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Applications · Language, Speech and Dialog

Lu Ma, Hao Liang, Meiyi Qiang, Lexiang Tang, Xiaochen Ma, Zhen Wong, Junbo Niu, Chengyu Shen, Runming He, Yanhao Li 等

Recent advances in large language model (LLM) reasoning have shown that reasoning ability can emerge through reinforcement learning (RL). However, despite these successes, RL in its current form remains insufficient to induce capabilities that exceed the limitations of the base model, as it is primarily optimized based on existing knowledge of the model. To address this limitation, we employ supervised fine-tuning (SFT) to learn what RL cannot, which enables the incorporation of new knowledge and reasoning patterns by leveraging high-quality demonstration data. We analyze the training dynamics of RL and SFT for LLM reasoning and find that RL excels at improving performance on questions within the model's original capabilities, while SFT is more effective at enabling progress on questions beyond the current scope of the model. Motivated by the complementary strengths of RL and SFT, we introduce \textbf{ReLIFT} (\textbf{Re}inforcement \textbf{L}earning \textbf{I}nterleaved with Online \textbf{F}ine-\textbf{T}uning), a novel training strategy. ReLIFT employs RL for general training, but interleaves it with targeted SFT on challenging questions for which high-quality solutions are collected online. By alternating between RL and SFT, ReLIFT addresses model weaknesses as they emerge. Empirically, ReLIFT outperforms previous RLVR methods by an average of +6.7 points across a suite of six benchmarks (five math reasoning and one out-of-distribution). More importantly, ReLIFT surpasses baselines such as individual RL, individual SFT, and various hybrid approaches while reducing the required training time. These results provide compelling evidence that ReLIFT is a powerful and resource-efficient paradigm for developing capable reasoning models. The code is available at \href{https://github.com/TheRoadQaQ/ReLIFT}{here}.

Applications · Neuroscience, Cognitive Science

Lorenzo Tausani, Paolo Muratore, Morgan B Talbot, Giacomo Amerio, Gabriel Kreiman, Davide Zoccolan

Uncovering which feature combinations are encoded by visual units is critical to understanding how images are transformed into representations that support recognition. While existing feature visualization approaches typically infer a unit's most exciting images, this is insufficient to reveal the manifold of transformations under which responses remain invariant, which is critical to generalization in vision. Here we introduce Stretch-and-Squeeze (SnS), an unbiased, model-agnostic, and gradient-free framework to systematically characterize a unit’s maximally invariant stimuli, and its vulnerability to adversarial perturbations, in both biological and artificial visual systems. SnS frames these transformations as bi-objective optimization problems. To probe invariance, SnS seeks image perturbations that maximally alter (stretch) the representation of a reference stimulus in a given processing stage while preserving unit activation downstream (squeeze). To probe adversarial sensitivity, stretching and squeezing are reversed to maximally perturb unit activation while minimizing changes to the upstream representation. Applied to CNNs, SnS revealed invariant transformations that were farther from a reference image in pixel-space than those produced by affine transformations, while more strongly preserving the target unit's response. The discovered invariant images differed depending on the stage of the image representation used for optimization: pixel-level changes primarily affected luminance and contrast, while stretching mid- and late-layer representations mainly altered texture and pose. By measuring how well the hierarchical invariant images obtained for $L_2$-robust (i.e., adversarially trained) networks were classified by humans and other observer networks, we discovered a substantial drop in their interpretability when the representation was stretched in deep layers, while the opposite trend was found for standard (i.e., not robustified) models. This indicates that $L_2$ adversarial training fails to increase the interpretability of high-level invariances, despite good perceptual alignment between humans and robustified models at the pixel level. This demonstrates how SnS can be used as a powerful new tool to measure the alignment between artificial and biological vision.

