论文检索

General Machine Learning · Probabilistic Methods

Bruno Viti, Elias Karabelas, Martin Holler

Most machine learning-based image segmentation models produce pixel-wise confidence scores that represent the model’s predicted probability for each class label at every pixel. While this information can be particularly valuable in high-stakes domains such as medical imaging, these scores are heuristic in nature and do not constitute rigorous quantitative uncertainty estimates. Conformal prediction (CP) provides a principled framework for transforming heuristic confidence scores into statistically valid uncertainty estimates. However, applying CP directly to image segmentation ignores the spatial correlations between pixels, a fundamental characteristic of image data. This can result in overly conservative and less interpretable uncertainty estimates. To address this, we propose CONSIGN (*Conformal Segmentation Informed by Spatial Groupings via Decomposition*), a CP-based method that incorporates spatial correlations to improve uncertainty quantification in image segmentation. Our method generates meaningful prediction sets that come with user-specified, high-probability error guarantees. It is compatible with any pre-trained segmentation model capable of generating multiple sample outputs. We evaluate CONSIGN against two CP baselines across three medical imaging datasets and two COCO dataset subsets, using three different pre-trained segmentation models. Results demonstrate that accounting for spatial structure significantly improves performance across multiple metrics and enhances the quality of uncertainty estimates.

Computer Vision · Vision Models & Multimodal

Haozhe Qi, Shaokai Ye, Alexander Mathis, Mackenzie Mathis

Understanding human behavior requires measuring behavioral actions. Due to its complexity, behavior is best mapped onto a rich, semantic structure such as language. Emerging multimodal large language models (MLLMs) are promising candidates, but their fine-grained action understanding ability has not been fully examined. In this work, we reformulate EPIC-KITCHENS-100, one of the largest and most challenging egocentric action recognition datasets, into a MLLM benchmark (EPIC-KITCHENS-100-MQA). We demonstrate that when we sample difficult answers based on specialist models as distractors, leading MLLMs struggle to recognize the correct actions. How can we increase the performance of MLLMs? We curated a supervised finetuning dataset that includes `hard' action recognition, temporal detection, captioning, and free-form question answering to improve models' diverse action understanding capabilities. We introduce a new model called LLaVAction that adds an action token to boost models' attention on visual tokens and a two-stage pipeline to obtain structured actions. LLaVAction greatly improves the MLLMs' ability of action understanding, achieving strong improvements on both MLLM benchmarks (21 points in accuracy over GPT-4o on EPIC-KITCHENS-100-MQA) and established action recognition benchmarks, suggesting that our methods prepare MLLMs to be a promising path forward for complex action tasks. Code, data, the benchmark, and models are available at https://github.com/AdaptiveMotorControlLab/LLaVAction.

Jenny Zhang, Shengran Hu, Cong Lu, Robert Lange, Jeff Clune

Most of today's AI systems are constrained by human-designed, fixed architectures and cannot autonomously and continuously improve themselves. The scientific method, on the other hand, is a cumulative and open-ended system, where each innovation builds upon previous artifacts, enabling future discoveries. There is growing hope that the current manual process of advancing AI could itself be automated. If done safely, such automation would accelerate AI development and allow us to reap its benefits much sooner. This prospect raises the question of how AI systems can endlessly improve themselves while getting better at solving relevant problems. Meta-learning can automate the discovery of novel algorithms, but is limited by first-order improvements and the human design of a suitable search space. The Gödel machine proposed a theoretical alternative: a self-improving AI that repeatedly modifies itself in a provably beneficial manner. Unfortunately, proving that most changes are net beneficial is impossible in practice. We introduce the Darwin Gödel Machine (DGM), a novel self-improving system that iteratively modifies its own code (thereby also improving its ability to modify its own codebase) and empirically validates each change using coding benchmarks. Inspired by Darwinian evolution and open-endedness research, the DGM grows an archive of generated coding agents. It samples agents from this archive, which self-modify to create new, interesting versions of themselves. This open-ended exploration forms a growing tree of diverse, high-quality agents and allows the parallel exploration of many different paths through the search space. Empirically, the DGM automatically improves its coding capabilities (e.g., better code editing tools, long-context window management, peer-review mechanisms), increasing performance on SWE-bench from 20.0% to 50.0%, and on Polyglot from 14.2% to 30.7%. Furthermore, the DGM significantly outperforms baselines without self-improvement or open-ended exploration. All experiments were done with safety precautions (e.g., sandboxing, human oversight). Overall, the DGM represents a significant step toward self-improving AI, capable of gathering its own stepping stones along a path that unfolds into endless innovation.

