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Computer Vision · Image and Video Generation

Matthieu Terris, Samuel Hurault, Maxime Song, Julián Tachella

Most existing learning-based methods for solving imaging inverse problems can be roughly divided into two classes: iterative algorithms, such as plug-and-play and diffusion methods leveraging pretrained denoisers, and unrolled architectures that are trained end-to-end for specific imaging problems. Iterative methods in the first class are computationally costly and often yield suboptimal reconstruction performance, whereas unrolled architectures are generally problem-specific and require expensive training. In this work, we propose a novel non-iterative, lightweight architecture that incorporates knowledge about the forward operator (acquisition physics and noise parameters) without relying on unrolling. Our model is trained to solve a wide range of inverse problems, such as deblurring, magnetic resonance imaging, computed tomography, inpainting, and super-resolution, and handles arbitrary image sizes and channels, such as grayscale, complex, and color data. The proposed model can be easily adapted to unseen inverse problems or datasets with a few fine-tuning steps (up to a few images) in a self-supervised way, without ground-truth references. Throughout a series of experiments, we demonstrate state-of-the-art performance from medical imaging to low-photon imaging and microscopy. Our code is available at https://github.com/matthieutrs/ram.

Computer Vision · Image and Video Generation

Yu Li, Menghan Xia, Gongye Liu, Jianhong Bai, Xintao WANG, Conglang Zhang, Yuxuan Lin, Ruihang Chu, Pengfei Wan, Yujiu Yang

Recent Text-to-Video (T2V) models have demonstrated powerful capability in visual simulation of real-world geometry and physical laws, indicating its potential as implicit world models. Inspired by this, we explore the feasibility of leveraging the video generation prior for viewpoint planning from given 4D scenes, since videos internally accompany dynamic scenes with natural viewpoints. To this end, we propose a two-stage paradigm to adapt pre-trained T2V models for viewpoint prediction, in a compatible manner. First, we inject the 4D scene representation into the pre-trained T2V model via an adaptive learning branch, where the 4D scene is viewpoint-agnostic and the conditional generated video embeds the viewpoints visually. Then, we formulate viewpoint extraction as a hybrid-condition guided camera extrinsic denoising process. Specifically, a camera extrinsic diffusion branch is further introduced onto the pre-trained T2V model, by taking the generated video and 4D scene as input. Experimental results show the superiority of our proposed method over existing competitors, and ablation studies validate the effectiveness of our key technical designs. To some extent, this work proves the potential of video generation models toward 4D interaction in real world.

Gongjie Zhang, Wenhao Li, Quanhao Qian, Jiuniu Wang, Deli Zhao, Shijian Lu, Ran Xu

Multimodal Large Language Models (MLLMs) that directly process RGB inputs for tasks like 3D localization and navigation have shown remarkable potential. However, we argue that these ``RGB-only'' approaches are fundamentally flawed in their ability to generalize across cameras. By ignoring camera parameters, they entangle an object's physical properties with the camera's perspective, creating an irresolvable ambiguity. We show this leads MLLMs to overfit to the training camera distribution, rather than learning true and generalizable 3D geometric principles. To address this, we propose Camera-Aware MLLM framework for spatial MLLMs. It learns generalizable spatial reasoning by: (i) injecting camera intrinsics via a dense embedding that conditions each visual token; (ii) introducing a camera-aware data augmentation strategy that synthetically varies camera parameters, forcing the model to disentangle camera properties from scene content; and (iii) distilling geometric priors from a 3D vision foundation model. Extensive experiments demonstrate that camera-aware MLLMs substantially outperform their naive counterparts, particularly in cross-camera generalization tests on spatially-grounded tasks, indicating that camera-awareness is not only beneficial but also a prerequisite for robust and generalizable spatial intelligence in MLLMs.