Chaitanya Kapoor, Alex Williams, Meenakshi Khosla

Representational similarity metrics typically force all units to be matched, making them susceptible to noise and outliers common in neural representations. We extend the soft-matching distance to a partial optimal transport setting that allows some neurons to remain unmatched, yielding rotation-sensitive but robust correspondences. This partial soft-matching distance provides theoretical advantages---relaxing strict mass conservation while maintaining interpretable transport costs---and practical benefits through efficient neuron ranking in terms of cross-network alignment without costly iterative recomputation. In simulations, it preserves correct matches under outliers and reliably selects the correct model in noise-corrupted identification tasks. On fMRI data, it automatically excludes low-reliability voxels and produces voxel rankings by alignment quality that closely match computationally expensive brute-force approaches. It achieves higher alignment precision across homologous brain areas than standard soft-matching, which is forced to match all units regardless of quality. In deep networks, highly matched units exhibit similar maximally exciting images, while unmatched units show divergent patterns. This ability to partition by match quality enables focused analyses, \emph{e.g.,} testing whether networks have privileged axes even within their most aligned subpopulations. Overall, partial soft-matching provides a principled and practical method for representational comparison under partial correspondence.

Deep Learning · Everything Else

Sanghyun Lee, Hoh In

Aligning Large Language Models with human preferences typically requires computationally intensive training or complex reward architectures. We introduce PALC (Preference Alignment via Logit Calibration), a parameter-efficient framework that achieves test-time alignment through a novel intervention strategy: direct calibration in vocabulary space. Unlike existing methods that manipulate entangled hidden representations or rely on external reward models, PALC operates at the logit layer where each dimension corresponds to a distinct token, providing interpretable and efficient control. Our approach employs a bottleneck architecture that learns to compress the base model's hidden states and generate position-dependent calibration vectors, requiring only a fraction of the base model's parameters. Through this design, PALC sidesteps the superposition problem inherent in representation engineering while eliminating the computational overhead of guided decoding methods. A single scaling factor enables runtime adjustment of alignment strength without retraining, allowing practitioners to balance between preserving model capabilities and enforcing preferences. Experiments demonstrate that PALC outperforms most test-time alignment methods while maintaining near-baseline inference speed. Our ablations reveal that human preferences concentrate on surprisingly low-dimensional manifolds, validating our architectural choices. By establishing vocabulary-space intervention as an effective alignment paradigm, PALC makes preference alignment accessible for resource-constrained deployments where traditional methods are infeasible, opening new avenues for scalable and adaptive AI alignment.

General Machine Learning · Transfer, Multitask and Meta-learning

Dongkyu Cho, Taesup Moon, Rumi Chunara, Kyunghyun Cho, Sungmin Cha

Continual learning (CL) has traditionally focused on minimizing exemplar memory, a constraint often misaligned with modern systems where GPU time, not storage, is the primary bottleneck. This paper challenges this paradigm by investigating a more realistic regime: one where memory is abundant enough to mitigate forgetting, but full retraining from scratch remains prohibitively expensive. In this practical "middle ground", we find that the core challenge shifts from stability to plasticity, as models become biased toward prior tasks and struggle to learn new ones. Conversely, improved stability allows simple replay baselines to outperform the state-of-the-art methods at a fraction of the GPU cost. To address this newly surfaced trade-off, we propose Weight Space Consolidation, a lightweight method that combines (1) rank-based parameter resets to restore plasticity with (2) weight averaging to enhance stability. Validated on both class-incremental learning with image classifiers and continual instruction tuning with large language models, our approach outperforms strong baselines while matching the low computational cost of replay, offering a scalable alternative to expensive full-retraining. These findings challenge long-standing CL assumptions and establish a new, cost-efficient baseline for real-world CL systems where exemplar memory is no longer the limiting factor.

