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Tongshun Zhang, Pingping Liu, Zixuan Zhong, Zijian Zhang, Qiuzhan Zhou

Recovering fine-grained details in extremely dark images remains challenging due to severe structural information loss and noise corruption. Existing enhancement methods often fail to preserve intricate details and sharp edges, limiting their effectiveness in downstream applications like text and edge detection. To address these deficiencies, we propose an efficient dual-stage approach centered on detail recovery for dark images. In the first stage, we introduce a Residual Fourier-Guided Module (RFGM) that effectively restores global illumination in the frequency domain. RFGM captures inter-stage and inter-channel dependencies through residual connections, providing robust priors for high-fidelity frequency processing while mitigating error accumulation risks from unreliable priors. The second stage employs complementary Mamba modules specifically designed for textural structure refinement: (1) Patch Mamba operates on channel-concatenated non-downsampled patches, meticulously modeling pixel-level correlations to enhance fine-grained details without resolution loss. (2) Grad Mamba explicitly focuses on high-gradient regions, alleviating state decay in state space models and prioritizing reconstruction of sharp edges and boundaries. Extensive experiments on multiple benchmark datasets and downstream applications demonstrate that our method significantly improves detail recovery performance while maintaining efficiency. Crucially, the proposed modules are lightweight and can be seamlessly integrated into existing Fourier-based frameworks with minimal computational overhead.

Hui Zhang, Weikang Gao, Tao Yang, Yuan Cao

With the rapid growth of visual content in open-world environments, zero-shot hashing image retrieval (ZSHIR) has emerged to tackle the challenge of recognizing novel classes using attribute-level and semantic information. However, existing methods often rely on shallow fusion of multi-source cues (e.g., attributes, labels, and visual features) through external supervision or feature concatenation, failing to capture the underlying semantic structure in a generative way. Particularly, current bridging strategies between modalities suffer from information fragmentation and weak alignment, hindering the model's ability to fully understand complex attribute-visual relations. Moreover, subtle semantic gaps or “semantic drift” between seen and unseen classes further degrade inter-class separability and the scalability of hashing models. To address these issues, we propose a novel framework called Proxy Zero-Shot Hashing with Multimodal Fusion via Stable Diffusion (PZSH), which integrates generative modeling and contrastive learning. PZSH leverages a pre-trained Stable Diffusion (SD) model to synthesize multimodal content, and uses dual BLIP encoders to enhance semantic alignment across modalities. We further design a proxy hashing loss to enforce discriminative binary representations. Extensive experiments on benchmark datasets show that PZSH achieves state-of-the-art performance with stronger generalization to unseen classes.

Haonan Zhang, Xinyao Wang, Boxi Wu, Tu Zheng, Wang Yunhua, Zheng Yang

3D multi-object tracking is a critical and challenging task in the field of autonomous driving. A common paradigm relies on modeling individual object motion, e.g., Kalman filters, to predict trajectories. While effective in simple scenarios, this approach often struggles in crowded environments or with inaccurate detections, as it overlooks the rich geometric relationships between objects. This highlights the need to leverage spatial cues. However, existing geometry-aware methods can be susceptible to interference from irrelevant objects, leading to ambiguous features and incorrect associations. To address this, we propose focusing on cue-consistency: identifying and matching stable spatial patterns over time. We introduce the Dynamic Scene Cue-Consistency Tracker (DSC-Track) to implement this principle. Firstly, we design a unified spatiotemporal encoder using Point Pair Features (PPF) to learn discriminative trajectory embeddings while suppressing interference. Secondly, our cue-consistency transformer module explicitly aligns consistent feature representations between historical tracks and current detections. Finally, a dynamic update mechanism preserves salient spatiotemporal information for stable online tracking. Extensive experiments on the nuScenes and Waymo Open Datasets validate the effectiveness and robustness of our approach. On the nuScenes benchmark, for instance, our method achieves state-of-the-art performance, reaching 73.2% and 70.3% AMOTA on the validation and test sets, respectively.