Computer Vision · Everything Else

Qingxuan Wu, Zhiyang Dou, chuan guo, Yiming Huang, Qiao Feng, Bing Zhou, Jian Wang, Lingjie Liu

Modeling human–human interactions from text remains challenging because it requires not only realistic individual dynamics but also precise, text-consistent spatiotemporal coupling between agents. Currently, progress is hindered by 1) limited two-person training data, inadequate to capture the diverse intricacies of two-person interactions; and 2) insufficiently fine-grained text-to-interaction modeling, where language conditioning collapses rich, structured prompts into a single sentence embedding. To address these limitations, we propose our Text2Interact framework, designed to generate realistic, text-aligned human–human interactions through a scalable high-fidelity interaction data synthesizer and an effective spatiotemporal coordination pipeline. First, we present InterCompose, a scalable synthesis-by-composition pipeline that aligns LLM-generated interaction descriptions with strong single-person motion priors. Given a prompt and a motion for an agent, InterCompose retrieves candidate single-person motions, trains a conditional reaction generator for another agent, and uses a neural motion evaluator to filter weak or misaligned samples—expanding interaction coverage without extra capture. Second, we propose InterActor, a text-to-interaction model with word-level conditioning that preserves token-level cues (initiation, response, contact ordering) and an adaptive interaction loss that emphasizes contextually relevant inter-person joint pairs, improving coupling and physical plausibility for fine-grained interaction modeling. Extensive experiments show consistent gains in motion diversity, fidelity, and generalization, including out-of-distribution scenarios and user studies. Code will be released at github.com/Qingxuan-Wu/Text2Interact.

Reinforcement Learning · Everything Else

Qili Shen, Kairui Feng, Ang He, Xuanhong Chen, Dake Zhang

Recent work increasingly adopts AI for Science (AI4S) models to replace expensive PDE solvers as simulation environments for reinforcement learning (RL), enabling faster training in complex physical control tasks. However, using approximate simulators introduces modeling errors that affect the learned policy. In this paper, we introduce a unified $\varepsilon$-$N$ framework that quantifies the minimal computational cost $N^*(\varepsilon)$ required for an AI4S model to ensure that tabular RL can estimate the value function with unbiasedness, with probability at least $1 - \delta$. This characterization allows us to connect surrogate accuracy, grid resolution, and RL policy quality under a shared probabilistic language. We analyze how the discretization level $K$ of AI4S and RL space governs both PDE surrogate error and RL lattice approximation error, and we employ spectral theory and Sobolev estimates to derive optimal grid strategies that minimize total cost while preserving learning fidelity. Our theory reveals that different systems, such as ODE- and PDE-governed environments, require different allocations of effort between physical simulation and RL optimization. Overall, our framework offers a principled foundation for designing efficient, scalable, and cost-aware AI4S-RL systems with provable learning guarantees.

Theory · Learning Theory

Lukas Gonon, Rodrigo Martínez-Peña, Juan-Pablo Ortega

Quantum reservoir computing uses the dynamics of quantum systems to process temporal data, making it particularly well-suited for machine learning with noisy intermediate-scale quantum devices. Recent developments have introduced feedback-based quantum reservoir systems, which process temporal information with comparatively fewer components and enable real-time computation while preserving the input history. Motivated by their promising empirical performance, in this work, we study the approximation capabilities of feedback-based quantum reservoir computing. More specifically, we are concerned with recurrent quantum neural networks, which are quantum analogues of classical recurrent neural networks. Our results show that regular state-space systems can be approximated using quantum recurrent neural networks without the curse of dimensionality and with the number of qubits only growing logarithmically in the reciprocal of the prescribed approximation accuracy. Notably, our analysis demonstrates that quantum recurrent neural networks are universal with linear readouts, making them both powerful and experimentally accessible. These results pave the way for practical and theoretically grounded quantum reservoir computing with real-time processing capabilities.