Theory · Reinforcement Learning and Planning

Bowen Hu, Yixin Tao

We study a principal-agent problem in a Markov Decision Process where the principal provides subsidies to influence the agent's policy, which in turn determines the accrued rewards. Our focus is on designing a robust subsidy scheme that maximizes the principal’s cumulative expected return, even when the agent displays bounded rationality and may deviate from the optimal action policy after receiving subsidies. As a baseline, we first analyze the case of a perfectly rational agent and show that the principal’s optimal subsidy coincides with the policy that maximizes social welfare, the sum of the utilities of both the principal and the agent. We then introduce a bounded-rationality model: the globally $\epsilon$-incentive-compatible agent, who accepts any policy whose expected cumulative utility lies within $\epsilon$ of the personal optimum. In this setting, we prove that the optimal robust subsidy scheme problem simplifies to a one-dimensional concave optimization, revealing that optimal subsidies concentrate along social-welfare-maximizing trajectories. We also bound the associated loss in social welfare. Finally, we investigate a finer-grained, state-wise $\epsilon$-incentive-compatible model. In this setting, we show that under two natural definitions of state-wise incentive-compatibility, the problem becomes intractable: one definition results in a non-Markovian agent action policy, while the other renders the search for an optimal subsidy scheme NP-hard.

Reinforcement Learning · Planning

Shenghua Wan, Le Gan, De-Chuan Zhan

Pre-training world models on large, action-free video datasets offers a promising path toward generalist agents, but a fundamental flaw undermines this paradigm. Prevailing methods train models to predict a single, deterministic future, an objective that is ill-posed for inherently stochastic environments where actions are unknown. We contend that a world model should instead learn a structured, probabilistic representation of the future where predictive uncertainty correctly scales with the temporal horizon. To achieve this, we introduce a pre-training framework, **H**orizon-c**A**librated **U**ncertainty **W**orld **M**odel (HAUWM), built on a probabilistic ensemble that predicts frames at randomly sampled future horizons. The core of our method is a Horizon-Calibrated Uncertainty (HCU) loss, which explicitly shapes the latent space by encouraging predictive variance to grow as the model projects further into the future. This approach yields a latent dynamics model that is not only predictive but also equipped with a reliable measure of temporal confidence. When fine-tuned for downstream control, our pre-trained model significantly outperforms state-of-the-art methods across a diverse suite of benchmarks, including MetaWorld, the DeepMind Control Suite, and RoboDesk. These results highlight the critical role of structured uncertainty in robust decision-making.

General Machine Learning · Representation Learning

Junlin Han, Shengbang Tong, David Fan, Yufan Ren, Koustuv Sinha, Philip Torr, Filippos Kokkinos