Bofei Zhang, Zirui Shang, Zhi Gao, Wang Zhang, Rui Xie, Xiaojian Ma, Tao Yuan, Xinxiao Wu, Song-Chun Zhu, Qing Li

Building Graphical User Interface (GUI) agents is a promising research direction, which simulates human interaction with computers or mobile phones to perform diverse GUI tasks. However, a major challenge in developing generalized GUI agents is the lack of sufficient trajectory data across various operating systems and applications, mainly due to the high cost of manual annotations. In this paper, we propose the TongUI framework that transforms millions of multimodal web tutorials into GUI trajectories for generalized GUI agents. Concretely, we crawl GUI videos and articles from the Internet and process them into GUI agent trajectory data. Based on this, we construct the GUI-Net-1M dataset, which contains 1 million trajectories across five operating systems and over 280 applications. To the best of our knowledge, this is the largest open-source GUI trajectory dataset. We develop the TongUI agent by fine-tuning Qwen2.5-VL-3B/7B/32B models on GUI-Net-1M, which shows consistent performance improvements on commonly used grounding and navigation benchmarks, outperforming baseline agents by 10\% on multiple benchmarks, showing the effectiveness of the GUI-Net-1M dataset and underscoring the significance of our TongUI framework.

Zhaoquan Yuan, Zining Wang, Yuankang Pan, Ao Luo, Wei Li, Xiao Wu, Changsheng Xu

Compositional Zero-Shot Learning (CZSL) addresses the challenge of recognizing unseen attribute-object compositions in images, representing a fundamental challenge in artificial intelligence. Current approaches, which primarily focus on semantic alignment or distribution independence of primitives, have not achieved effective state-object decoupling and causal interventional invariance, limiting their performance on unseen compositions. To tackle this challenge, this study introduces I2CD (Invertible Causal framework via Disentangle-Compose-Disentangle), a novel framework that integrates invertible neural networks with causal intervention techniques to achieve state-object disentanglement. The framework employs a disentangle-compose-disentangle mechanism for counterfactual generation within the disentangled representation space, ensuring that modifications to one primitive (attribute or object) maintain independence from the other, thus enabling robust causal disentanglement. Representational consistency is maintained through semantic alignment between initial disentangled representations and their recomposed-then-disentangled counterparts with corresponding textual concepts. Comprehensive evaluations on three benchmark datasets—MIT-States, UT-Zappos, and C-GQA—demonstrate the framework's effectiveness in achieving both disentanglement and compositional generalization in CZSL tasks.

Xinxing Yu, Ajian Liu, Sunyuan Qiang, Yuzhong Wang, Hui Ma, Yanyan Liang

Point cloud tasks have recently benefited from Mamba-based architecture, which leverage state space modeling to achieve strong performance. Previous studies have primarily focused on network design while overlooking the importance of position encoding and relying on coarse-grained geometric feature aggregation. The former leads to semantic ambiguity due to inconsistent spatial relationships, while the latter results in geometric feature dispersion by overlooking fine-grained local geometric details. To tackle the above problem, we propose a novel framework, PointMC, including Multi-view Consistent Learnable Position Encoding (MCLPE) and Center-Global Feature Fusion (CGFF), to provide semantically coherent positional guidance for inter-patch and enable fine-grained geometric structure aggregation within intra-patch regions. Specifically, the proposed MCLPE module is inspired by a spatial structure modeling mechanism guided by physical constraints, leverages multi-view virtual reconstruction and a learnable strategy to dynamically constrain spatial relationships along patch boundaries, thereby enhancing the semantic consistency and representational clarity across inter-patch regions. Furthermore, considering the lack of local structural information within each patch, the CGFF module employs a dual-guidance mechanism based on center and global structures to effectively promote the aggregation of local geometric features. Extensive experiments on multiple benchmark datasets validate the effectiveness of PointMC, consistently outperforming existing state-of-the-art methods, and demonstrating superior capability in capturing both inter-patch semantic consistency and intra-patch geometric details.

Zheng Yin, Chengjian Li, Xiangbo Shu, Meiqi Cao, Rui Yan, Jinhui Tang

Comprehensively and flexibly capturing the complex spatio-temporal dependencies of human motion is critical for multi-person motion prediction. Existing methods grapple with two primary limitations: i) Inflexible spatiotemporal representation due to reliance on positional encodings for capturing spatiotemporal information. ii) High computational costs stemming from the quadratic time complexity of conventional attention mechanisms. To overcome these limitations, we propose the Spatiotemporal-Untrammelled Mixture of Experts (ST-MoE), which flexibly explores complex spatio-temporal dependencies in human motion and significantly reduces computational cost. To adaptively mine complex spatio-temporal patterns from human motion, our model incorporates four distinct types of spatiotemporal experts, each specializing in capturing different spatial or temporal dependencies. To reduce the potential computational overhead while integrating multiple experts, we introduce bidirectional spatiotemporal Mamba as experts, each sharing bidirectional temporal and spatial Mamba in distinct combinations to achieve model efficiency and parameter economy. Extensive experiments on four multi-person benchmark datasets demonstrate that our approach not only outperforms state-of-art in accuracy but also reduces model parameter by 41.38% and achieves a 3.6× speedup in training.

