work has been deployed to automatically assess damage in satellite imagery, there is no current state of practice for sUAS-based damage assessment systems, as all known work has been confined to academic settings. This work establishes the state of practice via the development and deployment of models for building damage assessment with sUAS imagery. The model development involved training on the largest known dataset of post-disaster sUAS aerial imagery, containing 21,716 building damage labels, and the operational training of 91 disaster practitioners. The best performing model was deployed during the responses to Hurricanes Debby and Helene, where it assessed a combined 415 buildings in approximately 18 minutes. This work contributes documentation of the actual use of AI/ML for damage assessment during a disaster and lessons learned to the benefit of the AI/ML research and user communities.

Frederik Rajiv Manichand, Robin Deuber, Robert Jakob, Steve Swerling, Jamie Rosen, Elgar Fleisch, Patrick Langer

Estimating Body Mass Index (BMI) from camera images with machine learning models enables rapid weight assessment when traditional methods are unavailable or impractical, such as in telehealth or emergency scenarios. Existing computer vision approaches have been limited to datasets of up to 14,500 images. In this study, we present a deep learning-based BMI estimation method trained on our WayBED dataset, a large proprietary collection of 84,963 smartphone images from 25,353 individuals. We introduce an automatic filtering method that uses posture clustering and person detection to curate the dataset by removing low-quality images, such as those with atypical postures or incomplete views. This process retained 71,322 high-quality images suitable for training. We achieve a Mean Absolute Percentage Error (MAPE) of 7.9% on our hold-out test set (WayBED data) using full-body images, the lowest value in the published literature to the best of our knowledge. Further, we achieve a MAPE of 13% on the completely unseen (during training) VisualBodyToBMI dataset, comparable with state-of-the-art approaches trained on it, demonstrating robust generalization. Lastly, we fine-tune our model on VisualBodyToBMI and achieve a MAPE of 8.56%, the lowest reported value on this dataset so far. We deploy the full pipeline, including image filtering and BMI estimation, on Android devices using the CLAID framework. We release our complete code for model training, filtering, and the CLAID package for mobile deployment as open-source contributions.

Sel Ly, Rufan Yang, Ninad Dixit, Hung Dinh Nguyen

Lithium-ion (Li-ion) batteries are the major type of battery used in a variety of everyday applications, including electric vehicles (EVs), mobile devices, and energy storage systems. Predicting the Remaining Useful Life (RUL) of Li-ion batteries is crucial for ensuring their reliability, safety, and cost-effectiveness in battery-powered systems. The materials used for the battery cathodes and their designs play a significant role in determining the degradation rates and RUL, as they lead to distinct electrochemical reactions. Unfortunately, RUL prediction models often overlook the cathode materials and designs to simplify the model-building process, ignoring the effects of these electrochemical reactions. Other reasons are that specifications related to battery materials may not always be readily available, and a battery might consist of a mix of different materials. As a result, the predictive models that are developed often lack generalizability. To tackle these challenges, this paper proposes a novel material-based Mixture-of-Experts (MoE) approach for predicting the RUL of batteries, specifically addressing the complexities associated with heterogeneous battery chemistries. The MoE is integrated into a probabilistic framework, called Multiple Non-crossing Quantile Mixture-of-Experts for Probabilistic Prediction (RUL-QMoE), which accommodates battery operational conditions and enables uncertainty quantification. The RUL-QMoE model integrates specialized expert networks for five battery types: LFP, NCA, NMC, LCO, and NMC-LCO, within a gating mechanism that dynamically assigns relevance based on the battery's input features. Furthermore, by leveraging non-crossing quantile regression, the proposed RUL-QMoE produces coherent and interpretable predictive distributions of the battery's RUL, enabling robust uncertainty quantification in the battery's RUL prediction. Trained on seven real-world datasets, the proposed RUL-QMoE achieves strong predictive performance across all battery types, with MAE = 65 (cycles), MAPE = 9.59%, RMSE = 100 (cycles), and R2=96.84%. Compared to traditional models like XGBoost, Random Forest, CNN, and LSTM, the proposed RUL-QMoE model consistently delivers lower RMSE and superior probabilistic insights, including survival probabilities and prediction intervals. The model has been integrated into our Battery AI platform in collaboration with Toyota Motor Engineering & Manufacturing North America, Inc., as part of a broader Battery Foundation Model initiative. This RUL-QMoE model will serve future Toyota EVs' users and battery system designers.

