Deep Neural Networks (DNNs), as valuable intellectual property, face unauthorized use. Existing protections, such as digital watermarking, are largely passive; they provide only post-hoc ownership verification and cannot actively prevent the illicit use of a stolen model. This work proposes a proactive protection scheme, dubbed ``Authority Backdoor," which embeds access constraints directly into the model. In particular, the scheme utilizes a backdoor learning framework to intrinsically lock a model's utility, such that it performs normally only in the presence of a specific trigger (e.g., a hardware fingerprint). But in its absence, the DNN's performance degrades to be useless. To further enhance the security of the proposed authority scheme, the certifiable robustness is integrated to prevent an adaptive attacker from removing the implanted backdoor. The resulting framework establishes a secure authority mechanism for DNNs, combining access control with certifiable robustness against adversarial attacks. Extensive experiments on diverse architectures and datasets validate the effectiveness and certifiable robustness of the proposed framework.
论文检索
输入标题、作者或关键词，从 11,272 篇学术成果中精准定位
An LLM-based Quantitative Framework for Evaluating High-Stealthy Backdoor Risks in OSS Supply Chains
PDF ↗In modern software development workflows, the open-source software supply chain significantly contributes to efficient and convenient engineering practices. With increasing system complexity, it has become a common practice to use open-source software as third-party dependencies. However, due to the lack of maintenance for underlying dependencies and insufficient community auditing, ensuring the security of source code and the legitimacy of repository maintainers has become a challenge, particularly in the context of high-stealth backdoor attacks such as the XZ-Util incident. To address these problems, we propose a fine-grained project evaluation framework for backdoor risk assessment in open-source software. Our evaluation framework models highly stealthy backdoor attacks from the attacker’s perspective and defines targeted metrics for each attack stage. Moreover, to overcome the limitations of static analysis in assessing the reliability of repository maintenance activities, such as irregular committer privilege escalation and insufficient review participation, we employ large language models (LLMs) to perform semantic evaluation of code repositories while avoiding reliance on manually crafted patterns. The effectiveness of our framework is validated on 66 high-priority packages in the Debian ecosystem, and the experimental results reveal that the current open-source software supply chain is exposed to a series of security risks.
Advanced Persistent Threats (APTs) are difficult to detect due to their complexity and stealthiness. To mitigate such attacks, many approaches model entities and their relationship using provenance graphs to detect the stealthy and persistent characteristics of APTs. However, existing detection methods suffer from the flaws of missing indirect dependencies, noisy complex scenarios, and missing behavioral logical associations, which make it difficult to detect complex scenarios and effectively identify stealthy threats. In this paper, we propose Sentient, an APT detection method that combines pre-training and intent analysis. It employs a graph transformer to learn structural and semantic information from provenance graphs to avoid missing indirect dependencies. We mitigate scenario noise by combining global and local information. Additionally, we design an Intent Analysis Module (IAM) to associate logical relationships between behaviors. Sentient is trained solely on easily obtainable benign data to detect malicious behaviors that deviate from benign behavioral patterns. We evaluated Sentient on three widely-used datasets covering real-world attacks and simulated attacks. Notably, compared to six state-of-the-art methods, Sentient achieved an average reduction of 44% in false positive rate(FPR) for detection.
GenePheno: Interpretable Gene Knockout-Induced Phenotype Abnormality Prediction from Gene Sequences
PDF ↗Exploring how genetic sequences shape phenotypes is a fundamental challenge in biology and a key step toward scalable, hypothesis-driven experimentation. The task is complicated by the large modality gap between sequences and phenotypes, as well as the pleiotropic nature of gene–phenotype relationships. Existing sequence-based efforts focus on the degree to which variants of specific genes alter a limited set of phenotypes, while general gene knockout-induced phenotype abnormality prediction methods heavily rely on curated genetic information as inputs, which limits scalability and generalizability. As a result, the task of broadly predicting the presence of multiple phenotype abnormalities under gene knockout directly from gene sequences remains underexplored. We introduce GenePheno, the first interpretable multi-label prediction framework that predicts knockout-induced phenotypic abnormalities from gene sequences. GenePheno employs a contrastive multi-label learning objective that captures inter-phenotype correlations, complemented by an exclusive regularization that enforces biological consistency. It further incorporates a gene function bottleneck layer, offering human-interpretable concepts that reflect functional mechanisms behind phenotype formation. To support progress in this area, we curate four datasets with canonical gene sequences as input and multi-label phenotypic abnormalities induced by gene knockouts as targets. Across these datasets, GenePheno achieves state-of-the-art gene-centric Fmax and phenotype-centric AUC, and case studies demonstrate its ability to reveal gene functional mechanisms.