Kai Ye, YingShi Luan, Zhudi Chen, Guangyue Meng, Pingyang Dai, Liujuan Cao

Referring Image Segmentation (RIS), which aims to segment specific objects based on natural language descriptions, plays an essential role in vision-language understanding. Despite its progress in remote sensing applications, RIS under Low-Altitude Drone (LAD) scenarios remains underexplored, as existing datasets and methods are typically designed for high-altitude and static-view imagery. They struggled to handle the unique characteristics of LAD views, such as diverse viewpoints and high object density. In this paper, we propose RIS-LAD, the first fine-grained RIS benchmark tailored for LAD scenarios, featuring 13,871 meticulously annotated image-text-mask triplets collected from real-world drone footage with emphasis on small, densely cluttered objects and multi-view perspectives. Additionally, we propose the Semantic-Aware Adaptive Reasoning Network, which decomposes and adaptively routes semantic information to different network stages rather than uniformly injecting all linguistic features. Specifically, the Category-Dominated Linguistic Enhancement aligns visual features with object categories during early encoding, while the Adaptive Reasoning Fusion Module dynamically selects semantic cues across scales to enhance reasoning in complex scenes. Extensive experiments reveal that RIS-LAD presents substantial challenges to state-of-the-art RIS algorithms, and also demonstrate the effectiveness of our proposed model in addressing these challenges.

Yulin Yao, Kangfeng Zheng, Bin Wu, Chunhua Wu, Jujie Wang, Jiaqi Gao, Minjiao Yang, Dan Luo

Driven by advances in GANs and diffusion models, deepfake content has reached an unprecedented level of photorealism, causing detectors to deteriorate once they leave their training domain. Most prior studies adopt CLIP as the backbone of an image-level binary classifier, yet overlook CLIP’s core strength: text-to-image semantic alignment. Moreover, captions generated by CLIP-CAP lack sufficient high-level semantics to distinguish between authentic and manipulated faces. Deepfake generators often fail to maintain semantic coherence, resulting in contradictions that traditional visual models cannot capture. Existing approaches also intermingle all samples during training and thus lack a systematic, difficulty-aware curriculum. To bridge these gaps, we introduce Semantic- and Frequency-Enhanced (SAFE) deepfake detection, a two-component framework: 1) Semantic-enhanced multimodal alignment. Authenticity cues are injected into CLIP-CAP captions, and low-rank LoRA fine-tuning is applied to CLIP’s visual branch, yielding dual supervision for text–image alignment and forgery discrimination. 2) Dual-score curriculum learning. Fourier Correlation Variance (FCV) measures local spectral consistency and, combined with the loss value, is transformed into a difficulty score that ranks training samples from easy to hard, reducing training time by 23.3% and enhancing generalization. SAFE attains state-of-the-art performance on several cross-dataset and cross-manipulation benchmarks. Ablation studies confirm that semantic enhancement, LoRA fine-tuning, and dual-score curriculum are complementary, jointly delivering substantial gains in open-set generalization.

Sicheng Yang, Xing Hu, Qiang Wu, Dawei Yang

Vector quantization (VQ) transforms continuous image features into discrete representations, providing compressed, tokenized inputs for generative models. However, VQ-based frameworks suffer from several issues, such as non-smooth latent spaces, weak alignment between representations before and after quantization, and poor coherence between the continuous and discrete domains. These issues lead to unstable codeword learning and underutilized codebooks, ultimately degrading the performance of both reconstruction and downstream generation tasks. To this end, we propose VAEVQ, which comprises three key components: (1) Variational Latent Quantization (VLQ), replacing the AE with a VAE for quantization to leverage its structured and smooth latent space, thereby facilitating more effective codeword activation; (2) Representation Coherence Strategy (RCS), adaptively modulating the alignment strength between pre- and post-quantization features to enhance consistency and prevent overfitting to noise; and (3) Distribution Consistency Regularization (DCR), aligning the entire codebook distribution with the continuous latent distribution to improve utilization. Extensive experiments on two benchmark datasets demonstrate that VAEVQ outperforms state-of-the-art methods.