Large Language Models (LLMs), despite being trained on text alone, surprisingly develop rich visual priors. These priors allow latent visual capabilities to be unlocked for vision tasks with a relatively small amount of multimodal data, and to perform symbolic visual generation tasks without ever having seen an image. Through systematic analysis, we reveal that visual priors—the implicit, emergent knowledge about the visual world acquired during language pre-training—are composed of separable perception and reasoning priors with unique scaling trends and origins. We show that an LLM's latent visual reasoning ability is predominantly developed by pre-training on reasoning-centric data (\eg, code, math, academia) and scales progressively. This reasoning prior acquired from language pre-training is transferable and universally applicable to visual reasoning. In contrast, the perception prior emerges more diffusely from broad corpora, and perception ability is more sensitive to the vision encoder and visual instruction tuning data. In parallel, text describing the visual world proves crucial, though its performance impact saturates rapidly. Leveraging these insights, we propose a data-centric recipe for pre-training vision-aware LLMs and verify it in 1T token scale pre-training. Our findings are grounded in over 100 controlled experiments consuming 500,000 GPU-hours, spanning the full MLLM construction pipeline—from LLM pre-training to visual alignment and supervised multimodal fine-tuning—across five model scales, a wide range of data categories and mixtures, and multiple adaptation setups. Along with our main findings, we also propose and investigate several hypotheses, and introduce a Multi-Level Existence Bench (MLE-Bench) to facilitate future research. Together, this work provides a new way of deliberately cultivating visual priors from language pre-training, paving the way for the next generation of multimodal LLMs. We recommend a visit to our project page (https://junlinhan.github.io/projects/lsbs/) for an interactive reading.

Reinforcement Learning · Everything Else

Zequan Wu, Mengye Ren

The Forward-Forward (FF) Algorithm is a recently proposed learning procedure for neural networks that employs two forward passes instead of the traditional forward and backward passes used in backpropagation. However, FF remains largely confined to supervised settings, leaving a gap at domains where learning signals can be yielded more naturally such as RL. In this work, inspired by FF's goodness function using layer activity statistics, we introduce Action-conditioned Root mean squared Q-Functions (ARQ), a novel value estimation method that applies a goodness function and action conditioning for local RL using temporal difference learning. Despite its simplicity and biological grounding, our approach achieves superior performance compared to state-of-the-art local backprop-free RL methods in the MinAtar and the DeepMind Control Suite benchmarks, while also outperforming algorithms trained with backpropagation on most tasks.

Optimization · Everything Else

Ruobing Wang, Xin Li, Mingzhong Wang

We propose MILPnet, a multi-scale hybrid attention framework that models Mixed Integer Linear Programming (MILP) problems as geometric sequences rather than graphs. This approach directly addresses the challenge of Foldable MILP instances, a class of problems that graph-based models, specifically Graph Neural Networks (GNNs), fail to distinguish due to expressiveness limits imposed by the Weisfeiler-Lehman test. By representing MILPs through sequences of constraint and objective features, MILPnet captures both local and global geometric structure using a theoretically grounded multi-scale attention mechanism. We theoretically prove that MILPnet can approximate feasibility, optimal objective value, and optimal solution mappings over a measurable topological space with arbitrarily small error. Empirically, MILPnet outperforms graph-based methods in feasibility prediction accuracy and convergence speed on Foldable MILPs, while using significantly fewer parameters. It also generalizes effectively among problem scales and demonstrates strong performance on real-world MILP benchmarks when integrated into an end-to-end solver pipeline. Our code is available.

Deep Learning · Everything Else

Xiaoyang Yi, Li Peng, Yuru Bao, Jian Zhang

Federated learning (FL), as a privacy-preserving distributed machine learning paradigm, enables clients to collaboratively train a global model without sharing local data. However, in real-world scenarios, domain shift caused by different source clients leads to structural discrepancies in the feature space, resulting in performance degradation of the global model. Although existing prototype-based FL methods offer improvements in cross-domain feature alignment, they still struggle to adapt to dynamic semantic structures and fail to continuously respond to the changing semantic separability and variance structure during training. To address this, we propose FedPTE, an FL framework with prototype topology evolution. Specifically, FedPTE treats prototype clusters as variable topological units, employing Bayesian Gaussian Mixture Models and marginal likelihood ratios on the server to perform probabilistic inference, which enables adaptive structural adjustments. Meanwhile, FedPTE introduces a stability constraint mechanism to balance the adaptability of topological evolution and training stability. By conducting prototype topology-aware contrastive learning on clients, it enhances the discriminability and cross-domain consistency of features. Experimental results demonstrate that FedPTE achieves superior performance across multiple cross-domain datasets, showcasing its strong expressiveness and generalization capability in heterogeneous domains.