Intelligent agents powered by large language models (LLMs) have recently demonstrated impressive capabilities and gained increasing popularity on social media platforms. While LLM agents are reshaping the ecology of social media, there exists a current gap in conducting a comprehensive evaluation of their ability to comprehend media content, understand user behaviors, and make intricate decisions. To address this challenge, we introduce SoMe, a pioneering benchmark designed to evaluate social media agents equipped with various agent tools for accessing and analyzing social media data. SoMe comprises a diverse collection of 8 social media agent tasks, 9,164,284 posts, 6,591 user profiles, and 25,686 reports from various social media platforms and external websites, with 17,869 meticulously annotated task queries. Compared with the existing datasets and benchmarks for social media tasks, SoMe is the first to provide a versatile and realistic platform for LLM-based social media agents to handle diverse social media tasks. By extensive quantitative and qualitative analysis, we provide the first overview insight into the performance of mainstream agentic LLMs in realistic social media environments and identify several limitations. Our evaluation reveals that both the current closed-source and open-source LLMs cannot handle social media agent tasks satisfactorily. SoMe provides a challenging yet meaningful testbed for future social media agents.
Learning to Curate Context: Jointly Optimizing Retrieval and Prediction for Multimodal Social Media Popularity
PDF ↗Predicting the popularity of user-generated content (UGC) is a crucial but challenging task in social media analysis. While existing retrieval-augmented models enhance predictions by supplying rich contextual information, they remain limited by a fundamental precision-recall dilemma: enlarging the retrieval set increases coverage but introduces noisy, irrelevant context that harms prediction. In this work, we propose a unified framework that learns to retrieve, filter, and predict. Central to our approach is a Mixture-of-Logits-based retrieval module that replaces static similarity metrics with a dynamic, multi-faceted scoring function, enabling the retriever to be directly optimized by the prediction objective. Then an uncertainty-aware filter is designed to perform differentiable subset selection and refine the selected representations using the information bottleneck principle. At last, to enhance predictive robustness, we introduce a confidence-weighted test-time perturbation strategy. By learning to retrieve UGCs that are beneficial for prediction and filtering out uncertainty, our framework provides more relevant and reliable context. Extensive experiments demonstrate that the proposed framework achieves state-of-the-art performance, consistently outperforming strong baselines.
GeoGen: A Two-stage Coarse-to-Fine Framework for Fine-grained Synthetic Location-based Social Network Trajectory Generation
PDF ↗Location-Based Social Network (LBSN) check-in trajectory data are important for many practical applications like POI recommendation, advertising, and pandemic intervention. However, the high collection costs and ever-increasing privacy concerns prevent us from accessing large-scale LBSN trajectory data. The recent advances in synthetic data generation provide us with a new opportunity to achieve this, which utilizes generative AI to generate synthetic data that preserves the characteristics of real data while ensuring privacy protection. However, generating synthetic LBSN check-in trajectories remains challenging due to their spatially discrete, temporally irregular nature and the complex spatio-temporal patterns caused by sparse activities and uncertain human mobility. To address this challenge, we propose GeoGen, a two-stage coarse-to-fine framework for large-scale LBSN check-in trajectory generation. In the first stage, we reconstruct spatially continuous, temporally regular latent movement sequences from the original LBSN check-in trajectories and then design a Sparsity-aware Spatio-temporal Diffusion model (S^2TDiff) with an efficient denosing network to learn their underlying behavioral patterns. In the second stage, we design Coarse2FineNet, a Transformer-based Seq2Seq architecture equipped with a dynamic context fusion mechanism in the encoder and a multi-task hybrid-head decoder, which generates fine-grained LBSN trajectories based on coarse-grained latent movement sequences by modeling semantic relevance and behavioral uncertainty. Extensive experiments on four real-world datasets show that GeoGen excels state-of-the-art models for both fidelity and utility evaluation, e.g., it increases over 69% and 55% in distance and radius metrics on the FS-TKY dataset.