Theory · Learning Theory

Lekai Chen, Ashutosh Trivedi, Alvaro Velasquez

Large Language Models (LLMs) are increasingly deployed in human–AI collaborative decision-making systems, where they are expected to align precise formal representations with ambiguous natural language. However, their ad hoc strategies for resolving ambiguity often lead to hallucinations and inconsistencies. We formalize this setting via probabilistic Minimally Adequate Teachers (pMATs) that (i) answer membership queries with fixed but possibly flipped labels, and (ii) return valid counterexamples to hypothesis equivalence. We present **CAPAL** (**C**lass-query **A**ctive, **P**ersistent-noise-**A**ware **L**earning), an active algorithm for learning deterministic finite automata (DFAs) that remains correct under persistent membership noise without demonstrations. CAPAL augments the classic \$L^\star\$ loop with two components grounded in our implementation: (1) a *class query* realized as a statistical same-state test that compares disagreements between two prefixes against a noise-floor estimate \$\hat{\eta}\$ with Hoeffding tolerances; (2) a *discrimination tree* that selects a near-minimal discriminator, keeping the core suffix set small. An efficient micro-bootstrap and cache-reuse scheme estimates \$\hat{\eta}\$ with few new queries. We prove convergence given a perfect language-equivalence oracle and show substantial membership-query savings in practice. Our evaluation across multiple benchmarks, including RegexLib and KB13, demonstrates that this approach enhances both the efficiency and robustness of DFA learning under noisy oracles, supporting the view of LLMs as fallible yet useful collaborators for synthesizing verifiable formal artifacts.

Applications · Physics

Bogdan Raonic, Siddhartha Mishra, Samuel Lanthaler

Data-driven models are increasingly adopted in critical scientific fields like weather forecasting and fluid dynamics. These methods can fail on out-of-distribution (OOD) data, but detecting such failures in regression tasks is an open challenge. We propose a new OOD detection method based on estimating joint likelihoods using a score-based diffusion model. This approach considers not just the input but also the regression model's prediction, providing a task-aware reliability score. Across numerous scientific datasets, including PDE datasets, satellite imagery and brain tumor segmentation, we show that this likelihood strongly correlates with prediction error. Our work provides a foundational step towards building a verifiable 'certificate of trust', thereby offering a practical tool for assessing the trustworthiness of AI-based scientific predictions.

Social Aspects · Accountability, Transparency and Interpretability

Fabian Fumagalli, R. Teal Witter, Christopher Musco

Shapley values have emerged as a central game-theoretic tool in explainable AI (XAI). However, computing Shapley values exactly requires $2^d$ game evaluations for a model with $d$ features. Lundberg and Lee's KernelSHAP algorithm has emerged as a leading method for avoiding this exponential cost. KernelSHAP approximates Shapley values by approximating the game as a linear function, which is fit using a small number of game evaluations for random feature subsets. In this work, we extend KernelSHAP by approximating the game via higher degree polynomials, which capture non-linear interactions between features. Our resulting PolySHAP method yields empirically better Shapley value estimates for various benchmark datasets, and we prove that these estimates are consistent. Moreover, we connect our approach to paired sampling (antithetic sampling), a ubiquitous modification to KernelSHAP that improves empirical accuracy. We prove that paired sampling outputs exactly the same Shapley value approximations as second-order PolySHAP, without ever fitting a degree 2 polynomial. To the best of our knowledge, this finding provides the first strong theoretical justification for the excellent practical performance of the paired sampling heuristic.

Applications · Climate

Bernardo Perrone Ribeiro, Jana Faganeli Pucer

Radar-based precipitation nowcasting, the task of forecasting short-term precipitation fields from previous radar images, is a critical problem for flood risk management and decision-making. While deep learning has substantially advanced this field, two challenges remain fundamental: the uncertainty of atmospheric dynamics and the efficient modeling of high-dimensional data. Diffusion models have shown strong promise by producing sharp, reliable forecasts, but their iterative sampling process is computationally prohibitive for time-critical applications. We introduce FlowCast, the first end-to-end probabilistic model leveraging Conditional Flow Matching (CFM) as a direct noise-to-data generative framework for precipitation nowcasting. Unlike hybrid approaches, FlowCast learns a direct noise-to-data mapping in a compressed latent space, enabling rapid, high-fidelity sample generation. Our experiments demonstrate that FlowCast establishes a new state-of-the-art in probabilistic performance while also exceeding deterministic baselines in predictive accuracy. A direct comparison further reveals the CFM objective is both more accurate and significantly more efficient than a diffusion objective on the same architecture, maintaining high performance with significantly fewer sampling steps. This work positions CFM as a powerful and practical alternative for high-dimensional spatiotemporal forecasting.