Muli Yang, Gabriel James Goenawan, Henan Wang, Huaiyuan Qin, Chenghao Xu, Yanhua Yang, Fen Fang, Ying Sun, Joo Hwee Lim, Hongyuan Zhu

Despite being trained on balanced datasets, existing AI-generated image detectors often exhibit systematic bias at test time, frequently misclassifying fake images as real. We hypothesize that this behavior stems from distributional shift in fake samples and implicit priors learned during training. Specifically, models tend to overfit to superficial artifacts that do not generalize well across different generation methods, leading to a misaligned decision threshold when faced with test-time distribution shift. To address this, we propose a theoretically grounded post-hoc calibration framework based on Bayesian decision theory. In particular, we introduce a learnable scalar correction to the model’s logits, optimized on a small validation set from the target distribution while keeping the backbone frozen. This parametric adjustment compensates for distributional shift in model output, realigning the decision boundary even without requiring ground-truth labels. Experiments on challenging benchmarks show that our approach significantly improves robustness without retraining, offering a lightweight and principled solution for reliable and adaptive AI-generated image detection in the open world.

Xizhe Xue, Yang Zhou, Dawei Yan, Lijie Tao, Junjie Li, Ying Li, Haokui Zhang, Rong Xiao

Recently, video-language models (VidLMs) have gained widespread attention and adoption. However, existing works primarily focus on terrestrial scenarios, overlooking the highly demanding application needs of underwater observation. To overcome this gap, we introduce UVLM, an under water observation benchmark which is build through a collaborative approach combining human expertise and AI models. To ensure data quality, we have conducted in-depth considerations from multiple perspectives. First, to address the unique challenges of underwater environments, we selected videos that represent typical underwater challenges including light variations, water turbidity, and diverse viewing angles to construct the dataset. Second, to ensure data diversity, the dataset covers a wide range of frame rates, resolutions, 419 classes of marine animals, and various static plants and terrains. Next, for task diversity, we adopted a structured design where observation targets are categorized into two major classes: biological and environmental. Each category includes content observation and change/action observation, totaling 20 subtask types. Finally, we designed several challenging evaluation metrics to enable quantitative comparison and analysis of different methods. Experiments on two representative VidLMs demonstrate that fine-tuning VidLMs on UVLM significantly improves underwater world understanding while also showing potential for slight improvements on existing in-air VidLM benchmarks.

Shuailin Xue, Jun Wan, Lihua Zhang, Wenwen Min

Accurate detection of cancer tissue regions (CTR) enables deeper analysis of the tumor microenvironment and offers crucial insights into treatment response. Traditional CTR detection methods, which typically rely on the rich cellular morphology in histology images, are susceptible to a high rate of false positives due to morphological similarities across different tissue regions. The groundbreaking advances in spatial transcriptomics (ST) provide detailed cellular phenotypes and spatial localization information, offering new opportunities for more accurate cancer region detection. However, current methods are unable to effectively integrate histology images with ST data, especially in the context of cross-sample and cross-platform/batch settings for accomplishing the CTR detection. To address this challenge, we propose SpaCRD, a transfer learning-based method that deeply integrates histology images and ST data to enable reliable CTR detection across diverse samples, platforms, and batches. Once trained on source data, SpaCRD can be readily generalized to accurately detect cancerous regions across samples from different platforms and batches. The core of SpaCRD is a category-regularized variational reconstruction-guided bidirectional cross-attention fusion network, which enables the model to adaptively capture latent co-expression patterns between histological features and gene expression from multiple perspectives. Extensive benchmark analysis on 23 matched histology-ST datasets spanning various disease types, platforms, and batches demonstrates that SpaCRD consistently outperforms existing eight state-of-the-art methods in CTR detection.

Junlin Xu, Jincan Li, Feifei Cui, Zhuang Zhang, Jialiang Yang, Shuting Jin, Qiangguo Jin, Yajie Meng

Medical image segmentation plays a crucial role in clinical diagnosis, lesion quantification, and preoperative planning. However, existing Mamba-based architectures, which rely on fixed-direction sequence modeling and flatten images into one-dimensional (1D) sequences, struggle to capture hierarchical anatomical features and spatial dependencies, thereby limiting their representational capacity for complex medical structures. To address these limitations, we propose EccoMamba (Enhanced Cross-hierarchical Continuity Orthogonal Mamba), a U-shaped encoder--decoder framework designed for medical image segmentation. In the encoder's downsampling path, we introduce a Hierarchical Aggregation Enhancement (HAE) module that integrates multi-scale convolutions with hierarchical attention mechanisms. The attention branch further incorporates cross-channel interactions, allowing the model to selectively enhance semantically relevant features while suppressing irrelevant background responses. For skip connections, we design a Structural Continuity Orthogonal (SCO) module to preserve spatial continuity by modeling cross-dimensional dependencies via orthogonal Axial Shifts (AS), thereby mitigating directional bias and improving anatomical consistency. Extensive experiments on four benchmark datasets---ISIC 2018, ISIC 2017, Synapse, and ACDC---show that EccoMamba consistently outperforms state-of-the-art methods in both segmentation accuracy and structural fidelity.