scCluBench: Comprehensive Benchmarking of Clustering Algorithms for Single-Cell RNA Sequencing
PDF ↗Cell clustering is crucial for uncovering cellular heterogeneity in single-cell RNA sequencing (scRNA-seq) data by identifying cell types and marker genes. Despite its importance, existing benchmarks for scRNA-seq clustering remain fragmented, lacking standardized protocols and often omitting recent advances in artificial intelligence.To fill these gaps, we present scCluBench, a comprehensive benchmark of clustering algorithms for scRNA-seq data. scCluBench provides 36 scRNA-seq datasets collected from diverse public sources, covering multiple tissues, which are uniformly processed to ensure consistency for systematic evaluation and downstream analyses. To assess performance, we collect and reproduce a range of scRNA-seq clustering methods, including traditional, deep learning-based, graph-based, and biological foundation models. We comprehensively evaluate each method both quantitatively and qualitatively, using core performance metrics and visualization analyses. Furthermore, we construct representative downstream biological tasks, such as marker gene identification and cell type annotation, to further assess the practical utility. scCluBench then investigates the performance differences and applicability boundaries of various clustering models across diverse analytical tasks, systematically assessing their robustness and scalability in real-world scenarios. Overall, scCluBench offers a standardized and user-friendly benchmark for scRNA-seq clustering, with standardized datasets, unified evaluation protocols, and transparent analyses, facilitating informed method selection and providing valuable insights into model generalizability and application scope.
Digital circuit representation learning has made remarkable progress in electronic design automation, effectively supporting critical tasks such as testability analysis and logic reasoning. However, representation learning for analog circuits remains challenging due to their continuous electrical characteristics compared to the discrete states of digital circuits. This paper presents a direct current (DC) electrically equivalent-oriented analog representation learning framework, named KCLNet. We will open-source the dataset and code upon publication. It comprises an asynchronous graph neural network structure with electrically-simulated message passing and a representation learning method inspired by Kirchhoff's Current Law (KCL). This method maintains the orderliness of the circuit embedding space by enforcing the equality of the sum of outgoing and incoming current embeddings at each node, which significantly enhances the generalization ability of circuit embeddings. KCLNet offers a novel and effective solution for analog circuit representation learning with electrical constraints preserved. Experimental results demonstrate that our method achieves significant performance in a variety of downstream tasks, e.g., analog circuit classification, subcircuit detection, and circuit edit distance prediction.
SynWeather: Weather Observation Data Synthesis Across Multiple Regions and Variables via a General Diffusion Transformer
PDF ↗With the advancement of meteorological instruments, abundant data has become available. However, due to instruments’ intrinsic limitations such as environmental sensitivity and orbital constraints, raw data often suffer from temporal or spatial gaps, making it urgent to leverage data synthesis techniques to fill in missing information. Current approaches are typically focus on single-variable, single-region tasks and primarily rely on deterministic modeling. This limits unified synthesis across variables and regions, overlooks cross-variable complementarity and often leads to over-smoothed results. To address above challenges, we introduce SynWeather, the first dataset designed for Unified Multi-region and Multi-variable Weather Observation Data Synthesis. SynWeather covers four representative regions: the Continental United States, Europe, East Asia, and Tropical Cyclone regions, as well as provides high-resolution observations of key weather variables, including Composite Radar Reflectivity, Hourly Precipitation, Visible Light, and Microwave Brightness Temperature. In addition, we introduce SynWeatherDiff, a general and probabilistic weather synthesis model built upon the Diffusion Transformer framework to address the over-smoothed problem. Experiments on the SynWeather dataset demonstrate the effectiveness of our network compared with both task-specific and general models. Moreover, SynWeatherDiff is able to generate results that are both fine-grained and accurate in high-value regions. Through the dataset and baseline model, we aim to advance meteorological downstream tasks and promote the development of general models for weather variable synthesis.