Computer Vision · Vision Models & Multimodal

Xiaobo Xing, Wei Yuan, Tong Chen, Quoc Viet Hung Nguyen, Xiangliang Zhang, Hongzhi Yin

Modeling semantic and structural information from tabular data remains a core challenge for effective table understanding. Existing Table-as-Text approaches flatten tables for large language models (LLMs), but lose crucial structural cues, while Table-as-Image methods preserve structure yet struggle with precise semantics. Recent Table-as-Multimodality strategies attempt to combine textual and visual views, but they (1) statically process both modalities for every query-table pair within large multimodal LLMs (MLLMs), inevitably introducing redundancy and even conflicts, and (2) depend on costly fine-tuning of MLLMs. In light of this, we propose TableDART, a training-efficient framework that integrates multimodal views by reusing pretrained single-modality models. TableDART introduces a lightweight 2.59M-parameter MLP gating network that dynamically selects the optimal path (Text-only, Image-only, or Fusion) for each table–query pair, reducing redundancy and avoiding conflicts that arise when textual and visual views of the same table provide inconsistent cues. By routing to the most appropriate view, our framework improves both accuracy and efficiency. In addition, we propose a novel agent to mediate cross-modal knowledge integration by analyzing outputs from text- and image-based models, either selecting the best result or synthesizing a new answer through reasoning. This design avoids the prohibitive costs of full MLLM fine-tuning. Extensive experiments on seven benchmarks show that TableDART establishes new state-of-the-art performance among open-source models, surpassing the strongest baseline by an average of 4.02%. The code is available at: https://github.com/xiaobo-xing/TableDART.

Deep Learning · Generative Models and Autoencoders

Bowei He, Yankai Chen, Xiaokun Zhang, Linghe Kong, Philip Yu, Xue Liu, Chen Ma

Knowledge distillation from Large Language Models (LLMs) to smaller models has emerged as a critical technique for deploying efficient AI systems. However, current methods for distillation via synthetic data lack pedagogical awareness, treating knowledge transfer as a one-off data synthesis and training task rather than a systematic learning process. In this paper, we propose a novel pedagogically-inspired framework for LLM knowledge distillation that draws from fundamental educational principles. Our approach introduces a three-stage pipeline—**Knowledge Identifier**, **Organizer**, and **Adapter** (**IOA**)—that systematically identifies knowledge deficiencies in student models, organizes knowledge delivery through progressive curricula, and adapts representations to match the cognitive capacity of student models. We integrate Bloom's Mastery Learning Principles and Vygotsky's Zone of Proximal Development to create a dynamic distillation process where student models approach teacher model's performance on prerequisite knowledge before advancing, and new knowledge is introduced with controlled, gradual difficulty increments. Extensive experiments using LLaMA-3.1/3.2 and Qwen2.5 as student models demonstrate that IOA achieves significant improvements over baseline distillation methods, with student models retaining 94.7\% of teacher performance on DollyEval while using less than 1/10th of the parameters. Our framework particularly excels in complex reasoning tasks, showing 19.2\% improvement on MATH and 22.3\% on HumanEval compared with state-of-the-art baselines.