Computer Vision · Image and Video Generation

Ji Xie, trevor darrell, Luke Zettlemoyer, Xudong Wang

Unified multimodal models (UMMs) unify visual understanding and generation within a single architecture. However, conventional training relies on image–text pairs (or sequences) whose captions are typically sparse and miss fine-grained visual details, even when they use hundreds of words to describe a simple image. We introduce **Reconstruction Alignment (RecA)**, a resource-efficient post-training method that leverages visual understanding encoder embeddings as dense “text prompts,” providing rich supervision without captions. Concretely, RecA conditions a UMM on its own visual understanding embeddings and optimizes it to reconstruct the input image with a self-supervised reconstruction loss, thereby realigning understanding and generation. Despite its simplicity, RecA is broadly applicable: across autoregressive, masked-autoregressive, and diffusion-based UMMs, it consistently improves generation and editing fidelity. With only 27 GPU-hours, post-training with RecA substantially improves image generation performance on GenEval (0.73 → 0.90) and DPGBench (80.93 → 88.15), while also boosting editing benchmarks (ImgEdit 3.38 → 3.75, GEdit 6.94 → 7.27). Notably, RecA surpasses much larger open-source models and applies broadly across diverse UMM architectures, establishing it as an efficient and general post-training alignment strategy for UMMs.

Computer Vision · Image and Video Generation

Xinya Ji, Sebastian Weiss, Manuel Kansy, Jacek Naruniec, Xun Cao, Barbara Solenthaler, Derek Bradley

Despite recent progress in 3D Gaussian-based head avatar modeling, efficiently generating high fidelity avatars remains a challenge. Current methods typically rely on extensive multi-view capture setups or monocular videos with per-identity optimization during inference, limiting their scalability and ease of use on unseen subjects. To overcome these efficiency drawbacks, we propose FastGHA, a feed-forward method to generate high-quality Gaussian head avatars from only a few input images while supporting real-time animation. Our approach directly learns a per-pixel Gaussian representation from the input images, and aggregates multi-view information using a transformer-based encoder that fuses image features from both DINOv3 and Stable Diffusion VAE. For real-time animation, we extend the explicit Gaussian representations with per-Gaussian features and introduce a lightweight MLP-based dynamic network to predict 3D Gaussian deformations from expression codes. Furthermore, to enhance geometric smoothness of the 3D head, we employ point maps from a pre-trained large reconstruction model as geometry supervision. Experiments show that our approach significantly outperforms existing methods in both rendering quality and inference efficiency, while supporting real-time dynamic avatar animation.

Computer Vision · Image and Video Generation

Tong Shao, Yusen Fu, Guoying Sun, Jingde Kong, Zhuotao Tian, Jingyong Su

Although Diffusion Transformer (DiT) has emerged as a predominant architecture for image and video generation, its iterative denoising process results in slow inference, which hinders broader applicability and development. Caching-based methods achieve training-free acceleration, while suffering from considerable computational error. Existing methods typically incorporate error correction strategies such as pruning or prediction to mitigate it. However, their fixed caching strategy fails to adapt to the complex error variations during denoising, which limits the full potential of error correction. To tackle this challenge, we propose a novel fidelity-optimization plugin for existing error correction methods via cumulative error minimization, named CEM. CEM predefines the error to characterize the sensitivity of model to acceleration jointly influenced by timesteps and cache intervals. Guided by this prior, we formulate a dynamic programming algorithm with cumulative error approximation for strategy optimization, which achieves the caching error minimization, resulting in a substantial improvement in generation fidelity. CEM is model-agnostic and exhibits strong generalization, which is adaptable to arbitrary acceleration budgets. It can be seamlessly integrated into existing error correction frameworks and quantized models without introducing any additional computational overhead. Extensive experiments conducted on nine generation models and quantized methods across three tasks demonstrate that CEM significantly improves generation fidelity of existing acceleration models, and outperforms the original generation performance on FLUX.1-dev, PixArt-$\alpha$, StableDiffusion1.5 and Hunyuan. Our code is released publicly at https://github.com/leaves162/CEM.