Wenjie Lin, Jin Wei-Kocsis

While large language models (LLMs) have shown promise in healthcare, their application for rare medical conditions is still hindered by scarce and unreliable datasets for fine-tuning. Hyperhidrosis, a disorder causing excessive sweating beyond physiological needs, is one such rare disorder, affecting 2-3% of the population and significantly impacting both physical comfort and psychosocial well-being. To date, no work has tailored LLMs to advance the diagnosis or care of hyperhidrosis. To address this gap, we present LLM4Sweat, an open-source and domain-specific LLM framework for trustworthy and empathetic hyperhidrosis support. The system follows a three-stage pipeline. In the data augmentation stage, a frontier LLM generates medically plausible synthetic vignettes from curated open-source data to create a diverse and balanced question–answer dataset. In the fine-tuning stage, an open-source foundation model is fine-tuned on the dataset to provide diagnosis, personalized treatment recommendations, and empathetic psychological support. In the inference and expert evaluation stage, clinical and psychological specialists assess accuracy, appropriateness, and empathy, with validated responses iteratively enriching the dataset. Experiments show that LLM4Sweat outperforms baselines and delivers the first open-source LLM framework for hyperhidrosis, offering a generalizable approach for other rare diseases with similar data and trustworthiness challenges.

Youngkyu Lee, Jinho Lee, Youngdae Jo, Jeongwoo Park

Timely detection of retinal diseases is crucial for preventing vision loss; yet the limited availability of ophthalmologists and disparities in access to diagnostic services continue to hinder widespread screening, particularly in primary care settings. We present REMEDIS, a Software-as-a-Service (SaaS)-based clinical AI framework for the automated diagnosis of major retinal diseases, including age-related macular degeneration (AMD), diabetic retinopathy (DR), epiretinal membrane (ERM), and glaucoma, using fundus images. The system analyzes high-resolution fundus photographs in a secure cloud environment via a Swin-Large-based multi-disease classification network, producing disease-specific probability scores. To ensure clinically meaningful decision making, Youden’s Index is applied to determine optimized sensitivity-specificity thresholds for each condition. An explainability module based on Grad-CAM generates lesion localization contour visualizations, providing interpretable evidence that assists ophthalmologists in case review and facilitates integration into electronic medical records (EMR). The framework was evaluated in an IRB-approved multicenter prospective clinical trial conducted under real-world conditions, achieving an average AUC exceeding 0.94 across the four target diseases and demonstrating strong concordance with expert diagnoses. To our knowledge, this represents one of the first SaaS-based AI diagnostic frameworks for retinal diseases validated through prospective clinical studies, highlighting its potential as an emerging clinical application of AI.

Valerio La Gatta, Marco Postiglione, Jeremy Gilbert, Daniel W. Linna Jr., Morgan Manella Greenfield, Aaron Shaw, VS Subrahmanian

Numerous social movements (SMs) around the world help support the UN's Sustainable Development Goals (SDGs). Understanding how key events shape SMs is key to the achievement of the SDGs. We have developed SMART (Social Media Analysis & Reasoning Tool) to track social movements related to the SDGs. SMART was designed by a multidisciplinary team of AI researchers, journalists, communications scholars and legal experts. This paper describes SMART's transformer-based multivariate time series Discourse Evolution Engine for Predictions about Social Movements (DEEP) to predict the volume of future articles/posts and the emotions expressed. DEEP outputs probabilistic forecasts with uncertainty estimates, providing critical support for editorial planning and strategic decision-making. We evaluate DEEP with a case study of the #MeToo movement by creating a novel longitudinal dataset (433K Reddit posts and 121K news articles) from September 2024 to June 2025, which is publicly available for research purposes.

Tarun Kumar, Aalap Tripathy, Gayathri Saranathan, Martin Foltin, Suparna Bhattacharya, Scott Hinchley, Donald M Bahls, David Brookshire, Larry Kaplan, Robert W. Wisniewski

The proliferation of Model Context Protocol (MCP) servers in enterprise infrastructure management has revolutionized AI-driven automation while introducing critical multi-layered security vulnerabilities that traditional cybersecurity frameworks cannot adequately address. This paper presents a comprehensive intelligent guardrail system that addresses the unique security challenges of MCP-driven infrastructure management through a novel four-layer defense architecture. Our solution employs a dedicated guardian LLM that interprets natural language policies and applies contextual reasoning to complex infrastructure scenarios, providing dynamic policy enforcement that adapts to user roles, operational timing, and system context. Unlike existing rule-based security systems, our approach implements guardrails at four distinct control points: input message filtering, tool selection validation, execution-time verification, and post-action auditing. The system addresses critical gaps in existing security solutions by providing infrastructure-specific threat modeling, real-time policy adaptation, and comprehensive audit trails with explainable decision-making through confidence scores and detailed reasoning. Our evaluation demonstrates the system's effectiveness in preventing command injection, privilege escalation, and tool poisoning attacks across various enterprise infrastructure scenarios while maintaining operational agility essential for modern data center management.