Computer Vision · Vision Models & Multimodal

Xuyou Yang, Yucheng Zhao, Wenxuan Zhang, Immanuel Koh

Multi-modal Large Language Models (MLLMs) represent a significant advancement in artificial intelligence. Among the growing capabilities exhibited by MLLMs, abilities to understand and reason in real-world environments stand out as particularly vital as a fundamental prerequisite for a wide array of real-world applications. The current methods for evaluating MLLMs often fall short in their ability to comprehensively assess these crucial capabilities. However, being able to reason on complex environment-scale spaces, for example, room spaces, building spaces, and even urban spaces, and to predict the future and plan actions, is essential for humans and various autonomous agents to survive in the real physical world. To address these gaps, we propose a visual-question-answering benchmark, **SpaCE-Eval** (**Spa**tial Reasoning, **C**ommonsense Knowledge and **E**nvironment Interaction) in the real world, designed to evaluate some of MLLM’s most important reasoning abilities in real-world environments. As the name suggests, it challenges the models to reason on complex spatial scenarios, invoke commonsense knowledge of the physical world, and interact with the environment. The dataset consists of all new diagrams purposefully produced by humans, where diagram-question pairs are meticulously refined and selected through a rigorous pipeline. Additionally, with the benchmark, we evaluate a selection of leading MLLMs, both proprietary and open source. The results suggest that a significant enhancement of MLLMs in reasoning in the real physical world is necessary to realise more advanced general artificial intelligence.

Computer Vision · Vision Models & Multimodal

Huan-ang Gao, Zikang Zhang, Tianwei Luo, Kaisen Yang, Xinzhe Juan, Jiahao Qiu, Tianxing Chen, Bingxiang He, Hao Zhao, Hao Zhou 等

Large Language Model (LLM) agents, while proficient in the digital realm, face a significant gap in physical-world deployment due to the challenge of forming and maintaining a robust spatial mental model. We identify three core cognitive challenges hindering this transition: spatial reasoning, long-horizon state tracking via mental simulation, and active exploration under partial observation. To isolate and evaluate these faculties, we introduce \textbf{CubeBench}, a novel generative benchmark centered on the Rubik's Cube. CubeBench uses a three-tiered diagnostic framework that progressively assesses agent capabilities, from foundational state tracking with full symbolic information to active exploration with only partial visual data. Our experiments on leading LLMs reveal critical limitations, including a uniform 0.00\% pass rate on all long-horizon tasks, exposing a fundamental failure in long-term planning. We also propose a diagnostic framework to isolate these cognitive bottlenecks by providing external solver tools. By analyzing the failure modes, we provide key insights to guide the development of more physically-grounded intelligent agents.

Computer Vision · Image and Video Generation

Jay Zhangjie Wu, Xuanchi Ren, Tianchang Shen, Tianshi Cao, Kai He, Yifan Lu, Ruiyuan Gao, Enze Xie, Shiyi Lan, Jose M. Alvarez 等

Recent advances in large generative models have greatly enhanced both image editing and in-context image generation, yet a critical gap remains in ensuring physical consistency, where edited objects must remain coherent. This capability is especially vital for world simulation related tasks. In this paper, we present ChronoEdit, a framework that reframes image editing as a video generation problem. First, ChronoEdit treats the input and edited images as the first and last frames of a video, allowing it to leverage large pretrained video generative models that capture not only object appearance but also the implicit physics of motion and interaction through learned temporal consistency. Second, ChronoEdit introduces a temporal reasoning stage that explicitly performs editing at inference time. Under this setting, target frame is jointly denoised with reasoning tokens to imagine a plausible editing trajectory that constrains the solution space to physically viable transformations. The reasoning tokens are then dropped after a few steps to avoid the high computational cost of rendering a full video. To validate ChronoEdit, we introduce PBench-Edit, a new benchmark of image–prompt pairs for contexts that require physical consistency, and demonstrate that ChronoEdit surpasses state-of-the-art baselines in both visual fidelity and physical plausibility. Project page for code and models: https://research.nvidia.com/labs/toronto-ai/chronoedit