Junhao Xu, Jingjing Chen, Yang Jiao, Jiacheng Zhang, Zhiyu Tan, Hao Li, Yu-Gang Jiang

Recent advances in generative artificial intelligence have enabled the creation of highly realistic image forgeries, raising significant concerns about digital media authenticity. While existing detection methods demonstrate promising results on benchmark datasets, they face critical limitations in real-world applications. First, existing detectors typically fail to detect semantic inconsistencies with the person’s identity, such as implausible behaviors or incompatible environmental contexts in given images. Second, these methods rely heavily on low-level visual cues, making them effective for known forgeries but less reliable against new or unseen manipulation techniques. To address these challenges, we present a novel personalized vision-language model (VLM) that integrates low-level visual artifact analysis and high-level semantic inconsistency detection. Unlike previous VLM-based methods, our approach avoids resource-intensive supervised fine-tuning that often struggles to preserve distinct identity characteristics. Instead, we employ a lightweight method that dynamically encodes identity-specific information into specialized identifier tokens. This design enables the model to learn distinct identity characteristics while maintaining robust generalization capabilities. We further enhance detection capabilities through a lightweight detection adapter that extracts fine-grained information from shallow features of the vision encoder, preserving critical low-level evidence. Comprehensive experiments demonstrate that our approach achieves 94.25% accuracy and 94.08% F1 score, outperforming both traditional forgery detectors and general VLMs while requiring only 10 extra tokens.

Jiao Xu, Junwei Liu, Jiangwei Lao, Qi Zhu, Yunpeng Zhao, Congyun Jin, Shinan Liu, Zhihong Lu, Lihe Zhang, Xin Chen 等

Recent advances in medical multi-modal models focus on specialized image analysis like dermatology, pathology, or radiology. However, they do not fully capture the complexity of real-world clinical diagnostics, which involve heterogeneous inputs and require ongoing contextual understanding during patient-physician interactions. To bridge this gap, we introduce PulseMind, a new family of multi-modal diagnostic models that integrates a systematically curated dataset, a comprehensive evaluation benchmark, and a tailored training framework. Specifically, we first construct a diagnostic dataset, MediScope, which comprises 98,000 real-world multi-turn consultations and 601,500 medical images, spanning over 10 major clinical departments and more than 200 sub-specialties. Then, to better reflect the requirements of real-world clinical diagnosis, we develop the PulseMind Benchmark, a multi-turn diagnostic consultation benchmark with a four-dimensional evaluation protocol comprising proactiveness, accuracy, usefulness, and language quality. Finally, we design a training framework tailored for multi-modal clinical diagnostics, centered around a core component named Comparison-based Reinforcement Policy Optimization (CRPO). Compared to absolute score rewards, CRPO uses relative preference signals from multi-dimensional comparisons to provide stable and human-aligned training guidance. Extensive experiments demonstrate that PulseMind achieves competitive performance on both the diagnostic consultation benchmark and public medical benchmarks.

Huihui Xu, Jin Ye, Hongqiu Wang, Changkai Ji, Jiashi Lin, Ming Hu, Ziyan Huang, Ying Chen, Chenglong Ma, Tianbin Li 等