While Large Language Models (LLMs) demonstrate immense potential for automating integrated circuit (IC) development, their practical deployment is fundamentally limited by restricted context windows. Existing context-extension methods struggle to achieve effective semantic modeling and thorough multi-hop reasoning over extensive, intricate circuit specifications. To address this, we introduce ChipMind, a novel knowledge graph-augmented reasoning framework specifically designed for lengthy IC specifications. ChipMind first transforms circuit specifications into a domain-specific knowledge graph (ChipKG) through the Circuit Semantic-Aware Knowledge Graph Construction methodology. It then leverages the ChipKG-Augmented Reasoning mechanism, combining information-theoretic adaptive retrieval to dynamically trace logical dependencies with intent-aware semantic filtering to prune irrelevant noise, effectively balancing retrieval completeness and precision. Evaluated on an industrial-scale specification reasoning benchmark, ChipMind significantly outperforms state-of-the-art baselines, achieving an average improvement of 34.59% (up to 72.73%). Our framework bridges a critical gap between academic research and practical industrial deployment of LLM-aided Hardware Design (LAD).
Diffusion Large Language Models (dLLMs) have recently emerged as a competitive non-autoregressive paradigm due to their unique training and inference approach. However, there is currently a lack of safety study on this novel architecture. In this paper, we present the first analysis of dLLMs' safety performance and propose a novel safety alignment method tailored to their unique generation characteristics. Specifically, we identify a critical asymmetry between the defender and attacker in terms of security. For the defender, we reveal that the middle tokens of the response, rather than the initial ones, are more critical to the overall safety of dLLM outputs; this seems to suggest that aligning middle tokens can be more beneficial to the defender. The attacker, on the contrary, may have limited power to manipulate middle tokens, as we find dLLMs have a strong tendency towards a sequential generation order in practice, forcing the attack to meet this distribution and diverting it from influencing the critical middle tokens. Building on this asymmetry, we introduce Middle-tOken Safety Alignment (MOSA), a novel method that directly aligns the model's middle generation with safe refusals exploiting reinforcement learning. We implement MOSA and compare its security performance against eight attack methods on two benchmarks. We also test the utility of MOSA-aligned dLLM on coding, math, and general reasoning. The results strongly prove the superiority of MOSA.
Informative Subgraph Extraction with Deep Reinforcement Learning for Drug-Drug Interaction Prediction
PDF ↗Drug-drug interaction (DDI) prediction is pivotal for drug safety and clinical decision-making. Recently, subgraph-based methods utilizing knowledge graphs (KGs) and domain information have achieved promising results by extracting informative subgraphs for DDI prediction. However, existing subgraph extraction methods are typically coarse-grained and nonspecific, facing two key limitations: First, they are constrained by the vast and noisy nature of real-world KGs, making it challenging to identify the most informative substructures from the massive space of candidate subgraphs. Second, current methods often fail to exploit the molecular structural specificity of drugs to selectively extract relevant subgraphs, lacking effective integration of molecular structure information with knowledge graph context. To address these challenges, we propose RISE-DDI, a novel framework for Reinforced-based Informative Subgraph Extraction approach for drug-drug interaction prediction. Specifically, RISE-DDI formulates the subgraph extraction as a Markov Decision Process (MDP) and leverages a deep reinforcement learning (RL) agent to dynamically and adaptively extract the most informative and context-specific subgraphs for each drug pair. The agent is guided by a learnable structure-aware reward model that considers both the topological context from the knowledge graph and the molecular features of the drug pairs, thereby encouraging the selection of subgraphs that are both structurally relevant and biologically informative. Extensive experiments on DDI benchmark datasets demonstrate that our method outperforms state-of-the-art baselines in both transductive and inductive scenarios, achieving improvements of up to 20%. Furthermore, visualization analyses of the extracted subgraphs highlight the interpretability of our model, providing insights into the underlying mechanisms of drug interactions.
GROVER: Graph-guided Representation of Omics and Vision with Expert Regulation for Adaptive Spatial Multi-omics Fusion
PDF ↗Effectively modeling multimodal spatial omics data is critical for understanding tissue complexity and underlying biological mechanisms. While spatial transcriptomics, proteomics, and epigenomics capture molecular features, they lack pathological morphological context. Integrating these omics with histopathological images is thus critical for comprehensive disease tissue analysis. However, substantial heterogeneity across omics, imaging, and spatial modalities poses significant challenges. Naive fusion of semantically distinct sources often leads to ambiguous representations. Additionally, the resolution mismatch between high-resolution histology images and lower-resolution sequencing spots complicates spatial alignment. Biological perturbations during sample preparation further distort modality-specific signals, hindering accurate integration. To address these challenges, we propose Graph-guided Representation of Omics and Vision with Expert Regulation for Adaptive Spatial Multi-omics Fusion (GROVER), a novel framework for adaptive integration of spatial multi-omics data. GROVER leverages a Graph Convolutional Network encoder based on Kolmogorov–Arnold Networks to capture the nonlinear dependencies between each modality and its associated spatial structure, thereby producing expressive, modality-specific embeddings. To align these representations, we introduce a spot-feature-pair contrastive learning strategy that explicitly optimizes the correspondence across modalities at each spot. Furthermore, we design a dynamic expert routing mechanism that adaptively selects informative modalities for each spot while suppressing noisy or low-quality inputs. Experiments on real-world spatial omics datasets demonstrate that GROVER outperforms state-of-the-art baselines, providing a robust and reliable solution for multimodal integration.