Applications · Physics

David Park, Shuhang Li, Yi Huang, Xihaier Luo, Haiwang Yu, Yeonju Go, Christopher Pinkenburg, YUEWEI LIN, Shinjae Yoo, Joseph Osborn 等

Large language models have revolutionized artificial intelligence by enabling large, generalizable models trained through self-supervision. This paradigm has inspired the development of scientific foundation models (FMs). However, applying this capability to experimental particle physics is challenging due to the sparse, spatially distributed nature of detector data, which differs dramatically from natural language. This work addresses if an FM for particle physics can scale and generalize across diverse tasks. We introduce a new dataset with more than 11 million particle collision events and a suite of downstream tasks and labeled data for evaluation. We propose a novel self-supervised training method for detector data and demonstrate its neural scalability with models that feature up to 188 million parameters. With frozen weights and task-specific adapters, this FM consistently outperforms baseline models across all downstream tasks. The performance also exhibits robust data-efficient adaptation. Further analysis reveals that the representations extracted by the FM are task-agnostic but can be specialized via a single linear mapping for different downstream tasks.

Computer Vision · Segmentation

Yuejiao Su, Yi Wang, Lei Yao, Yawen Cui, Lap-Pui Chau

A fine-grained understanding of egocentric human-environment interactions is crucial for developing next-generation embodied agents. One fundamental challenge in this area involves accurately parsing hands and active objects. While transformer-based architectures have demonstrated considerable potential for such tasks, several key limitations remain unaddressed: 1) existing query initialization mechanisms rely primarily on semantic cues or learnable parameters, demonstrating limited adaptability to changing active objects across varying input scenes; 2) previous transformer-based methods utilize pixel-level semantic features to iteratively refine queries during mask generation, which may introduce interaction-irrelevant content into the final embeddings; and 3) prevailing models are susceptible to ``interaction illusion'', producing physically inconsistent predictions. To address these issues, we propose an end-to-end Interaction-aware Transformer (InterFormer), which integrates three key components, i.e., a Dynamic Query Generator (DQG), a Dual-context Feature Selector (DFS), and the Conditional Co-occurrence (CoCo) loss. The DQG explicitly grounds query initialization in the spatial dynamics of hand-object contact, enabling targeted generation of interaction-aware queries for hands and various active objects. The DFS fuses coarse interactive cues with semantic features, thereby suppressing interaction-irrelevant noise and emphasizing the learning of interactive relationships. The CoCo loss incorporates hand-object relationship constraints to enhance physical consistency in prediction. Our model achieves state-of-the-art performance on both the EgoHOS and the challenging out-of-distribution mini-HOI4D datasets, demonstrating its effectiveness and strong generalization ability. Code and models are publicly available at https://github.com/yuggiehk/InterFormer.

Computer Vision · 3D Rendering & Reconstruction

Bingchen Miao, Rong Wei, Zhiqi Ge, Xiaoquan sun, Shiqi Gao, Jingzhe Zhu, Renhan Wang, Siliang Tang, Jun Xiao, Rui Tang 等

3D Gaussian Splatting (3DGS), a 3D representation method with photorealistic real-time rendering capabilities, is regarded as an effective tool for narrowing the sim-to-real gap. However, it lacks fine-grained semantics and physical executability for Visual-Language Navigation (VLN). To address this, we propose **SAGE-3D** (**S**emantically and Physically **A**ligned **G**aussian **E**nvironments for **3D** Navigation), a new paradigm that upgrades 3DGS into an executable, semantically and physically aligned environment. It comprises two components: **(1) Object-Centric Semantic Grounding**, which adds object-level fine-grained annotations to 3DGS; and **(2) Physics-Aware Execution Jointing**, which embeds collision objects into 3DGS and constructs rich physical interfaces. We release **InteriorGS**, containing 1K object-annotated 3DGS indoor scene data, and introduce **SAGE-Bench**, the first 3DGS-based VLN benchmark with 2M VLN data. Experiments show that 3DGS scene data is more difficult to converge, while exhibiting strong generalizability, improving baseline performance by 31% on the VLN-CE Unseen task.