Social Aspects · Trustworthy Machine Learning

Xudong Zhu, Mohammad Mahdi Khalili, Zhihui Zhu

Sparse autoencoders (SAEs) have emerged as powerful techniques for interpretability of large language models (LLMs), aiming to decompose hidden states into meaningful semantic features. While several SAE variants have been proposed, there remains no principled framework to derive SAEs from the original dictionary learning formulation. In this work, we introduce such a framework by unrolling the proximal gradient method for sparse coding. We show that a single-step update naturally recovers common SAE variants, including ReLU, JumpReLU, and TopK. Through this lens, we reveal a fundamental limitation of existing SAEs: their sparsity-inducing regularizers enforce non-negativity, preventing a single feature from representing bidirectional concepts (e.g., male vs. female). This structural constraint fragments semantic axes into separate, redundant features, limiting representational completeness. To address this issue, we propose AbsTopK SAE, a new variant derived from the $\ell_0$ sparsity constraint that applies hard thresholding over the largest-magnitude activations. By preserving both positive and negative activations, AbsTopK uncovers richer, bidirectional conceptual representations. Comprehensive experiments across multiple LLMs and seven probing and steering tasks show that AbsTopK improves reconstruction fidelity, enhances interpretability, and enables single features to encode contrasting concepts. Remarkably, AbsTopK matches or even surpasses the Difference-in-Mean method—a supervised approach that requires labeled data for each concept and has been shown in prior work to outperform SAEs.

Deep Learning · Graph Neural Networks

Louis Emiel T Van Langendonck, Guillermo Bernardez, Nina Miolane, Pere Barlet-Ros

A fundamental challenge in graph learning is understanding how models generalize to new, unseen graphs. While synthetic benchmarks offer controlled settings for analysis, existing approaches are confined to single-graph, transductive settings where models train and test on the same graph structure. Addressing this gap, we introduce GraphUniverse, a framework for generating entire families of graphs to enable the first systematic evaluation of inductive generalization at scale. Our core innovation is the generation of graphs with persistent semantic communities, ensuring conceptual consistency while allowing fine-grained control over structural properties like homophily and degree distributions. This enables crucial but underexplored robustness tests, such as performance under controlled distribution shifts. Benchmarking a wide range of architectures—from GNNs to graph transformers and topological architectures—reveals that strong transductive performance is a poor predictor of inductive generalization. Furthermore, we find that robustness to distribution shift is highly sensitive not only to model architecture choice but also to the initial graph regime (e.g., high vs. low homophily). Beyond benchmarking, GraphUniverse’s flexibility and scalability can facilitate the development of robust and truly generalizable architectures. An interactive demo is available at https://graphuniverse.streamlit.app.

Applications · Robotics

Yuqi Wang, Xinghang Li, Wenxuan Wang, Junbo Zhang, Yingyan Li, Yuntao Chen, Xinlong Wang, Zhaoxiang Zhang

Vision-language-action models (VLAs) have garnered significant attention for their potential in advancing robotic manipulation. However, previous approaches predominantly rely on the general comprehension capabilities of vision-language models (VLMs) to generate action signals, often overlooking the rich temporal and causal structure embedded in visual observations. In this paper, we present UniVLA, a unified and native multimodal VLA model that autoregressively models vision, language, and action signals as discrete token sequences. This tokenized formulation naturally supports flexible multimodal task learning, particularly from large-scale video data, and further demonstrates that generative vision supervision can significantly enhance visual understanding. By incorporating world modeling during post-training, UniVLA captures causal dynamics from videos, facilitating effective transfer to downstream policy learning—especially for long-horizon tasks. Our approach sets new state-of-the-art results across several widely used simulation benchmarks, including CALVIN, LIBERO, and Simplenv-Bridge, substantially outperforming prior methods. For example, UniVLA achieves 95.5% average success rate on LIBERO benchmark, surpassing π₀-FAST's 85.5%. We further demonstrate its broad applicability through experiments on real-world ALOHA manipulation tasks and autonomous driving scenarios.

Computer Vision · Classification and Understanding

siheng wang, Yanshu Li, Bohan Hu, Zhengdao Li, HaiboZhan, Linshan Li, Weiming Liu, Ruizhi Qian, Guangxin Wu, Hao Zhang 等