Recent self-supervised image segmentation models have achieved promising performance on semantic segmentation and class-agnostic instance segmentation. However, their pretraining schedule is multi-stage, requiring a time-consuming pseudo-masks generation process between each training epoch. This time-consuming offline process not only makes it difficult to scale with training dataset size, but also leads to sub-optimal solutions due to its discontinuous optimization routine. To solve these, we first present a novel pseudo-mask algorithm, Fast Universal Agglomerative Pooling (UniAP). Each layer of UniAP can identify groups of similar nodes in parallel, allowing to generate both semantic-level and instance-level and multi-granular pseudo-masks within ens of milliseconds for one image. Based on the fast UniAP, we propose the Scalable Self-Supervised Universal Segmentation (S2-UniSeg), which employs a student and a momentum teacher for continuous pretraining. A novel segmentation-oriented pretext task, Query-wise Self-Distillation (QuerySD), is proposed to pretrain S2-UniSeg to learn the local-to-global correspondences. Under the same setting, S2-UniSeg outperforms the SOTA UnSAM model, achieving notable improvements of AP+6.9 on COCO, AR+11.1 on UVO, PixelAcc+4.5 on COCOStuff-27, RQ+8.0 on Cityscapes. After scaling up to a larger 2M-image subset of SA-1B, S2-UniSeg further achieves performance gains on all four benchmarks.

Junyu Xiong, Yonghui Wang, Weichao Zhao, Chenyu Liu, Bing Yin, Wengang Zhou, Houqiang Li

Understanding multi-page documents poses a significant challenge for multimodal large language models (MLLMs), as it requires fine-grained visual comprehension and multi-hop reasoning across pages. While prior work has explored reinforcement learning (RL) for enhancing advanced reasoning in MLLMs, its application to multi-page document understanding remains underexplored. In this paper, we introduce DocR1, an MLLM trained with a novel RL framework, Evidence Page-Guided GRPO (EviGRPO). EviGRPO incorporates an evidence-aware reward mechanism that promotes a coarse-to-fine reasoning strategy, guiding the model to first retrieve relevant pages before generating answers. To support this, we design a rigorous two-stage annotation pipeline and a curriculum learning strategy that enables effective training with limited supervision. Using this pipeline, we construct two datasets: EviBench, a high-quality training set with 4.8k examples, and ArxivFullQA, a benchmark with 8.6k QA examples over full scientific papers. Extensive experiments across a wide range of benchmarks demonstrate that DocR1 achieves state-of-the-art performance on multi-page tasks while maintaining strong results on single-page benchmarks.

Jingwei Xin, Kai Guo, Jie Li, Nannan Wang

Cloud removal (CR) in remote sensing imagery is a critical yet challenging task due to complex cloud patterns and diverse underlying ground structures. Despite recent progress in generative models such as diffusion models, CR remains limited by their inadequate capability to perceive and reconstruct structured information beneath cloud-covered areas. In this work, we propose a Visibility-guided Semantic Estimation and Reconstruction network for cloud removal (VISER-CR), which reformulates CR as a structure-guided completion problem. Specifically, VISER-CR explicitly models cloud interference via spatial masking, encouraging the model to reason beyond pixel-level appearance and enhance scene-level structural understanding. Moreover, to further improve the representation of structural information, we introduce Patch Saliency Encoding, a self-guided mechanism that implicitly models structural alignment among patches, significantly enhancing clustering consistency and semantic separability in the latent space. This adaptive mechanism guides the network to focus on learning and reconstructing structurally important regions, thereby reducing redundancy and improving overall cloud removal performance. Extensive experiments on multiple benchmark datasets demonstrate the superior effectiveness of our method.

Yun Xiao, Yuhang Wang, Jiandong Jin, Wankang Zhang, Chenglong Li

With the rapid development of the low-altitude economy, multimodal visual tracking in UAV scenarios has attracted extensive attention. UAVs are typically equipped with independent visible (RGB) and thermal infrared (TIR) sensors, resulting in an inherent spatial misalignment between the two modalities. However, existing RGBT tracking methods generally rely on spatially aligned data inputs, making them unsuitable for unaligned RGBT tracking task in UAV scenarios. In this work, we introduce the new task called unaligned UAV RGBT tracking and construct the first large-scale unaligned RGB and TIR video dataset to promote the research and development of this field. The dataset contains 1,453 pairs of UAV-captured RGBT sequences with precise dual-modal bounding box annotations, and covers 42 object categories, 22 typical challenge attributes, and diverse spatial misalignment scales to better simulate real-world challenging scenarios. To address the limitations of existing methods that fail to handle the spatial misalignment issue in UAV scenarios, we propose the novel RGBT tracking approach. In particular, we design a mixture of shift estimation experts module to adaptively estimate the spatial shifts across two modalities at different scales, and a cross-modal alignment and fusion module to further compensate for nonlinear deformations and integrate multimodal information. Extensive experiments on the created dataset demonstrate that the proposed tracker significantly outperforms existing state-of-the-art tracking methods, validating its practicality and robustness in real-world unaligned UAV tracking scenarios.