Theory · Interpretability and Visualization

Tianxiang Dai, Jonathan Fan

Multi-Resolution Hash Encoding (MHE), the foundational technique behind Instant Neural Graphics Primitives, provides a powerful parameterization for neural fields. However, its spatial behavior lacks rigorous understanding from a physical systems perspective, leading to reliance on heuristics for hyperparameter selection. This work introduces a novel analytical approach that characterizes MHE by examining its Point Spread Function (PSF), which is analogous to the Green's function of the system. This methodology enables a quantification of the encoding's spatial resolution and fidelity. We derive a closed-form approximation for the collision-free PSF, uncovering inherent grid-induced anisotropy and a logarithmic spatial profile. We establish that the idealized spatial bandwidth, specifically the Full Width at Half Maximum (FWHM), is determined by the average resolution, $N_{\text{avg}}$. This leads to a counterintuitive finding: the effective resolution of the model is governed by the broadened empirical FWHM (and therefore $N_{\text{avg}}$), rather than the finest resolution $N_{\max}$, a broadening effect we demonstrate arises from optimization dynamics. Furthermore, we analyze the impact of finite hash capacity, demonstrating how collisions introduce speckle noise and degrade the Signal-to-Noise Ratio (SNR). Leveraging these theoretical insights, we propose Rotated MHE (R-MHE), an architecture that applies distinct rotations to the input coordinates at each resolution level. R-MHE mitigates anisotropy while maintaining the efficiency and parameter count of the original MHE. This study establishes a methodology based on physical principles that moves beyond heuristics to characterize and optimize MHE.

Deep Learning · Theory

Shuofeng Zhang, Ard Louis

For overparameterized linear regression with isotropic Gaussian design and minimum-$\ell_p$ interpolator $p\in(1,2]$, we give a unified, high-probability characterization for the scaling of the family of parameter norms $ \\{ \lVert \widehat{w_p} \rVert_r \\}_{r \in [1,p]} $ with sample size. We solve this basic, but unresolved question through a simple dual-ray analysis, which reveals a competition between a signal *spike* and a *bulk* of null coordinates in $X^\top Y$, yielding closed-form predictions for (i) a data-dependent transition $n_\star$ (the "elbow"), and (ii) a universal threshold $r_\star=2(p-1)$ that separates $\lVert \widehat{w_p} \rVert_r$'s which plateau from those that continue to grow with an explicit exponent. This unified solution resolves the scaling of *all* $\ell_r$ norms within the family $r\in [1,p]$ under $\ell_p$-biased interpolation, and explains in one picture which norms saturate and which increase as $n$ grows. We then study diagonal linear networks (DLNs) trained by gradient descent. By calibrating the initialization scale $\alpha$ to an effective $p_{\mathrm{eff}}(\alpha)$ via the DLN separable potential, we show empirically that DLNs inherit the same elbow/threshold laws, providing a predictive bridge between explicit and implicit bias. Given that many generalization proxies depend on $\lVert \widehat {w_p} \rVert_r$, our results suggest that their predictive power will depend sensitively on which $l_r$ norm is used.