Open-Vocabulary Object Detection (OVOD) plays a critical role in autonomous driving and human-computer interaction by enabling perception beyond closed-set categories. However, current approaches predominantly rely on multimodal fusion, facing dual limitations: multimodal fusion methods incur heavy computational overhead from text encoders, while task-coupled designs compromise between detection precision and open-world generalization. To address these challenges, we propose Decoupled Cognition DETR, a vision framework featuring a three-stage cognitive distillation mechanism: Dynamic Hierarchical Concept Pool constructs self-evolving concept prototypes using LLaVA-generated region descriptions filtered by CLIP alignment, aiming to replace costly text encoders and reduce computational overhead; Hierarchical Knowledge Distillation decouples visual-semantic space mapping via prototype-centric projection, avoiding task coupling to enhance open-world generalization; Parametric Decoupling Training coordinates localization and cognition through dual-stream gradient isolation, further optimizing detection precision. Extensive experiments on the common OVOD evaluation protocol demonstrated that DeCo-DETR achieves state-of-the-art performance compared to existing OVOD methods. It provides a new paradigm for extending OVOD to more real-world applications.

Reinforcement Learning · Deep RL

Manuel Serra Nunes, Atabak Dehban, Yiannis Demiris, José Santos-Victor

Despite the significant advances in Deep Reinforcement Learning (RL) observed in the last decade, the amount of training experience necessary to learn effective policies remains one of the primary concerns in both simulated and real environments. Looking to solve this issue, previous work has shown that improved efficiency can be achieved by separately modeling the agent and environment, but usually requires a supervisory signal. In contrast to RL, humans can perfect a new skill from a small number of trials and often do so without a supervisory signal, making neuroscientific studies of human development a valuable source of inspiration for RL. In particular, we explore the idea of motor prediction, which states that humans develop an internal model of themselves and of the consequences that their motor commands have on the immediate sensory inputs. Our insight is that the movement of the agent provides a cue that allows the duality between the agent and environment to be learned. To instantiate this idea, we present Ego-Foresight (EF), a self-supervised method for disentangling agent information based on motion and prediction. Our main finding is that, when used as an auxiliary task in feature learning, self-supervised agent-awareness improves the sample-efficiency and performance of the underlying RL algorithm. To test our approach, we study the ability of EF to predict agent movement and disentangle agent information. Then, we integrate EF with both model-free and model-based RL algorithms to solve simulated control tasks, showing improved sample-efficiency and performance.

Computer Vision · Vision Models & Multimodal

Bingjun Luo, Tony Wang, Chaoqi Chen, Xinpeng Ding

Multimodal Large Language Models (MLLMs) face significant computational overhead when processing long videos due to the massive number of visual tokens required. To improve efficiency, existing methods primarily reduce redundancy by pruning or merging tokens based on importance or similarity. However, these approaches largely overlook a critical dimension of video content, i.e., changes and turning points, and they lack a collaborative model for spatio-temporal relationships. To address this, we propose a new perspective: similarity is for identifying redundancy, while difference is for capturing key events. Based on this, we designed a training-free framework named ST-SimDiff. We first construct a spatio-temporal graph from the visual tokens to uniformly model their complex associations. Subsequently, we employ a parallel dual-selection strategy: 1) similarity-based selection uses community detection to retain representative tokens, compressing static information; 2) temporal difference-based selection precisely locates content-changing points to preserve tokens that capture key dynamic shifts. This allows it to preserve both static and dynamic content with a minimal number of tokens. Extensive experiments show our method significantly outperforms state-of-the-art approaches while substantially reducing computational costs. Our code is available in [https://github.com/bingjunluo/ST-SimDiff](https://github.com/bingjunluo/ST-SimDiff).

Zheng Huang, Enpei Zhang, Weikang Qiu, Yinghao Cai, Carl Yang, Elynn Chen, Xiang Zhang, Rex Ying, Dawei Zhou, Yujun Yan