Unauthorized screen capturing and dissemination pose severe security threats such as data leakage and information theft. Several studies propose robust watermarking methods to track the copyright of Screen-Camera (SC) images, facilitating post-hoc certification against infringement. These techniques typically employ heuristic mathematical modeling or supervised neural network fitting as the noise layer, to enhance watermarking robustness against SC. However, both strategies cannot fundamentally achieve an effective approximation of SC noise. Mathematical simulation suffers from biased approximations due to the incomplete decomposition of the noise and the absence of interdependence among the noise components. Supervised networks require paired data to train the noise-fitting model, and it is difficult for the model to learn all the features of the noise. To address the above issues, we propose Simulation-to-Real (S2R). Specifically, an unsupervised noise layer employs unpaired data to learn the discrepancy between the modeled simulated noise distribution and the real-world SC noise distribution, rather than directly learning the mapping from sharp images to real-world images. Learning this transformation from simulation to reality is inherently simpler, as it primarily involves bridging the gap in noise distributions, instead of the complex task of reconstructing fine-grained image details. Extensive experimental results validate the efficacy of the proposed method, demonstrating superior watermark robustness and generalization compared to state-of-the-art methods.
Biological foundation models (BioFMs), pretrained on large-scale biological sequences, have recently shown strong potential in providing meaningful representations for diverse downstream bioinformatics tasks. However, such models often rely on millions to billions of training sequences and billions of parameters, resulting in prohibitive computational costs and significant barriers to reproducibility and accessibility—particularly for academic labs. To address these challenges, we investigate the feasibility of data pruning for BioFM pretraining and propose a post-hoc influence-guided data pruning framework tailored to biological domains. Our approach first introduces a subset-based self-influence formulation that enables efficient estimation of sample importance at low computational cost. Built upon this, we propose two simple yet effective selection strategies: Top-k Influence (Top I) and Coverage-Centric Influence (CCI). Then, we empirically validate our method on two representative BioFMs: RNA-FM and ESM-C. For RNA, our framework consistently outperforms random selection baselines under an extreme pruning rate of over 99%, which displays our framework's effectiveness. Furthermore, we demonstrate the generalizability of our framework on protein-related tasks using ESM-C. Specifically, our coreset even outperforms random 10x subsets in both RNA and protein settings, revealing substantial redundancy in biological sequence datasets. These findings underscore the potential of influence-guided data pruning to substantially reduce the computational cost of BioFM pretraining, paving the way for more efficient, accessible, and sustainable biological AI research.
Exploring Selective Avoidance for Online User Behavior Analysis: A Forest of Thought Explanation
PDF ↗The response behaviors observed in online user-generated content (UGC) frequently demonstrate non-linear characteristics, such as conditional branching and selective avoidance. These patterns present additional challenges for ensuring the trustworthiness of Large Language Model (LLMs) reasoning, particularly as their unidirectional, left-to-right inference mechanisms may not adequately capture such complex reasoning dynamics. To address this, we propose a Forest of Thought Explanation (FoTE), a novel prompting that models the selective avoidance in UGC while ensuring explanation consensus through reasoning paths across all decision sub-trees. FoTE firstly generates various reasoning paths through an adaptive CoT prompting. Each generated thought is subsequently evaluated through cooperative game theory to quantify its fair influence. The thoughts with the top-k contribution scores are preserved and randomly sampled to emulate selective avoidance for the next reasoning iteration. Through extensive evaluations across three open-source LLMs and two established social science problems (spanning four benchmark datasets), FoTE demonstrates superior success rates compared to competing prompting strategies. Notably, its performance gains increase with the strength of selective avoidance in social problems. The trustworthiness of our FoTE is enhanced by the incorporation of (1) a solid theoretical foundation and (2) a transparent reasoning path that converges toward consensus.