Applications · Robotics

Yuecheng Liu, DaFeng Chi, Shiguang Wu, Zhanguang Zhang, Yuzheng Zhuang, Bowen Yang, He Zhu, Lingfeng Zhang, Pengwei Xie, David Gamaliel Arcos Bravo 等

Recent advances in multimodal large language models (MLLMs) have opened new opportunities for embodied intelligence, enabling multimodal understanding, reasoning, and interaction, as well as continuous spatial decision-making. Nevertheless, current MLLM-based embodied systems face two critical limitations. First, **Geometric Adaptability Gap:** models trained solely on 2D inputs or with hard-coded 3D geometry injection suffer from either insufficient spatial information or restricted 2D generalization, leading to poor adaptability across tasks with diverse spatial demands. Second, **Embodiment Constraint Gap**: prior work often neglects the physical constraints of real robots, resulting in task plans that are theoretically valid but practically infeasible.To address these gaps, we introduce **OmniEVA** -- an embodied versatile planner that enables advanced embodied reasoning and task planning through two pivotal innovations: (1) a **Task-Adaptive 3D Grounding** mechanism, which uses a gated router to dynamically inject 3D features based on task context, enabling selective geometric reasoning. (2) an **Embodiment-Aware Reasoning** framework that incorporates task goals and physical constraints into the reasoning loop, ensuring executable plans. Extensive experiments show that OmniEVA achieves state-of-the-art performance on 7 of 8 embodied reasoning benchmarks and excels in downstream tasks such as object navigation and mobile manipulation. Evaluations on proposed primitive and composite benchmarks confirm its robust and versatile planning capabilities.

Applications · Robotics

yongkang li, Kaixin Xiong, Xiangyu Guo, Fang Li, Sixu Yan, Gangwei Xu, Lijun Zhou, Long Chen, Haiyang Sun, Bing Wang 等

Recent studies have explored leveraging the world knowledge and cognitive capabilities of Vision-Language Models (VLMs) to address the long-tail problem in end-to-end autonomous driving. However, existing methods typically formulate trajectory planning as a language modeling task, where physical actions are output in the language space, potentially leading to issues such as format-violating outputs, infeasible actions, and slow inference speeds. In this paper, we propose ReCogDrive, a novel **Re**inforced **Cog**nitive framework for end-to-end autonomous **Driv**ing, unifying driving understanding and planning by integrating an autoregressive model with a diffusion planner. First, to instill human driving cognition into the VLM, we introduce a hierarchical data pipeline that mimics the sequential cognitive process of human drivers through three stages: generation, refinement, and quality control. Building on this cognitive foundation, we then address the language-action mismatch by injecting the VLM's learned driving priors into a diffusion planner to efficiently generate continuous and stable trajectories. Furthermore, to enhance driving safety and reduce collisions, we introduce a Diffusion Group Relative Policy Optimization (DiffGRPO) stage, reinforcing the planner for enhanced safety and comfort. Extensive experiments on the NAVSIM and Bench2Drive benchmarks demonstrate that ReCogDrive achieves state-of-the-art performance. Additionally, qualitative results across diverse driving scenarios and DriveBench highlight the model's scene comprehension.

Applications · Robotics

Zhao Jin, Zhengping Che, Tao Li, Zhen Zhao, Kun Wu, Yuheng Zhang, Yinuo Zhao, Zehui Liu, Qiang Zhang, Xiaozhu Ju 等