Understanding how the brain encodes visual information is a central challenge in neuroscience and machine learning. A promising approach is to reconstruct visual stimuli—essentially images—from functional Magnetic Resonance Imaging (fMRI) signals. This involves two stages: transforming fMRI signals into a latent space and then using a pre-trained generative model to reconstruct images. The reconstruction quality depends on how similar the latent space is to the structure of neural activity and how well the generative model produces images from that space. Yet, it remains unclear which type of latent space best supports this transformation and how it should be organized to represent visual stimuli effectively. We present two key findings. First, fMRI signals are more similar to the text space of a language model than to either a vision-based space or a joint text–image space. Second, text representations and the generative model should be adapted to capture the compositional nature of visual stimuli, including objects, their detailed attributes, and relationships. Building on these insights, we propose PRISM, a model that Projects fMRI sIgnals into a Structured text space as an interMediate representation for visual stimuli reconstruction. It includes an object-centric diffusion module that generates images by composing individual objects to reduce object detection errors, and an attribute/relationship search module that automatically identifies key attributes and relationships that best align with the neural activity. Extensive experiments on real-world datasets demonstrate that our framework outperforms existing methods, achieving up to an 6% reduction in perceptual loss. These results highlight the importance of using structured text as an intermediate space to bridge fMRI signals and image reconstruction. Codes are available at https://github.com/GraphmindDartmouth/PRISM.

Applications · Robotics

Shilpa Mukhopadhyay, Amit Roy-Chowdhury, Hang Qiu

Cooperative perception enables autonomous agents to share encoded representations over wireless communication to enhance each other’s live situational awareness. However, the tension between the limited communication bandwidth and the rich sensor information hinders its practical deployment. Recent studies have explored selection strategies that share only a subset of features per frame while striving to keep the performance on par. Nevertheless, the bandwidth requirement still stresses current wireless technologies. To fundamentally ease the tension, we take a proactive approach, exploiting the temporal continuity to identify features that capture environment dynamics, while avoiding repetitive and redundant transmission of static information. By incorporating temporal awareness, agents are empowered to dynamically adapt the sharing quantity according to environment complexity. We instantiate this intuition into an adaptive selection framework, COOPERTRIM, which introduces a novel conformal temporal uncertainty metric to gauge feature relevance, and a data-driven mechanism to dynamically determine the sharing quantity. To evaluate COOPERTRIM, we take semantic segmentation and 3D detection as example tasks. Across multiple open-source cooperative segmentation and detection models, COOPERTRIM achieves up to 80.28% and 72.52% bandwidth reduction respectively while maintaining a comparable accuracy. Relative to other selection strategies, COOPERTRIM also improves IoU by as much as 45.54% with up to 72% less bandwidth. Combined with compression strategies, COOPERTRIM can further reduce bandwidth usage to as low as 1.46% without compromising IoU performance. Qualitative results show COOPERTRIM gracefully adapts to environmental dynamics, localization error, and communication latency, demonstrating flexibility and paving the way for real-world deployment.

Applications · Genetics, Cell Biology, Health, etc

Yihang Xiao, Jinyi Liu, YAN ZHENG, Shaoqing Jiao, Jianye Hao, Xiaohan Xie, Limingzhi, Ruitao Wang, Fei Ni, Yuxiao Li 等

Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) data analysis are pivotal for advancing biological research, enabling precise characterization of cellular heterogeneity. However, existing analysis approaches require extensive manual programming and complex tool integration, posing significant challenges for researchers. To address this, we introduce CellAgent, an autonomous, LLM-driven approach that performs end-to-end scRNA-seq and spatial transcriptomics data analysis through natural language interactions. CellAgent employs a multi-agent hierarchical decision-making framework, simulating a “deep-thinking” workflow to ensure that analytical steps are logically coherent and aligned with the overarching research goal. To further enhance its capabilities, we develop sc-Omni, a high-performance, expert-curated toolkit that consolidates essential tools for scRNA-seq and spatial transcriptomics analysis. Additionally, we introduce a self-reflective optimization mechanism, enabling automated, iterative refinement of results through specialized evaluation methods, effectively replacing traditional manual assessments. Benchmarking against human experts demonstrates that CellAgent achieves significant improvement in efficiency across multiple downstream applications while maintaining excellent performance comparable to existing approaches and preserving natural language interactions. By translating high-level scientific questions into optimized computational workflows, CellAgent represents a step toward a new, more accessible paradigm in bioinformatics, allowing researchers to perform complex data analyses autonomously. In lowering technical barriers, CellAgent serves to advance the democratization of the scientific discovery process in genomics.