Applications · Robotics

XUDONG WANG, Gan Li, Zhiyu Liu, Yao Wang, Lianqing Liu, Zhi Han

Deploying vision-and-language navigation (VLN) agents requires adaptation across diverse scenes and environments, but fine-tuning on a specific scenario often causes catastrophic forgetting in others, which severely limits flexible long-term deployment. We formalize this challenge as the all-day multi-scenes lifelong VLN (AML-VLN) problem. Existing parameter-efficient adapters (e.g., LoRA and its variants) are limited by their two-dimensional matrix form, which fails to capture the multi-hierarchical navigation knowledge spanning multiple scenes and environments. To address this, we propose Tucker Adaptation (TuKA), which represents the multi-hierarchical navigation knowledge as a high-order tensor and leverages Tucker decomposition to decouple the knowledge into shared subspaces and scenario-specific experts. We further introduce a decoupled knowledge incremental learning strategy to consolidate shared subspaces while constraining specific experts for decoupled lifelong learning. Building on TuKA, we also develop a VLN agent named AlldayWalker, which continually learns across multiple navigation scenarios, achieving all-day multi-scenes navigation. Extensive experiments show that AlldayWalker consistently outperforms state-of-the-art baselines.

General Machine Learning · Representation Learning

Youqing Wang, Yu Cao, Jinlu Wang, Xiang Xu, Jiapu Wang, Tengfei Liu, Junbin Gao, Jipeng Guo

Multi-view data usually suffer from partially missing views in open scenarios, which inevitably degrades clustering performance. The incomplete multi-view clustering (IMVC) has attracted increasing attention and achieved significant success. Although existing imputation-based IMVC methods perform well, they still face one crucial limitation, i.e., view recovery and subspace representation lack explicit alignment and collaborative interaction in exploring complementarity and consistency across multiple views. To this end, this study proposes a novel IMVC method to Align collaborative view Recovery and tensorial Subspace Learning via latent representation (ARSL-IMVC). Specifically, the ARSL-IMVC infers the complete view from view-shared latent representation and view-specific estimator with Hilbert-Schmidt Independence Criterion regularizer, reshaping the consistent and diverse information intrinsically embedded in original multi-view data. Then, the ARSL-IMVC learns the view-shared and view-specific subspace representations from latent feature and recovered views, and models high-order correlations at the global and local levels in the unified low-rank tensor space. Thus, leveraging the latent representation as a bridge in a unified framework, the ARSL-IMVC seamlessly aligns the complementarity and consistency exploration across view recovery and subspace representation learning, negotiating with each other to promote clustering. Extensive experimental results on seven datasets demonstrate the powerful capacity of ARSL-IMVC in complex incomplete multi-view clustering tasks under various view missing scenarios. The source code is publicly available at https://github.com/caoyu110/ARSL-IMVC.

Optimization · Zero-order and Black-box Optimization

Shanwen Mao, Hao Zhang, Jiasheng Li, Haoyu Qiao, Chenxin Cai, Tingting Wu, Jie Liu

With the rapid scaling of large language models, achieving efficient compression while maintaining model performance has become a critical challenge. To address the limitations of existing non-uniform quantization methods, which typically rely on fixed codebooks and require costly optimization, we propose a novel arbitrary bit-width non-uniform Quantization (NuBitQ). The framework enables flexible, layer-specific quantization strategies, significantly enhancing adaptability and efficiency. Notably, traditional outlier compensation methods used in uniform quantization are ill-suited for the anomalous distribution characteristics encountered in our context. To address this, we design a novel outlier evaluation metric that integrates weight perturbation, activation distribution, and perturbation propagation. Based on this metric, we further develop an Outlier Compensation Plugin (OCP) that implements multi-level, fine-grained outlier compensation strategies, effectively mitigating performance degradation caused by outliers. Our approach avoids direct complex Hessian computation and fine-tuning, offering strong applicability and scalability. Extensive experiments on multiple tasks and across various model series demonstrate the effectiveness of the proposed approach.