Robot learning increasingly relies on simulation to advance complex abilities such as dexterous manipulation and precise interaction, necessitating high-quality digital assets to bridge the sim-to-real gap. However, existing open-source articulated-object datasets for simulation are limited by insufficient visual realism and low physical fidelity, which hinders their utility for training models to master robotic tasks in the real world. To address these challenges, we introduce ArtVIP, a comprehensive open-source dataset comprising high-quality digital-twin articulated objects, accompanied by indoor-scene assets. Crafted by professional 3D modelers adhering to unified standards, ArtVIP ensures visual realism through precise geometric meshes and high-resolution textures, while physical fidelity is achieved via fine-tuned dynamic parameters. Meanwhile, the dataset pioneers embedded modular interaction behaviors within assets and pixel-level affordance annotations. Feature-map visualization and optical motion capture are employed to quantitatively demonstrate ArtVIP’s visual and physical fidelity, and its applicability is validated through imitation learning and reinforcement learning experiments. Provided in USD format with detailed production guidelines, ArtVIP is fully open-source, benefiting the research community and advancing robot learning research.

Applications · Robotics

Minghuan Liu, Zhengbang Zhu, Xiaoshen Han, PengHu, Haotong Lin, Xinyao Li, Jingxiao Chen, Jiafeng Xu, Yichu Yang, Yunfeng Lin 等

Modern robotic manipulation primarily relies on visual observations in a 2D color space for skill learning but suffers from poor generalization. In contrast, humans, living in a 3D world, depend more on physical properties-such as distance, size, and shape-than on texture when interacting with objects. Since such 3D geometric information can be acquired from widely available depth cameras, it appears feasible to endow robots with similar perceptual capabilities. Our pilot study found that using depth cameras for manipulation is challenging, primarily due to their limited accuracy and susceptibility to various types of noise. In this work, we propose Camera Depth Models (CDMs) as a simple plugin on daily-use depth cameras, which take RGB images and raw depth signals as input and output denoised, accurate metric depth. To achieve this, we develop a neural data engine that generates high-quality paired data from simulation by modeling a depth camera's noise pattern. Our results show that CDMs achieve nearly simulation-level accuracy in depth prediction, effectively bridging the sim-to-real gap for manipulation tasks. Notably, our experiments demonstrate, for the first time, that a policy trained on raw simulated depth, without the need for adding noise or real-world fine-tuning, generalizes seamlessly to real-world robots on two challenging long-horizon tasks involving articulated, reflective, and slender objects, with little to no performance degradation. We hope our findings will inspire future research in utilizing simulation data and 3D information in general robot policies. We release the dataset, models for various depth cameras, along with an easy-to-use guide for sim-to-real transfer at https://manipulation-as-in-simulation.github.io/.

Applications · Physics

Wenshuo Wang, Fan Zhang

Zero-Shot Super-Resolution Spatiotemporal Forecasting requires a deep learning model to be trained on low-resolution data and deployed for inference on high-resolution. Existing studies consider **maintaining** similar error across different resolutions as indicative of successful multi-resolution generalization performance. However, deep learning models serving as alternatives to numerical solvers should **reduce** error as resolution increases. The fundamental limitation is, the upper bound of physical law frequencies that low-resolution data can represent is constrained by its Nyquist frequency, making it difficult for models to process signals containing unseen frequency components during high-resolution inference. *This results in errors being anchored at low resolution, incorrectly interpreted as successful generalization.* We define this fundamental phenomenon as a new problem distinct from existing issues: **Scale Anchoring**. Therefore, we propose architecture-agnostic Frequency Representation Learning. It alleviates Scale Anchoring through resolution-aligned frequency representations and spectral consistency training: on grids with higher Nyquist frequencies, the frequency response in high-frequency bands of FRL-enhanced variants is more stable. This allows errors to decrease with resolution and significantly outperform baselines within our task and resolution range, while incurring only modest computational overhead.