Generalizable Drug–Target Interaction Prediction via ESM-2 Representations and Progressive Contrastive Curriculum Learning
PDF ↗Predicting drug–target interactions (DTIs) is a fundamental task in computational drug discovery, yet it remains challenging under distribution shifts and limited training data. Existing approaches often suffer from poor generalization, weak cross-modal alignment between molecular and protein representations, and vulnerability to noisy supervision.We propose ESP-DTI, a unified framework designed to enhance generalization by integrating large-scale protein language models with curriculum learning and cross-modal contrastive alignment. Specifically, we leverage ESM-2 to encode context-aware protein representations and adopt a CLIP-style contrastive objective to align drug and protein embeddings in a shared latent space. To further improve learning robustness, we introduce a progressive curriculum sampling strategy that dynamically schedules training instances based on model confidence, enabling a gradual shift from easy to hard examples.Experimental results on four benchmark datasets demonstrate that ESP-DTI consistently outperforms state-of-the-art baselines, achieving a +3.1% improvement in average accuracy. Ablation studies confirm the complementary benefits of each component, validating their collective contribution to robust and generalizable DTI prediction.Our work underscores the effectiveness of combining pretrained protein language models with structured training curricula and cross-modal contrastive learning for reliable DTI prediction under real-world, distribution-shifted conditions.
Synergizing Multigrid Algorithms with Vision Transformer: A Novel Approach to Enhance the Seismic Foundation Model
PDF ↗Due to the rapid advancement and homogenization of Artificial Intelligence (AI) technology development, transformer-based foundation models have revolutionized scientific applications, such as drug discovery, materials research, and astronomy. However, seismic data presents unique characteristics that require specialized processing techniques for pretraining foundation models in seismic contexts with high- and low-frequency features playing crucial roles. Existing Vision Transformer (ViT) with sequential image tokenization fails to efficiently and effectively capture both high- and low-frequency seismic information because they ignore the intrinsic structural patterns of seismograms. This work introduces ADATG, a novel adaptive two-grid training strategy with Hilbert encoding, explicitly tailored for seismogram data and leveraging the hierarchical structures inherent in seismic data. Specifically, our approach employs spectrum decomposition to separate high- and low-frequency components, and hierarchical Hilbert encoding to represent the data effectively. Moreover, inspired by the frequency principle, we propose an adaptive training strategy that initially emphasizes coarse-level information and then progressively refines the model's focus on fine-level features. Extensive experiments demonstrate the effectiveness and efficiency of our method. This research highlights the importance of data encoding and training strategies informed by the distinct characteristics of high- and low-frequency features in seismic images, ultimately enhancing the pretraining of visual seismic foundation models.
Dual-Channel Learning Framework for Zero-Shot CircRNA-miRNA Interaction Prediction via State Space Modeling
PDF ↗CircRNA-miRNA interaction (CMI) plays a pivotal role in disease therapeutics and drug discovery. However, existing methods face several challenges in modeling complex biological networks and zero-shot learning scenarios. Biological networks encapsulate rich biological information, yet current approaches often fail to fully exploit this depth. Moreover, zero-shot prediction requires models to identify new interactions without relying on previously observed samples, imposing stringent requirements on generalization capabilities. To address these limitations, we propose a dual-channel learning framework leveraging State space modeling for Zero-shot CMI prediction (ZeroStem). ZeroStem first enhances the biological relevance of node using prior knowledge, and employs a graph Transformer to extract macro-topological representations. Subsequently, it generates semantic subgraphs based on meta-paths to focus on specific biological relationships, utilizing the Mamba to extract micro-semantic representations via state space modeling. Finally, macro-topological and micro-semantic representations are seamlessly integrated through linear transformation and residual connections, enabling high-precision zero-shot CMI prediction. Extensive experiments on multiple benchmark datasets demonstrate that ZeroStem significantly outperforms existing methods, validating its efficiency and robust generalization in CMI prediction. Case studies further illustrate that ZeroStem offers novel insights into the molecular mechanisms underlying intricate disease-associated networks.