Deep Learning · Generative Models and Autoencoders

Christian Belardi, Justin Lovelace, Kilian Weinberger, Carla Gomes

Guided diffusion sampling relies on approximating often intractable likelihood scores, which introduces significant noise into the sampling dynamics. We propose using adaptive moment estimation to stabilize these noisy likelihood scores during sampling. Despite its simplicity, our approach achieves state-of-the-art results on image restoration and class-conditional generation tasks, outperforming more complicated methods, which are often computationally more expensive. We provide empirical analysis of our method on both synthetic and real data, demonstrating that mitigating gradient noise through adaptive moments offers an effective way to improve alignment.

Reinforcement Learning · Deep RL

Chenghua Huang, Lu Wang, Fangkai Yang, Pu Zhao, Qingwei Lin, Dongmei Zhang, Saravan Rajmohan

In this paper, we explore how directly pretraining a value model simplifies and stabilizes reinforcement learning from human feedback (RLHF). In reinforcement learning, value estimation is the key to policy optimization, distinct from reward supervision. The value function predicts the \emph{return-to-go} of a partial answer, that is, how promising the partial answer is if it were continued to completion. In RLHF, however, the standard pipeline first pretrains a reward model and then learns a value function online, even though no new reward signals are available once preference data is collected. This makes critic learning redundant, as the process of training a reward model and then deriving a value model is informationally equivalent to directly pretraining a value model. Importantly, this requires no additional supervision, and our value model is trained on exactly the same data used for reward modeling. Building on this insight, we introduce \emph{Decoupled Value Policy Optimization} (DVPO), a framework that pretrains a \emph{Global Value Model} (GVM) offline and freezes it as a universal critic for policy learning. The GVM provides stable, fine-grained credit assignment without critic drift or trajectory sampling. Experiments across MT-Bench, Alpaca-Eval, and Arena-Hard demonstrate that DVPO matches or surpasses state-of-the-art RLHF methods. These results highlight RLHF can be reframed as policy-only optimization guided by a single pretrained value model. The implementation code for our method is available in \url{https://github.com/microsoft/DKI_LLM/tree/main/dvpo}

Applications · Genetics, Cell Biology, Health, etc

Linshan Wu, Jia-Xin Zhuang, Hao CHEN

Pan-cancer screening in large-scale CT scans remains challenging for existing AI methods, primarily due to the difficulty of localizing diverse types of tiny lesions in large CT volumes. The extreme foreground-background imbalance significantly hinders models from focusing on diseased regions, while redundant focus on healthy regions not only decreases the efficiency but also increases false positives. Inspired by radiologists' glance and focus diagnostic strategy, we introduce GF-Screen, a Glance and Focus reinforcement learning framework for pan-cancer screening. GF-Screen employs a Glance model to localize the diseased regions and a Focus model to precisely segment the lesions, where segmentation results of the Focus model are leveraged to reward the Glance model via Reinforcement Learning (RL). Specifically, the Glance model crops a group of sub-volumes from the entire CT volume and learns to select the sub-volumes with lesions for the Focus model to segment. Given that the selecting operation is non-differentiable for segmentation training, we propose to employ the segmentation results to reward the Glance model. To optimize the Glance model, we introduce a novel group relative learning paradigm, which employs group relative comparison to prioritize high-advantage predictions and discard low-advantage predictions within sub-volume groups, not only improving efficiency but also reducing false positives. In this way, for the first time, we effectively extend cutting-edge RL techniques to tackle the specific challenges in pan-cancer screening. We conduct training and validation on a large-scale pan-cancer dataset comprising 5,117 CT scans. Extensive experiments on 16 internal and 7 external datasets across 9 lesion types demonstrated the effectiveness of GF-Screen. Notably, GF-Screen leads the public validation leaderboard of MICCAI FLARE25 pan-cancer challenge, surpassing the FLARE24 champion solution by a large margin (+25.6% DSC and +28.2% NSD). In addition, through discarding redundant regions, GF-Screen reduces the computation costs by 5.7 times, significantly improving inference efficiency. The superior performance of GF-Screen remarks a novel and practical breakthrough in pan-cancer screening. Code is available at https://github.com/Luffy03/GF-Screen.