Applications · Chemistry and Drug Discovery

Xingyu Su, Xiner Li, Masatoshi Uehara, Sunwoo Kim, Yulai Zhao, Gabriele Scalia, Ehsan Hajiramezanali, Tommaso Biancalani, Degui Zhi, Shuiwang Ji

We address the problem of fine-tuning diffusion models for reward-guided generation in biomolecular design. While diffusion models have proven highly effective in modeling complex, high-dimensional data distributions, real-world applications often demand more than high-fidelity generation, requiring optimization with respect to potentially non-differentiable reward functions such as physics-based simulation or rewards based on scientific knowledge. Although RL methods have been explored to fine-tune diffusion models for such objectives, they often suffer from instability, low sample efficiency, and mode collapse due to their on-policy nature. In this work, we propose an iterative distillation-based fine-tuning framework that enables diffusion models to optimize for arbitrary reward functions. Our method casts the problem as policy distillation: it collects off-policy data during the roll-in phase, simulates reward-based soft-optimal policies during roll-out, and updates the model by minimizing the KL divergence between the simulated soft-optimal policy and the current model policy. Our off-policy formulation, combined with KL divergence minimization, enhances training stability and sample efficiency compared to existing RL-based methods. Empirical results demonstrate the effectiveness and superior reward optimization of our approach across diverse tasks in protein, small molecule, and regulatory DNA design.

Applications · Chemistry and Drug Discovery

Aditya Sengar, Jiying Zhang, Pierre Vandergheynst, PATRICK BARTH

Simulating the long-timescale dynamics of biomolecules is a central challenge in computational science. While enhanced sampling methods can accelerate these simulations, they rely on pre-defined collective variables that are often difficult to identify, restricting their ability to model complex switching mechanisms between metastable states. A recent generative model, LD-FPG, demonstrated that this problem could be bypassed by learning to sample the static equilibrium ensemble as all-atom deformations from a reference structure, establishing a powerful method for all-atom ensemble generation. However, while this approach successfully captures a system's probable conformations, it does not model the temporal evolution between them. We introduce the Graph Latent Dynamics Propagator (GLDP), a modular component for simulating dynamics within the learned latent space of LD-FPG. We then compare three classes of propagators: (i) score-guided Langevin dynamics, (ii) Koopman-based linear operators, and (iii) autoregressive neural networks. Within a unified encoder–propagator–decoder framework, we evaluate long-horizon stability, backbone and side-chain ensemble fidelity, and temporal kinetics via TICA. Benchmarks on systems ranging from small peptides to mixed-topology proteins and large GPCRs reveal that autoregressive neural networks deliver the most robust long rollouts and coherent physical timescales; score-guided Langevin best recovers side-chain thermodynamics when the score is well learned; and Koopman provides an interpretable, lightweight baseline that tends to damp fluctuations. These results clarify the trade-offs among propagators and offer practical guidance for latent-space simulators of all-atom protein dynamics.

Ang Li, Charles L. Wang, Deqing Fu, Kaiyu Yue, Zikui Cai, Wang Zhu, Ollie Liu, Peng Guo, Willie Neiswanger, Furong Huang 等

Humans often rely on visual aids, such as diagrams or sketches, when tackling complex problems. Teaching multimodal models to adopt similar strategies, a process known as Visual Chain of Thought (visual CoT), is much more difficult. The main challenges are: (1) weak performance of off-the-shelf visual CoT, which hinders reinforcement learning, and (2) the lack of high-quality visual CoT training data. We introduce **Zebra-CoT** a diverse large-scale interleaved text-image reasoning dataset with 182,384 reasoning traces across 18 domains with over 50 distinct tasks. This dataset is specifically designed to train models to natively perform visual CoT. We emphasize four categories of tasks where sketching or visual reasoning is especially natural, spanning (a) *scientific questions* such as geometry, physics, and algorithms; (b) *2D visual reasoning tasks* like visual search and jigsaw puzzles; (c) *3D reasoning tasks* including 3D multi-hop inference, embodied and robot planning; and (d) *visual logic problems and strategic games* like chess. Fine-tuning Anole‑7B model on Zebra-CoT yields a +12\% improvement in our test‑set accuracy and up to +13\% performance gains on standard VLM benchmarks. Similarly, fine-tuning Bagel‑7B produces models capable of generating high-quality interleaved visual reasoning chains, underscoring Zebra-CoT's effectiveness in advancing multimodal reasoning.